Explanipedia

VEGF mRNA Expression in Epithelial Ovarian Cancer: Correlation with rs699947 Gene Variant Open

Yuda Nabella Prameswari, Dwi Anita Suryandari, Dewi Sukmawati, Luluk Yunaini, Ria Kodariah · 2025

Background: Angiogenesis is the formation of new blood vessels, is crucial for cancer growth and metastasis, including in epithelial ovarian cancer (EOC). Vascular Endothelial Growth Factor (VEGF) regulates angiogenesis, and its elevated m…

Immunohistochemistry Assessment of Hepatocyte Growth Factor (HGF)/Mesenchymal-Epithelial Transition Factor Receptor (C-MET) as a Biomarker for Malignancy Grading in Ovarian Cancer Open

Ria Kodariah, Tantri Hellyanti, Angeline Maranata, Yayi Dwina Billianti · 2025

This study investigated the expression of hepatocyte growth factor (HGF), its receptor c-MET, and the proliferation marker Ki-67 across different histological grades of ovarian carcinoma. Archived formalin-fixed, paraffin-embedded (FFPE) t…

T HELPER 17 (Th17) AND REGULATORY T (Treg) CELLS PROFILE IN TYPE-2 DIABETES MELLITUS (T2DM) Open

Indranita Dwikarjanti, Desak Gede Budi Krisnamurti, Ria Kodariah · 2025

One of metabolic disorder disease is Type 2 Diabetes mellitus (DM), leading to increased glucose, cholesterol, and lipid levels in the blood. Type 2 DM results in insulin resistance within the body. Glycolysis, oxidative phosphorylation, a…

Oxidative Stress, DNA Fragmentation and Caspase-3 Regulation in HIV-1 Positive Men: A Study of Sperm Preparation Open

Margaretha Napitupulu, Friska Zai, Silvia Werdhy Lestari, Latisha Witjaksono, Zulfikar Drakel , et al. · 2025

The impact of human immunodeficiency virus (HIV) infection on male fertility, specifically sperm quality, remains inconclusive in global studies. However, stable HIV-positive men undergoing antiretroviral therapy (ARV) experience improved …

Identification of AKNA Gene and Its Role for Genetic Susceptibility in Epithelial Ovarian Cancer Open

Dwi Anita Suryandari, Miftahuzzakiyah Miftahuzzakiyah, Luluk Yunaini, Ria Kodariah, Dewi Sukmawati , et al. · 2025

AKNA is identified as a gene that regulates inflammation, immune response, and Epithelial–Mesenchymal Transition (EMT), which plays an important role in the progression of epithelial ovarian cancer. In this study, we analyzed the genotype …

Potential of AKNA as a Predictive Biomarker for Ovarian Cancer and Its Relationship to Tumor Grading Open

Primariadewi Rustamadji, Elvan Wiyarta, M Miftahuzzakiyah, Dewi Sukmawati, DA Suryandari , et al. · 2024

Background: Ovarian cancer exhibits a significant prevalence and incidence on a global scale. Low-grade or high-grade epithelial-type ovarian cancer can be classified by using the dualistic model. Inflammation has been associated with AKNA…

Analysis of H3k27me3 Expression in Malignant Peripheral Nerve Sheath Tumor (MPNST) and Other Spindle Cell Sarcoma Mimicking MPNST Open

William Yordana, Evelina Evelina, Ria Kodariah · 2023

Malignant Peripheral Nerve Sheath Tumor (MPNST) is a type of spindle cell sarcoma with approximately 5% of all sarcomas. Its diagnosis is challenging due to the absence of specific immunohistochemical markers. Recently, H3K27me3 was discov…

HGF/C-Met Expression in Epithelial Ovarian Carcinogenesis and Its Potential as Molecular Targeted Therapy Open

Angeline Maranata, Tantri Hellyanti, Ria Kodariah · 2023

Background: The Mesenchymal-Epithelial Transition factor (C-Met) is a tyrosine kinase receptor (TKR) that binds to a ligand called Hepatocyte Growth Factor (HGF). Recent studies conducted on patients with epithelial ovarian cancer (EOC) re…

The Effect of Lunasin on Inhibition of KI67, BCL-2 and C-MYC Expression in Azoxymethane and Dextran Sodium Sulfate Induced Mice Colon Open

Kusmardi Kusmardi, Ahmat Rediansya Putra Ahmat Rediansya Putra, Ria Kodariah · 2023

Treatment of cancer using medicinal-plant based has been important due to minimal side effects, high efficiency and low cost. Lunasin from soybean is known as potential chemopreventive agent. This study aimed to study and investigate the p…

Ekspresi VEGF di Jaringan Hati Tikus Pasca Induksi 2AAF/CCl4 Open

Isabella Kurnia Liem, Radietya Alvarabie, Fanny Oktorina, Firda Asma’ul Husna, Puspita Eka Wuyung , et al. · 2023

Vascular Endothelial Growth Factor (VEGF) merupakan sebuah faktor angiogenik poten yang terpicu ekspresinya jika jaringan hati mengalami cedera. Pada cedera hati kronis, VEGF diduga dapat berperan sebagai faktor pro-fibrotik atau anti-fibr…

Ekspresi VEGF di Jaringan Hati Tikus Pasca Induksi 2AAF/CCl4 Open

Isabella Kurnia Liem, Radietya Alvarabie, Fanny Oktorina, Firda Asma’ul Husna, Puspita Eka Wuyung , et al. · 2023

Vascular Endothelial Growth Factor (VEGF) merupakan sebuah faktor angiogenik poten yang terpicu ekspresinya jika jaringan hati mengalami cedera. Pada cedera hati kronis, VEGF diduga dapat berperan sebagai faktor pro-fibrotik atau anti-fibr…

RELA mRNA Expression in Epithelial Ovarian Cancer: Correlation with rs11820062 Gene Variant Open

Benedikta Diah Saraswati, Dwi Anita Suryandari, Ria Kodariah, Dewi Sukmawati, Luluk Yunaini , et al. · 2023

and its correlation to i mRNA expression in low-grade and high-grade EOC’s patients from Dr. Cipto Mangunkusumo General hospital, Indonesia. Methods: This study is cross-sectional with a total of 65 healthy subjects and 80 ovarian biopsies…

Association of Programmed Death-Ligand 1 Expression with Aggressive Histological Types of Thyroid Carcinoma Open

Harahap AS, Lay FK, Ria Kodariah, Wongkar FJ, Ham MF · 2022

Agnes Stephanie Harahap,1,2 Fanny Kamarudy Lay,1 Ria Kodariah,1 Fresia Juwitasari Wongkar,1 Maria Francisca Ham1,2 1Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Ind…

Association of Programmed Death-Ligand 1 Expression with Aggressive Histological Types of Thyroid Carcinoma Open

Agnes Stephanie Harahap, Fanny Kamarudy Lay, Ria Kodariah, Fresia Juwitasari Wongkar, Maria Francisca Ham · 2022

In conclusion, the present study found a significant association between PD-L1 expression and the aggressive histological type of TC. In addition, a potential association between PD-L1 expression and the presence of extrathyroidal extensio…

Raw fastq data for hotspot regions of cancer-related 50 genes using fresh frozen breast carcinoma tissues obtained from IMERI-FMUI biobank collections Open

Ria Kodariah, Fadilah Fadilah, Rafika Indah Paramita, Linda Erlina, Khaerunissa Anbar Istiadi , et al. · 2022

DATA REPORT article Front. Genet., 24 October 2022Sec. Computational Genomics Volume 13 - 2022 | https://doi.org/10.3389/fgene.2022.973453

CK19 and OV6 Expressions in the Liver of 2-AAF/CCl4 Rat Model Open

Romy Arwinda, Isabella Kurnia Liem, Ayu Eka Fatril, Fanny Oktorina, Firda Asma’ul Husna , et al. · 2022

BACKGROUND: Liver regeneration on a chronic liver injury with rat model research is urgent to study the pathology of human chronic diseases. 2-Acetylaminofluorene (2-AAF) and Carbon Tetrachloride (CCl4) can be applied to study about liver …

Human spermatogonia stem cells (SSCS) in a culture system with platelet rich plasma and correlations with spermatogenesis level Open

Silvia Werdhy Lestari, Debby Aditya, Firda Asma’ul Husna, Gita Pratama, Dwi Anita Suryandari , et al. · 2022

There are instances when the sperm fail to be obtained from the testes in assisted reproductive technology (ART) of azoospermia infertility due to spermatogenesis arrest. Therefore, spermatogonial stem cells (SSCs) may be used as an altern…

Comparison of Two Methods of 2AAF/CCL4 Exposure to Induce Rat Animal Model of Chronic Liver Injury Open

Isabella Kurnia Liem, Zakiyah Zakiyah, Reni Oktavina, Irwina Eka Deraya, Ria Kodariah , et al. · 2021

Since chronic liver injury has becoming a global public health problem, many research to elucidate the pathological and regeneration mechanism, that lead to the need of creating an animal model of chronic liver injury. The aim of the study…

Histopathology and ARID1A Expression in Endometriosis- Associated Ovarian Carcinoma (EAOC) Carcinogenesis Model with Endometrial Autoimplantation and DMBA Induction Open

Puspita Eka Wuyung, Familia Bella Rahadiati, Hartono Tjahjadi, Salinah Salinah, Kusmardi Kusmardi , et al. · 2021

The combination of endometrial autoimplantation techniques and DMBA induction in the ovary produced atypical endometriosis, clear cell carcinoma, and endometrioid carcinoma, where time is an important factor. There was no significant diffe…

Intravenous Injection of Umbilical Cord-Derived Mesenchymal Stem Cells Improved Regeneration of Rat Liver after 2AAF/CCl<sub>4</sub>-Induced Injury Open

Isabella Kurnia Liem, Reni Oktavina, Zakiyah, Dian Anggraini, Irwina Eka Deraya , et al. · 2021

The effectivity of Mesenchymal Stem Cell (MSC) therapy for chronic liver injury is still questioned due to its possibility to have a pro-fibrotic effects. Other consideration is the preferably peripheral Intravenous (IV) route of applicati…

Rapid nasopharyngeal brush-smear cytology with Epstein-Barr virus DNA load and viral marker analysis for detection of nasopharyngeal carcinoma Open

Octavia Ramayanti, Lisnawati Rachmadi, Ria Kodariah, Handayani SI, I Budiningsih , et al. · 2021

Background: Nasopharyngeal carcinoma (NPC) is a prevalent cancer in Indonesia, usually identified at late stage.Epstein-Barr virus (EBV) gene products are present in all tumor cells.Early-stage NPC diagnosis is clinically important but dif…

The Expression of Programmed Death Ligand-1 (Pd-L1) in Testicular Seminoma as Potential Prognostic Factor Open

Freciyana Boedijono, Budiana Tanurahardja, Ria Kodariah · 2020

BackgroundThe prognosis of testicular seminoma cases which failed to be cured with conventional therapy is poor. Several recurrent eventsafter chemotherapy were also found. PD-L1 is expressed in various types of malignancy and tumor infilt…

Clinical, Molecular, and Histopathological Aspect of Primary Biliary Cholangitis Open

Flora Dameria, Marini Stephanie, Ria Kodariah, Diah Rini Handjari, Ening Krisnuhoni , et al. · 2020

Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune liver disease which tends to be chronic and progressive in nature that is marked by the presence of cholangitis and small size biliary duct …

Role of CD44 in Non-Alcoholic Steatohepatitis (NASH) Progressivity Open

Sarwanti, Marini Stephanie, Ria Kodariah · 2020

Non alcoholic Steatohepatitis (NASH) is part of a group of conditions called Non-Alcoholic Fatty Liver Diseases(NAFLD) where it is a chronic disease, which defined after elimination other causes of fatty liver, such as excessivealcohol con…

Environmental Enrichment and Aerobic Exercise Enhances Spatial Memory and Synaptophysin Expression in Rats Open

Diah Ayu Aguspa Dita, Nurul Paramita, Ria Kodariah, Neng Tine Kartinah · 2020

BACKGROUND: Exposure to environmental enrichment has a positive effect on brain function, including improved cognition. Environmental enrichment has many aspects, including social interactions, object stimulations, and physical activities.…

Peranan Gen HOXA10 terhadap Infertilitas Terkait Endometriosis Open

Salinah Salinah, Ria Kodariah, Puspita Eka Wuyung · 2020

Endometriosis merupakan penyakit yang bersifat progresif, kronik, rekuren dan hingga saat ini etiologi pastinya belum diketahui. Gejala yang ditimbulkan endometriosis bervariasi mulai dari asimptomatik, nyeri pelvis hingga infertilitas. Be…

Aerobic exercise combined with environmental enrichment improves spatial memory and enhances neuroligin 1 expression: an animal study Open

Faizah Abdullah Djawas, Sri Redjeki, Ria Kodariah, Neng Tine Kartinah · 2019

BACKGROUND Numerous studies have revealed that aerobic exercise (AE) or environmental enrichment (EE) exert positive effects on the molecular, cellular, and structural changes responsible for functional plasticity. Therefore, this study wa…

The effect of dadih in BALB/c mice on pro-inflammatory and anti-inflammatory cytokine productions Open

Ria Kodariah, Hadits Lissentiya Armal, Heri Wibowo, Andi Yasmon · 2019

The normal microflora formed as commensal bacteria have roles in maintaining homeostasis in the intestine tract. The reduction in the amount and on the diversity of the commensal bacteria lead to gastrointestinal dysbiosis which increase n…

The Effect of Omega-3-enriched Fish oil on the Inflammation of Mice Colon Induced by AOM and DSS: Study on COX-2 Open

Kusmardi Kusmardi, Pater Dean Adare, Ria Kodariah · 2019

Introduction: Colorectal cancer is one of the leading causes of cancer deaths in some countries of the world. Inflammation has been recognized as one of the etiologies of colorectal cancer. Omega-3 is known to have anti-inflammatory proper…

The effect of dadih in BALB/c mice on pro-inflammatory and anti-inflammatory cytokine productions Open

Ria Kodariah, Hadits Lissentiya Armal, Heri Wibowo, Andi Yasmon · 2019

The normal microflora formed as commensal bacteria have roles in maintaining homeostasis in the intestine tract.The reduction in the amount and on the diversity of the commensal bacteria lead to gastrointestinal dysbiosis which increase nu…

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