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View article: Assessment of Preanalytical Cerebrospinal Fluid Handling and Storage Factors on Measurement of Aβ1-42, Aβ1-40, and pTau181 Using an Automated Chemiluminescent Platform
Assessment of Preanalytical Cerebrospinal Fluid Handling and Storage Factors on Measurement of Aβ1-42, Aβ1-40, and pTau181 Using an Automated Chemiluminescent Platform Open
Background Standardizing cerebrospinal fluid (CSF) laboratory protocols will improve the reliability and availability of clinical biomarker testing required for prescription of novel Alzheimer disease (AD) therapies. This study evaluated s…
View article: Strategic Variants of CSP Delivered as SynDNA Vaccines Demonstrate Heterogeneity of Immunogenicity and Protection from <i>Plasmodium</i> Infection in a Murine Model
Strategic Variants of CSP Delivered as SynDNA Vaccines Demonstrate Heterogeneity of Immunogenicity and Protection from <i>Plasmodium</i> Infection in a Murine Model Open
Malaria infects millions of people every year, and despite recent advances in controlling disease spread, such as vaccination, it remains a global health concern. The circumsporozoite protein (CSP) has long been acknowledged as a key targe…
View article: The Alzheimer's Association international guidelines for handling of cerebrospinal fluid for routine clinical measurements of amyloid β and tau
The Alzheimer's Association international guidelines for handling of cerebrospinal fluid for routine clinical measurements of amyloid β and tau Open
The core cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers amyloid beta (Aβ42 and Aβ40), total tau, and phosphorylated tau, have been extensively clinically validated, with very high diagnostic performance for AD, including the…
View article: Prediction of amyloid PET status using the LUMIPULSE <i>G</i> β‐amyloid ratio (1‐42/1‐40)
Prediction of amyloid PET status using the LUMIPULSE <i>G</i> β‐amyloid ratio (1‐42/1‐40) Open
Background Cerebrospinal fluid (CSF) amyloid biomarker concentrations are valuable in the assessment of patients for Alzheimer’s dementia (AD). Automated platforms and the additional measurement of Aβ1‐40(Aβ40) with Aβ1‐42(Aβ42) has decrea…
View article: Protection against <i>Borreliella burgdorferi</i> infection mediated by a synthetically engineered DNA vaccine
Protection against <i>Borreliella burgdorferi</i> infection mediated by a synthetically engineered DNA vaccine Open
Lyme disease is the most common vector-borne disease in North America. The etiological agent is the spirochete Borreliella burgdorferi, transmitted to mammalian hosts by the Ixodes tick. In recent years there has been an increase in the nu…
View article: Effect of Patient-Specific Preanalytic Variables on CSF Aβ1–42 Concentrations Measured on an Automated Chemiluminescent Platform
Effect of Patient-Specific Preanalytic Variables on CSF Aβ1–42 Concentrations Measured on an Automated Chemiluminescent Platform Open
Background Cerebrospinal fluid (CSF) biomarkers are increasingly used to confirm the accuracy of a clinical diagnosis of mild cognitive impairment or dementia due to Alzheimer disease (AD). Recent evidence suggests that fully automated ass…
View article: Pre-exposure Immunoprophylaxis by Genetically Encoded DMAb anti-OspA Human Monoclonal Antibody to Prevent Lyme Disease
Pre-exposure Immunoprophylaxis by Genetically Encoded DMAb anti-OspA Human Monoclonal Antibody to Prevent Lyme Disease Open
Tick transmission of Borrelia spirochetes to humans results in significant morbidity from Lyme disease. Animal studies have demonstrated that transmission of Borrelia from tick vector to the mammalian host can be blocked by antibodies agai…
View article: Concordance of Lumipulse cerebrospinal fluid t‐tau/Aβ42 ratio with amyloid PET status
Concordance of Lumipulse cerebrospinal fluid t‐tau/Aβ42 ratio with amyloid PET status Open
Introduction Cerebrospinal fluid (CSF) biomarkers can identify individuals with Alzheimer's disease (AD) pathology (eg, amyloid plaques, neurofibrillary tangles), but defined analyte cut‐points using high‐throughput automated assays are ne…
View article: P4‐476: EFFECT OF PATIENT‐SPECIFIC PRE‐ANALYTIC VARIABLES ON CSF Aβ42 CONCENTRATIONS MEASURED ON AN AUTOMATED CHEMILUMINESCENT PLATFORM
P4‐476: EFFECT OF PATIENT‐SPECIFIC PRE‐ANALYTIC VARIABLES ON CSF Aβ42 CONCENTRATIONS MEASURED ON AN AUTOMATED CHEMILUMINESCENT PLATFORM Open
Cerebrospinal fluid (CSF) biomarker concentrations are valuable in the diagnosis of Alzheimer's Disease (AD). CSF β-amyloid 1–42 (Aβ42), is a core biomarker of AD. While analytic variability has been reduced with the advent of automated as…
View article: In Vivo Delivery of a DNA-Encoded Monoclonal Antibody Protects Non-human Primates against Zika Virus
In Vivo Delivery of a DNA-Encoded Monoclonal Antibody Protects Non-human Primates against Zika Virus Open
Zika virus (ZIKV) infection is endemic to several world regions, and many others are at high risk for seasonal outbreaks. Synthetic DNA-encoded monoclonal antibody (DMAb) is an approach that enables in vivo delivery of highly potent mAbs t…
View article: Anti-OspA DNA-Encoded Monoclonal Antibody Prevents Transmission of Spirochetes in Tick Challenge Providing Sterilizing Immunity in Mice
Anti-OspA DNA-Encoded Monoclonal Antibody Prevents Transmission of Spirochetes in Tick Challenge Providing Sterilizing Immunity in Mice Open
We recently developed anti-OspA human immunoglobulin G1 monoclonal antibodies (HuMAbs) that are effective in preventing Borrelia transmission from ticks in a murine model. Here, we investigated a novel approach of DNA-mediated gene transfe…
View article: Rapid response to an emerging infectious disease – Lessons learned from development of a synthetic DNA vaccine targeting Zika virus
Rapid response to an emerging infectious disease – Lessons learned from development of a synthetic DNA vaccine targeting Zika virus Open
Vaccines are considered one of the greatest advances in modern medicine. The global burden of numerous infectious diseases has been significantly reduced, and in some cases, effectively eradicated through the deployment of specific vaccine…
View article: Screening of a Haloferax volcanii Transposon Library Reveals Novel Motility and Adhesion Mutants
Screening of a Haloferax volcanii Transposon Library Reveals Novel Motility and Adhesion Mutants Open
Archaea, like bacteria, use type IV pili to facilitate surface adhesion. Moreover, archaeal flagella—structures required for motility—share a common ancestry with type IV pili. While the characterization of archaeal homologs of bacterial t…
View article: Haloferax volcanii strategies to regulate type IV pilus dependent adhesion and microcolony formation
Haloferax volcanii strategies to regulate type IV pilus dependent adhesion and microcolony formation Open
Microorganisms can utilize type IV pili to initiate and maintain biofilms - microbial communities that provide protection against stressful conditions. Because environmental conditions change suddenly, microorganisms have evolved multiple …