Ricardo Allegri
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View article: Remote Digital Cognitive Assessment in a Trial-Ready Alzheimer’s Cohort: A Scalable Approach for Early Intervention Studies
Remote Digital Cognitive Assessment in a Trial-Ready Alzheimer’s Cohort: A Scalable Approach for Early Intervention Studies Open
Background: Early detection of cognitive decline in Alzheimer’s disease (AD), particularly in preclinical stages, is critical for evaluating therapeutic interventions. Traditional cognitive assessments often lack reliability and require le…
View article: Redes neuronales y funcionamiento cognitivo en la fragilidad: Una revisión sistemática de la literatura
Redes neuronales y funcionamiento cognitivo en la fragilidad: Una revisión sistemática de la literatura Open
La fragilidad se presenta como un factor de riesgo clave para la disfunción cognitiva en adultos mayores. El propósito de la revisión sistemática es sintetizar la evidencia disponible en los últimos 11 años sobre la relación entre la fragi…
View article: Rol de la neuro-inflamación en la fisiopatología de la enfermedad de Alzheimer
Rol de la neuro-inflamación en la fisiopatología de la enfermedad de Alzheimer Open
View article: A new nosology for neurodegenerative dementias: cognitive proteinopathies - Shifting from “Where” to “What”
A new nosology for neurodegenerative dementias: cognitive proteinopathies - Shifting from “Where” to “What” Open
Over the next 100 years, the neuropathology of each of these diseases was studied in greater detail. For instance, alpha-synuclein was identified in Parkinson's disease, beta-amyloid and phospho-tau in Alzheimer's disease, and tau and TDP-…
View article: New Alzheimer's disease diagnostic criteria 2024: Biological vs Clinical-biological criteria
New Alzheimer's disease diagnostic criteria 2024: Biological vs Clinical-biological criteria Open
Regarding the development of Alzheimer’s disease biomarkers, the diagnostic criteria for the disease have been modified. Up to now, they have only been used in research, but with the advent of new biological treatments with anti-amyloid an…
View article: Deficits of Alzheimer’s Disease Neuropsychological Architecture Correlate with Specific Exosomal mRNA Expression: Evidence of a Continuum?
Deficits of Alzheimer’s Disease Neuropsychological Architecture Correlate with Specific Exosomal mRNA Expression: Evidence of a Continuum? Open
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and complex molecular changes. Extracellular vesicles (EVs), particularly exosomes, play a key role in intercellular communication and disease prog…
View article: Generation of human induced pluripotent stem cell lines from two down syndrome patients, including a down syndrome/Alzheimer’s disease case (FLENIi002-A) and a beta-amyloid-resistant case (FLENIi003-A)
Generation of human induced pluripotent stem cell lines from two down syndrome patients, including a down syndrome/Alzheimer’s disease case (FLENIi002-A) and a beta-amyloid-resistant case (FLENIi003-A) Open
Two human induced pluripotent stem cell (hiPSC) lines, FLENIi002-A and FLENIi003-A, were generated from peripheral blood mononuclear cells (PBMCs) using the lentiviral-hSTEMCCA-loxP vector. FLENIi002-A was derived from a 52-year-old Down s…
View article: Behavioral variant frontotemporal dementia (bvFTD): PET biomarker characterization of metabolism (18F‐FDG), amyloid (11C‐PIB) and tau (18F‐AV1451) and its clinical correlate ‐ analysis of a cohort from Argentina
Behavioral variant frontotemporal dementia (bvFTD): PET biomarker characterization of metabolism (18F‐FDG), amyloid (11C‐PIB) and tau (18F‐AV1451) and its clinical correlate ‐ analysis of a cohort from Argentina Open
INTRODUCTION Imaging biomarkers are fundamental in diagnosing neurodegenerative diseases, but their use in FTD remains limited. This study examines PET biomarkers in Argentine bvFTD patients. METHODS We studied a cohort of bvFTD patients (…
View article: Impact of genetic counseling and testing in individuals at high risk of familial Alzheimer's disease from Latin America: a non‐randomized controlled trial
Impact of genetic counseling and testing in individuals at high risk of familial Alzheimer's disease from Latin America: a non‐randomized controlled trial Open
INTRODUCTION This study involved evaluating a tailored genetic counseling and testing (GCT) protocol for families at risk of autosomal dominant Alzheimer's disease (ADAD) in Latin America (LatAm), focusing on essential cultural and regiona…
View article: The landscape of autosomal-dominant Alzheimer’s disease: global distribution and age of onset
The landscape of autosomal-dominant Alzheimer’s disease: global distribution and age of onset Open
We present a comprehensive global analysis of genetic variants associated with autosomal-dominant Alzheimer’s disease (ADAD). A total of 550 variants in the APP, PSEN1 and PSEN2 genes were identified, of which 279 were classified as pathog…
View article: Etiologies of rapidly progressive dementias: A systematic review and meta-analysis of causes in worldwide and Latin America
Etiologies of rapidly progressive dementias: A systematic review and meta-analysis of causes in worldwide and Latin America Open
Background Rapidly progressive dementia (RPD) is a group of neurological diseases, where three etiologies are particularly relevant: neurodegenerative, prion and autoimmune encephalitis (AIE) diseases. Objective The aim of this study is to…
View article: Instruments and Measurement Scales for Cognitive Frailty in Midlife: A Systematic Literature Review from 2013 to 2023
Instruments and Measurement Scales for Cognitive Frailty in Midlife: A Systematic Literature Review from 2013 to 2023 Open
This study is a systematic review addressing cognitive frailty, measurement instruments, and their impact on comprehensive care for older adults between 2013 and 2023. It seeks to identify findings on the distribution of studies in relatio…
View article: Genetic Screening of Frontotemporal Dementia Patients from a Memory Clinic in Argentina
Genetic Screening of Frontotemporal Dementia Patients from a Memory Clinic in Argentina Open
Background Frontotemporal dementia (FTD) remains one of the most common forms of early‐onset dementia (45 to 65 years). FTD consists clinically and pathologically of a heterogeneous group of disorders characterized by progressive frontal a…
View article: Gender Differences in the Predictive Efficacy of Mayo‐PACC for Alzheimer's Disease Biomarkers: Results from a South American Cohort
Gender Differences in the Predictive Efficacy of Mayo‐PACC for Alzheimer's Disease Biomarkers: Results from a South American Cohort Open
Background With the increase in life expectancy and the rising prevalence of Alzheimer's Disease (AD), the integration of biomarkers for early diagnosis is crucial. The Mayo Preclinical Alzheimer's Cognitive Composite (Mayo‐PACC), encompas…
View article: Cardiovascular health is associated with social determinants of health in the LatAm‐FINGERS cohort
Cardiovascular health is associated with social determinants of health in the LatAm‐FINGERS cohort Open
Background Cardiovascular risk factors (CVRF) are among the main modifiable risk factors for dementia in Latin America (LA). Therefore, improving cardiovascular health (CVH) is one of the main objectives of the LatAm‐FINGERS trial, the lar…
View article: Multi‐modal AI screening for MCI and Alzheimer's Disease: results from an Argentine Cohort
Multi‐modal AI screening for MCI and Alzheimer's Disease: results from an Argentine Cohort Open
Background Early detection of Mild Cognitive Impairment (MCI) is crucial for effective prevention. Traditional methods like expert judgment, clinical evaluations, and manual linguistic analyses are now complemented by Artificial Intelligen…
View article: Brain Volumetric Trajectories in Down Syndrome and Autosomal Dominant Alzheimer Disease
Brain Volumetric Trajectories in Down Syndrome and Autosomal Dominant Alzheimer Disease Open
Background Alzheimer disease (AD) related cognitive decline occurs at relatively young ages in individuals with Down syndrome (DS, early‐mid 50s) and in those with autosomal dominant mutations (ADAD, 40‐50s). Both groups show similar patte…
View article: Case report: A 50 year‐old Down syndrome man exhibiting no Alzheimer’s disease biomarker profile nor cognitive impairment. Experience from the Argentine Initiative for the Study of Down syndrome and Alzheimer’s
Case report: A 50 year‐old Down syndrome man exhibiting no Alzheimer’s disease biomarker profile nor cognitive impairment. Experience from the Argentine Initiative for the Study of Down syndrome and Alzheimer’s Open
Background Down Syndrome (DS) is the most common genetic form of intellectual disability. In recent years, there has been a significant increase in the life expectancy of individuals with DS, currently reaching the age of 60 or over. Howev…
View article: Multi‐Component and Cognitive Skills Training in Mild Cognitive Impairment: Outcomes from a South American Study
Multi‐Component and Cognitive Skills Training in Mild Cognitive Impairment: Outcomes from a South American Study Open
Background Dementia represents a significant health challenge, with evidence suggesting that it can be potentially delayed or prevented through non‐pharmacological interventions. There are different types of non‐pharmacological interventio…
View article: Cognitive impairment, brain connectivity, and long‐Covid: understanding the complex interplay
Cognitive impairment, brain connectivity, and long‐Covid: understanding the complex interplay Open
Background The persisting cognitive symptoms observed in individuals after a Covid‐19 infection (long‐Covid) remain an enigmatic aspect of the disease. Clinical descriptions in the literature are dissimilar, suggesting more than one clinic…
View article: LatAm‐FINGERS: Navigating Diversity in the Engagement of a Subcontinental Trial for Dementia Prevention
LatAm‐FINGERS: Navigating Diversity in the Engagement of a Subcontinental Trial for Dementia Prevention Open
Background LatAm‐FINGERS is the first non‐pharmacological multicenter randomized clinical trial aimed at preventing cognitive impairment in Latin America. It encompasses twelve countries that collectively represent 45% of the territory in …
View article: Risk factors and baseline cognition. Preliminary results from the LatAm‐FINGERS cohort
Risk factors and baseline cognition. Preliminary results from the LatAm‐FINGERS cohort Open
Background LatAm‐FINGERS ‐ the first non‐pharmacological multicenter randomized clinical trial in Latin America ‐ is a valuable opportunity to study lifestyle in a heterogeneous and multiethnic population exposed to a large number of cardi…
View article: Cognitive characteristics in a Uruguayan cohort of healthy subjects with high educational level in risk of development dementia and its relation with ApoE genotype
Cognitive characteristics in a Uruguayan cohort of healthy subjects with high educational level in risk of development dementia and its relation with ApoE genotype Open
Background ApoE has been linked to individual differences in risk and resilience to neurodegeneration in normal aging. The ApoE4 genotype has been associated with an increased risk of developing late‐onset Alzheimer’s disease (age 65 and o…
View article: Genetic counseling and testing in individuals at high risk for familial Alzheimer’s Disease from Latin America
Genetic counseling and testing in individuals at high risk for familial Alzheimer’s Disease from Latin America Open
Background Genetic testing for individuals with dominantly inherited Alzheimer’s disease (DIAD) is now of greater relevance due to the existence of therapeutic trials available to this population. However, the impact and main drivers influ…
View article: Exploring Social Networks in the LatAmFINGERS Trial: The Importance of Pre‐Intervention Social Involvement
Exploring Social Networks in the LatAmFINGERS Trial: The Importance of Pre‐Intervention Social Involvement Open
Background LatAm‐FINGERS is a non‐pharmacological multicenter randomized clinical trial aimed at preventing cognitive impairment. The intervention advocates for a lifestyle change based on diet, exercise, risk factor control, cognitive tra…
View article: Navigating Dyslexia Diagnosis in Primary Progressive Aphasia within Transparent Languages: A Study in a Spanish‐Speaking Community
Navigating Dyslexia Diagnosis in Primary Progressive Aphasia within Transparent Languages: A Study in a Spanish‐Speaking Community Open
Background Surface dyslexia serves as a complementary feature in the classification of the semantic variant of Primary Progressive Aphasia (PPA), while reading deficits have also been reported in the other two PPA variants. In opaque langu…
View article: Inclusive Clinical Trials in Alzheimer’s Disease: A Latin American Perspective from LatAm FINGERS
Inclusive Clinical Trials in Alzheimer’s Disease: A Latin American Perspective from LatAm FINGERS Open
Background The LatAm‐FINGERS trial marks a pioneering initiative as the first non‐pharmacological clinical trial encompassing participants from 12 Latin American countries, including Argentina, Brazil, Bolivia, Chile, Colombia, Costa Rica,…
View article: Decentralised clinical trials for medications to reduce the risk of dementia: consensus report and guidance
Decentralised clinical trials for medications to reduce the risk of dementia: consensus report and guidance Open
Background Recent growth in the functionality and use of technology has prompted an increased interest in the potential for remote or decentralised clinical trials in dementia. There are many potential benefits associated with decentralise…
View article: A Decade‐Long Analysis of Dementia Incidence in Argentina: Insights from a Public Registry Study
A Decade‐Long Analysis of Dementia Incidence in Argentina: Insights from a Public Registry Study Open
Background Argentina is the second‐largest country in Latin America, home to 9% of the world’s Latino population. Like the rest of Latin America, it is grappling with the aging of its population and an increase in risk factors. Despite thi…
View article: Latent atrophy factors in Primary Progressive Aphasia due to Alzheimer´s disease and linguistic features, across different cultural settings
Latent atrophy factors in Primary Progressive Aphasia due to Alzheimer´s disease and linguistic features, across different cultural settings Open
Background Primary Progressive Aphasia (PPA) is a clinical entity that encompasses various neurodegenerative etiologies. Based on differential linguistic profiles, PPAhas been classified into three phenotypes (i.e., semantic [svPPA], non‐f…