Ricardo C. Calhelha
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View article: Analysis of the Phenolic Profile of Chelidonium majus L. and Its Combination with Sericin: Balancing Antimicrobial Activity and Cytocompatibility
Analysis of the Phenolic Profile of Chelidonium majus L. and Its Combination with Sericin: Balancing Antimicrobial Activity and Cytocompatibility Open
The incorporation of bioactive natural compounds into biomedical applications offers a promising route to enhance therapeutic efficacy while supporting sustainability. In this study, we investigated the synergistic potential of Sericin, a …
View article: Waste to wellness: hypocholesterolemic solutions from mushroom residues, boosting circular economy
Waste to wellness: hypocholesterolemic solutions from mushroom residues, boosting circular economy Open
View article: Exploring the therapeutic synergy: comprehensive assays unveil the potential of sericin and Chelidonium majus L. in developing a possible wound dressing
Exploring the therapeutic synergy: comprehensive assays unveil the potential of sericin and Chelidonium majus L. in developing a possible wound dressing Open
View article: Nutritional and Bioactive Characterization of Unconventional Food Plants for Sustainable Functional Applications
Nutritional and Bioactive Characterization of Unconventional Food Plants for Sustainable Functional Applications Open
Unconventional food plants (UFPs) are increasingly valued for their nutritional composition and bioactive potential. This study proposes a comprehensive characterization of the chemical and bioactive properties of Pereskia aculeata Miller …
View article: Acute Effects of Nitrate-Rich Beetroot Juice on Cardiovascular and Hemodynamic Responses to Flywheel Resistance Exercise: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial
Acute Effects of Nitrate-Rich Beetroot Juice on Cardiovascular and Hemodynamic Responses to Flywheel Resistance Exercise: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial Open
Background/Objectives: Beetroot juice is a popular nutritional resource in sports due to its ergogenic effects, promoting vasodilation, hypotension, improved energy efficiency, and reduced oxygen cost. However, its role in modulating the a…
View article: Electrospun polycaprolactone membranes functionalized with nanochitin for enhanced bioactivity in localized cancer photodynamic therapy
Electrospun polycaprolactone membranes functionalized with nanochitin for enhanced bioactivity in localized cancer photodynamic therapy Open
The encapsulation of photosensitizers (PSs) in electrospun membranes has emerged as a promising approach in photodynamic therapy (PDT) on tumor sites, overcoming the drawbacks associated with systemic administration. In this work, localize…
View article: Effect of Heat-Assisted and Ultrasound-Assisted Extraction Methods on the Phenolic Profile and Biological Activity of Thymus vulgaris L. Extracts
Effect of Heat-Assisted and Ultrasound-Assisted Extraction Methods on the Phenolic Profile and Biological Activity of Thymus vulgaris L. Extracts Open
This study compares the phenolic composition and antioxidant activity of extracts obtained using heat-assisted extraction (HAE) and ultrasound-assisted extraction (UAE), both optimized through response surface methodology (RSM), with the p…
View article: A biorefinery approach for the simultaneous obtention of essential oils, organic acids and polyphenols from citrus peels: Phytochemical characterization and bioactive potential
A biorefinery approach for the simultaneous obtention of essential oils, organic acids and polyphenols from citrus peels: Phytochemical characterization and bioactive potential Open
This investigation evaluates the valorization of citrus peels (lemon, tangerine, and orange) to recover both on-polar and polar fractions simultaneously. Citrus essential oils, abundant in limonene (74.4-33.7 %), exhibited great antioxidan…
View article: Synthesis of Tricyclic and Tetracyclic Lactone Derivatives of Thieno[2,3-b]pyrazine or Thieno[2,3-b]quinoline: Preliminary Antitumor and Antiparasitic Activity Evaluation
Synthesis of Tricyclic and Tetracyclic Lactone Derivatives of Thieno[2,3-b]pyrazine or Thieno[2,3-b]quinoline: Preliminary Antitumor and Antiparasitic Activity Evaluation Open
Tricyclic and tetracyclic lactone derivatives of thieno[2,3-b]pyrazine or thieno[2,3-b]quinoline, and 2H-pyrones were prepared using different methodologies. Pd/Cu-catalyzed Sonogashira coupling using Et3N as a base, of methyl 7-bromothien…
View article: Optimization of heat and ultrasound-assisted extraction of Eucalyptus globulus leaves reveals strong antioxidant and antimicrobial properties
Optimization of heat and ultrasound-assisted extraction of Eucalyptus globulus leaves reveals strong antioxidant and antimicrobial properties Open
The extraction of phenolic compounds from eucalyptus leaves was optimized using heat and ultrasound-assisted techniques, and the bioactive potential of the resulting extract was assessed. The independent variables, including time (t), solv…
View article: Valorisation of pumpkin by-products: Chemical composition and bioactive properties of pumpkin seeds, peels, and fibrous strands from different local landraces of Greece
Valorisation of pumpkin by-products: Chemical composition and bioactive properties of pumpkin seeds, peels, and fibrous strands from different local landraces of Greece Open
This study evaluated the fruit by-products (peels, seeds, and fibrous strands) from 11 pumpkin genotypes cultivated in Greece aiming to valorize them as natural sources of bioactive compounds. Five compounds, including (-)-epicatechin and …
View article: Soybean Flour Fortified with Gryllus assimilis Powder to Increase Iron Bioavailability Improves Gut Health and Oxidative Balance In Vivo
Soybean Flour Fortified with Gryllus assimilis Powder to Increase Iron Bioavailability Improves Gut Health and Oxidative Balance In Vivo Open
Background: Insects like Gryllus assimilis have an excellent nutritional profile, including iron. However, the bioavailability of this iron and its effects on intestinal health and oxidative balance remain unclear. To enhance acceptance, i…
View article: A Biorefinery Approach for the Simultaneous Obtention of Essential Oils, Organic Acids and Polyphenols from Citrus Peels: Phytochemical Characterization and Bioactive Potential
A Biorefinery Approach for the Simultaneous Obtention of Essential Oils, Organic Acids and Polyphenols from Citrus Peels: Phytochemical Characterization and Bioactive Potential Open
View article: Authenticity and Bioactive Markers Search in the Phenolic‐Rich Extracts of Asteraceae Medicinal Plants Through Integrative Computational Chemometrics
Authenticity and Bioactive Markers Search in the Phenolic‐Rich Extracts of Asteraceae Medicinal Plants Through Integrative Computational Chemometrics Open
The Asteraceae family has been of significant concern for ethnobotanical studies, thanks to its health‐promoting properties linked to a plethora of bioactive compounds, among which phenolic compounds play a critical role. In this work, a w…
View article: Optimizing Ultrasound-Assisted Extraction for Enhanced Yield of Bioactive Compounds from Vaccinum Myrtillus and Rubus Idaeus Bioresidues
Optimizing Ultrasound-Assisted Extraction for Enhanced Yield of Bioactive Compounds from Vaccinum Myrtillus and Rubus Idaeus Bioresidues Open
View article: Jatoba (Hymenaea courbaril L.) Pod Residue: A Source of Phenolic Compounds as Valuable Biomolecules
Jatoba (Hymenaea courbaril L.) Pod Residue: A Source of Phenolic Compounds as Valuable Biomolecules Open
This study aimed at investigating the chemical composition and a selected group of bioactivities of jatoba (Hymenaea courbaril L.) pod residue. An aqueous extract (deionized water; AE) and a hydroethanolic extract (ethanol: deionized water…
View article: Comprehensive analysis of soybean (Glycine max L.) by-products: Nutritional value, phenolic composition, and bioactive properties
Comprehensive analysis of soybean (Glycine max L.) by-products: Nutritional value, phenolic composition, and bioactive properties Open
View article: Gut Microbiota as an Endocrine Organ: Unveiling Its Role in Human Physiology and Health
Gut Microbiota as an Endocrine Organ: Unveiling Its Role in Human Physiology and Health Open
The gut microbiota, recognised for its vital functions in host health, operates as an endocrine organ, exerting systemic effects beyond the gastrointestinal tract. This “virtual organ” produces hormones that influence distal organs, includ…
View article: Development, characterization and stability of a novel sport drink based on thermal water, apple juice and hibiscus
Development, characterization and stability of a novel sport drink based on thermal water, apple juice and hibiscus Open
Isotonic drinks are sports beverages that replenish minerals and rapidly absorbable carbohydrates. We proposed to surpass traditional formulations of isotonic drinks by integrating thermal water, which remains unexploited as a source of el…
View article: Exploring the potential of Hermetia illucens larvae extracts: A promising approach for dermocosmetic formulations
Exploring the potential of Hermetia illucens larvae extracts: A promising approach for dermocosmetic formulations Open
View article: Chemical profile and bioactivities of industrial wastes from <i>Chenopodium quinoa</i> seed
Chemical profile and bioactivities of industrial wastes from <i>Chenopodium quinoa</i> seed Open
This study aimed to investigate the effect of extraction methods and solvents (Soxhlet and supercritical fluid extraction, SFE) on the chemical profile (gas chromatography [GC]/mass spectrometry and GC/flame ionization detection) and antim…
View article: Biochemical Composition of Pumpkin Seeds and Seed By-Products
Biochemical Composition of Pumpkin Seeds and Seed By-Products Open
The goal of the current work was to assess the nutritional profile and phytochemical properties of cucurbit (Cucurbita maxima L.) seeds, seed oils and oil extraction by-products (e.g., seed-cakes). Our results suggest a high nutritional va…
View article: Enhancing Wound Healing: A Comprehensive Review of Sericin and Chelidonium majus L. as Potential Dressings
Enhancing Wound Healing: A Comprehensive Review of Sericin and Chelidonium majus L. as Potential Dressings Open
Wound healing, a complex physiological process orchestrating intricate cellular and molecular events, seeks to restore tissue integrity. The burgeoning interest in leveraging the therapeutic potential of natural substances for advanced wou…
View article: Extraction of Bioactive Compounds from Rubus Idaeus Bioresidues: A Full Screening on Phenolic Composition and Bioactive Potential
Extraction of Bioactive Compounds from Rubus Idaeus Bioresidues: A Full Screening on Phenolic Composition and Bioactive Potential Open
Purpose Rubus idaeus cultivation has boosted productivity due to its high nutritional value. In consequence, waste production increased. The discarded biomass, including leaves and aerial components, can be transformed into valuable functi…
View article: Exploring Therapeutic Advances: A Comprehensive Review of Intestinal Microbiota Modulators
Exploring Therapeutic Advances: A Comprehensive Review of Intestinal Microbiota Modulators Open
The gut microbiota establishes a mutually beneficial relationship with the host starting from birth, impacting diverse metabolic and immunological processes. Dysbiosis, characterized by an imbalance of microorganisms, is linked to numerous…
View article: Detailed Phytochemical Composition, Cyto-/Hepatotoxicity, and Antioxidant/Anti-Inflammatory Profile of Moroccan Spices: A Study on Coriander, Caraway, and Mystical Cumin
Detailed Phytochemical Composition, Cyto-/Hepatotoxicity, and Antioxidant/Anti-Inflammatory Profile of Moroccan Spices: A Study on Coriander, Caraway, and Mystical Cumin Open
Coriander, caraway, and mystical cumin are famous for their aromatic properties and widely used in Moroccan cuisine. The nutritional/phytochemical composition of their seeds (used for food flavoring and preservation) were compared. Their a…
View article: Revitalising Riboflavin: Unveiling Its Timeless Significance in Human Physiology and Health
Revitalising Riboflavin: Unveiling Its Timeless Significance in Human Physiology and Health Open
Since the early twentieth century, research on vitamins has revealed their therapeutic potential beyond their role as essential micronutrients. Riboflavin, known as vitamin B2, stands out for its unique characteristics. Despite numerous st…
View article: Chemical and Bioactive Evaluation of Essential Oils from Edible and Aromatic Mediterranean Lamiaceae Plants
Chemical and Bioactive Evaluation of Essential Oils from Edible and Aromatic Mediterranean Lamiaceae Plants Open
The Lamiaceae family, which includes several well-known aromatic plants, is scientifically relevant due to its essential oils (EOs). In this work, four EOs from Mediterranean species, namely Origanum vulgare L., Rosmarinus officinalis L., …
View article: Chemical and Bioactive Properties of Red Rice with Potential Pharmaceutical Use
Chemical and Bioactive Properties of Red Rice with Potential Pharmaceutical Use Open
Red rice has been proposed as a super-food. Accordingly, the nutritional properties (AOAC), as well as its chemical composition, including sugars (HPLC-RI), organic acids (UFLC-PDA), tocopherols (HPLD-FD), and phenolic compounds (LC-DAD-ES…
View article: The Impact of Deficit Irrigation on the Agronomic Performance and Chemical Composition of Scolymus hispanicus L.
The Impact of Deficit Irrigation on the Agronomic Performance and Chemical Composition of Scolymus hispanicus L. Open
In the current study, the effects of drought stress on the growth and phytochemical profile of Scolymus hispanicus L. (a.k.a. golden thistle) were evaluated. Plants were treated with three irrigation regimes, e.g., plants that received onl…