Ricardo Saracco-Álvarez
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View article: The Interaction Between CRHBP and FKBP5 Genes and Childhood Trauma Increases the Risk of Suicide Attempt in Patients with Schizophrenia and Bipolar Disorder
The Interaction Between CRHBP and FKBP5 Genes and Childhood Trauma Increases the Risk of Suicide Attempt in Patients with Schizophrenia and Bipolar Disorder Open
Background/Objectives: Patients with psychotic disorders have a lifetime risk of suicide attempt (SA) of around 10 to 50%. Genetic variants in the corticotropin-releasing hormone-binding protein (CRHBP) and FK506-binding protein 5 (FKBP5) …
View article: Are Sociodemographic Characteristics Associated with Course of High Risk for Psychosis Symptoms at 12-Month Follow-Up?
Are Sociodemographic Characteristics Associated with Course of High Risk for Psychosis Symptoms at 12-Month Follow-Up? Open
It is important to address the needs of individuals at CHR-P in both schools and workplaces. This includes reducing stress and improving access to mental health care. Promoting social skills and fostering peer relationships can help build …
View article: IRT analysis of the BDI-II for early online depression detection: validation in a Mexican population
IRT analysis of the BDI-II for early online depression detection: validation in a Mexican population Open
Introduction Identifying factors associated with depression is crucial to addressing the global rise in mental health needs. The Beck Depression Inventory II (BDI-II) has shown robustness in assessing depression, even in digital contexts. …
View article: Predicting the Beneficial Effects of Cognitive Stimulation and Transcranial Direct Current Stimulation in Amnestic Mild Cognitive Impairment with Clinical, Inflammation, and Human Microglia Exposed to Serum as Potential Markers: A Double-Blind Placebo-Controlled Randomized Clinical Trial
Predicting the Beneficial Effects of Cognitive Stimulation and Transcranial Direct Current Stimulation in Amnestic Mild Cognitive Impairment with Clinical, Inflammation, and Human Microglia Exposed to Serum as Potential Markers: A Double-Blind Placebo-Controlled Randomized Clinical Trial Open
In amnestic mild cognitive impairment (aMCI), neuroinflammation evolves during disease progression, affecting microglial function and potentially accelerating the pathological process. Currently, no effective treatment exists, leading to e…
View article: No Sex-based Differences in Self-reported Empathy between Patients with Schizophrenia and Control Subjects
No Sex-based Differences in Self-reported Empathy between Patients with Schizophrenia and Control Subjects Open
Background: Schizophrenia, one of the most disabling disorders worldwide, is characterized by impaired empathy, which appears to be more common in women. Methods: This study aimed to compare empathy levels between control subjects and pati…
View article: Are BDNF and Stress Levels Related to Antidepressant Response?
Are BDNF and Stress Levels Related to Antidepressant Response? Open
Antidepressant response is a multifactorial process related to biological and environmental factors, where brain-derived neurotrophic factor (BDNF) may play an important role in modulating depressive and anxious symptoms. We aimed to analy…
View article: On Metacognition: Overconfidence in Word Recall Prediction and Its Association with Psychotic Symptoms in Patients with Schizophrenia
On Metacognition: Overconfidence in Word Recall Prediction and Its Association with Psychotic Symptoms in Patients with Schizophrenia Open
A two-factor account has been proposed as an explanatory model for the formation and maintenance of delusions. The first factor refers to a neurocognitive process leading to a significant change in subjective experience; the second factor …
View article: My Reasons for Living: A Descriptive Study of the Motives for Not Committing Suicide Among Patients Diagnosed With Schizophrenia
My Reasons for Living: A Descriptive Study of the Motives for Not Committing Suicide Among Patients Diagnosed With Schizophrenia Open
View article: On Metacognition: Overconfidence in Word Recall Prediction and Its Association with Psychotic Symptoms in Patients with Schizophrenia
On Metacognition: Overconfidence in Word Recall Prediction and Its Association with Psychotic Symptoms in Patients with Schizophrenia Open
A two-factor account has been proposed as an explanatory model for the formation and maintenance of delusions. The first factor refers to a neurocognitive process leading to a significant change in subjective experience; the second factor …
View article: Nonverbal Communication and Alexithymia in Schizophrenia Patients
Nonverbal Communication and Alexithymia in Schizophrenia Patients Open
Introduction: schizophrenia is accompanied by deficits such as alterations in social perception. Alexithymia, the impairment to express emotions or feelings, is an emotional communicative deficit common to schizophrenia. Objective: to eval…
View article: Human olfactory neural progenitor cells reveal differences in IL-6, IL-8, thrombospondin-1, and MCP-1 in major depression disorder and borderline personality disorder
Human olfactory neural progenitor cells reveal differences in IL-6, IL-8, thrombospondin-1, and MCP-1 in major depression disorder and borderline personality disorder Open
Background Discovering biological markers is essential for understanding and treating mental disorders. Despite the limitations of current non-invasive methods, neural progenitor cells from the olfactory epithelium (hNPCs-OE) have been emp…
View article: Workforce Characteristics for Psychological Care in Public Treatment Centers for Hiv in Mexico
Workforce Characteristics for Psychological Care in Public Treatment Centers for Hiv in Mexico Open
Introduction. The participation of psychologists in the therapeutic care of people living with HIV (PLWHA) is not clear, since their functions are only focused on accompaniment and not on pharmacological and therapeutic adherence, and care…
View article: Risperidone Decreases Expression of Serotonin Receptor-2A (5-HT2A) and Serotonin Transporter (SERT) but Not Dopamine Receptors and Dopamine Transporter (DAT) in PBMCs from Patients with Schizophrenia
Risperidone Decreases Expression of Serotonin Receptor-2A (5-HT2A) and Serotonin Transporter (SERT) but Not Dopamine Receptors and Dopamine Transporter (DAT) in PBMCs from Patients with Schizophrenia Open
Dopamine and serotonin receptors and transporters play an essential role in the pathophysiology of schizophrenia; changes in their expression have been reported in neurons and leukocytes. Each antipsychotic induces a unique pattern in leuk…
View article: The effect of stressful life events on the risk for psychosis: differences between Mexican at clinical and familial high risk
The effect of stressful life events on the risk for psychosis: differences between Mexican at clinical and familial high risk Open
Background Stressful life events (SLEs) in the development of early psychosis have been little studied in low-income countries. This study examines differences in the prevalence of SLEs in Mexican at clinical high risk (CHR) and those with…
View article: Adverse effects of antipsychotics on sleep in patients with schizophrenia. Systematic review and meta-analysis
Adverse effects of antipsychotics on sleep in patients with schizophrenia. Systematic review and meta-analysis Open
Introduction Our objective was to conduct a systematic review and meta-analysis of adverse effects on sleep in patients with schizophrenia receiving antipsychotic treatment. Methods A systematic search was performed in PubMed, Cochrane Cen…
View article: Aripiprazole versus brexpiprazole for people with schizophrenia
Aripiprazole versus brexpiprazole for people with schizophrenia Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the efficacy and tolerability of aripiprazole compared to brexpiprazole in people diagnosed with schizophrenia or schizophrenia‐like psychosi…
View article: A better way of life: The role of leisure activities on self-perceived health, perceived stress, confidence in stress management, and satisfaction with social support in psychiatrists and psychiatry trainees in Mexico
A better way of life: The role of leisure activities on self-perceived health, perceived stress, confidence in stress management, and satisfaction with social support in psychiatrists and psychiatry trainees in Mexico Open
Background Psychiatrists are at high risk of developing burnout and mental health problems mainly due to their emotionally demanding jobs, difficult working conditions, long working hours, and poor work-life balance. As leisure activities …
View article: Propiedades psicométricas de la Escala de Comportamiento Criminal y Violento en el Aula en adolescentes del sureste mexicano
Propiedades psicométricas de la Escala de Comportamiento Criminal y Violento en el Aula en adolescentes del sureste mexicano Open
La violencia en el ámbito escolar se ha convertido en un problema creciente que afecta a los adolescentes por los comportamientos perturbadores frecuentes y graves que acarrea. Ante esta situación se requiere contar con instrumentos con pr…
View article: Addictive disorders, psychiatric symptoms, and potentially traumatic events in individuals with disabilities
Addictive disorders, psychiatric symptoms, and potentially traumatic events in individuals with disabilities Open
Background/Objectives Individuals with disabilities (IWD) have a higher risk of potentially traumatic events (PTEs) either in childhood or adulthood, increasing the risk of suicide attempts, mental disorders, and substance use disorder. Th…
View article: “Reasons for living” in patients with schizophrenia.
“Reasons for living” in patients with schizophrenia. Open
Reasons for Living (RFL) are a construct allows identifying the reasons for not committing suicide. These reasons are based on significant aspects of life, on the commitment to some ideals which may inhibit the impulse of committing suicid…
View article: Clinical and Functional Differences Between Mexican Youth at Clinical High Risk for Psychosis and With Familial High Risk
Clinical and Functional Differences Between Mexican Youth at Clinical High Risk for Psychosis and With Familial High Risk Open
Few studies have explored the differences in clinical psychopathology between youth at high risk for psychosis and those at familial high risk for psychosis. This study seeks to describe and compare the sociodemographic, clinical, and func…
View article: Developing an App to Screen for Dual Disorders: A Tool for Improving Treatment Services in Mexico
Developing an App to Screen for Dual Disorders: A Tool for Improving Treatment Services in Mexico Open
Background: Previous studies in Mexico undertaken at residential facilities for treating substance use disorders (SUDs) reported that the prevalence of Dual Disorders (DDs) is over 65%. DDs pose a major challenge for the Mexican health sys…
View article: Genetic Analysis of the ZNF804A Gene in Mexican Patients With Schizophrenia, Schizoaffective Disorder and Bipolar Disorder 
Genetic Analysis of the ZNF804A Gene in Mexican Patients With Schizophrenia, Schizoaffective Disorder and Bipolar Disorder Open
Background: Evidence suggests that Schizophrenia (SCZ), Schizoaffective Disorder (SAD) and Bipolar Disorder (BPD) share genetic risk variants. ZNF804A gene has been associated with these disorders in different populations. The aim was to a…
View article: Neuropsychiatric Genetics of Psychosis in the Mexican Population: A Genome-Wide Association Study Protocol for Schizophrenia, Schizoaffective, and Bipolar Disorder Patients and Controls
Neuropsychiatric Genetics of Psychosis in the Mexican Population: A Genome-Wide Association Study Protocol for Schizophrenia, Schizoaffective, and Bipolar Disorder Patients and Controls Open
No large-scale genome-wide association studies (GWASs) of psychosis have been conducted in Mexico or Latin America to date. Schizophrenia and bipolar disorder in particular have been found to be highly heritable and genetically influenced.…
View article: Treatment of Patients with Recently Exacerbated Schizophrenia with Paliperidone Palmitate: A Pilot Study of Efficacy and Tolerability
Treatment of Patients with Recently Exacerbated Schizophrenia with Paliperidone Palmitate: A Pilot Study of Efficacy and Tolerability Open
Wagner F Gattaz,1 Ricardo Saracco-Alvarez,2 Claudiane Salles Daltio,3 Martinus T Van de Bilt,1 Jose Julian Ortegón,4 Sergio J Villaseñor-Bayardo,5 Mario Louzã,6 Helio Elkis,6 Bernardo Soares,7 Patricia Cabr…
View article: <p>Treatment of Patients with Recently Exacerbated Schizophrenia with Paliperidone Palmitate: A Pilot Study of Efficacy and Tolerability</p>
Treatment of Patients with Recently Exacerbated Schizophrenia with Paliperidone Palmitate: A Pilot Study of Efficacy and Tolerability Open
Paliperidone palmitate was efficacious in Latin American patients studied with an acute exacerbation and recent diagnosis of schizophrenia, and no new safety signals were identified.
View article: Facial emotion recognition and its association with symptom severity, functionality, and cognitive impairment in schizophrenia: preliminary results
Facial emotion recognition and its association with symptom severity, functionality, and cognitive impairment in schizophrenia: preliminary results Open
Introduction. There is evidence to suggest that individuals with schizophrenia have greater difficulty in recognizing facial emotions, which has been related to cognitive impairment and higher symptom severity in this disease and seems to …
View article: Development of the Mexican Version of the Empathy Quotient
Development of the Mexican Version of the Empathy Quotient Open
Introduction. Empathy is defined as the ability or process to identify and understand other person’s situation, feelings, and motives. These responses are essential for relationships and social behavior. Baron-Cohen et al. created the Empa…
View article: Association between prolactin serum levels and cognitive function in chronic schizophrenia patients
Association between prolactin serum levels and cognitive function in chronic schizophrenia patients Open
Introduction. Several studies have explored the relationship between serum prolactin levels, symptomatology, and cognitive dysfunction in individuals at high risk for psychosis and patients with a first psychotic episode. However, the rela…
View article: PROCESSING SPEED DIFFERENCES BETWEEN SCHIZOPHRENIA AND SCHIZOAFFECTIVE DISORDER: A PILOT STUDY
PROCESSING SPEED DIFFERENCES BETWEEN SCHIZOPHRENIA AND SCHIZOAFFECTIVE DISORDER: A PILOT STUDY Open
We aimed to compare processing speed (PS) and its subcomponents in schizophrenia (SC) and schizoaffective disorder (SA). Thirty-five patients were divided into two groups (SC=18; SA=17). PS tasks from the MATRICS Consensus Cognitive Batter…