Explanipedia

Growth Hormone-Releasing Hormone Antagonists Increase Radiosensitivity in Non-Small Cell Lung Cancer Cells Open

Iacopo Gesmundo, Francesca Pedrolli, F.R. Giglioli, Florian Jazaj, Giuseppina Granato , et al. · 2025

Growth hormone-releasing hormone (GHRH) antagonists exert antitumor functions in different experimental cancers. However, their role in combination with radiotherapy in non-small cell lung cancer (NSCLC) remains unknown. Therefore, we inve…

Mention to Prof. Andrew V. Schally Open

Riccarda Granata · 2025

Association between the use of proton pump inhibitors and serum PSA levels in the general U.S. population Open

Fabio Bioletto, Giorgio Calleris, Luigi Simone Aversa, Marco Oderda, Giancarlo Marra , et al. · 2025

Background Proton pump inhibitors (PPIs) are widely prescribed drugs that have been associated with increased prostate cancer (PCa) cell proliferation in vitro and worse oncological outcomes in vivo. However, data on their influence on PSA…

Il GHRH - Un neuropeptide non solo ipofisiotropo Open

Iacopo Gesmundo, Riccarda Granata · 2025

Sommario L’ormone ipotalamico growth hormone-releasing hormone (GHRH), oltre a promuovere il rilascio di GH da parte dell’adenoipofisi, esercita numerosi effetti a livello periferico. Diversi studi hanno infatti dimostrato importanti azion…

Author Correction: Growth hormone-releasing hormone and its analogues in health and disease Open

Riccarda Granata, Sheila Leone, Xianyang Zhang, Iacopo Gesmundo, Charlotte Steenblock , et al. · 2024

Growth hormone-releasing hormone antagonist MIA-602 inhibits inflammation induced by SARS-CoV-2 spike protein and bacterial lipopolysaccharide synergism in macrophages and human peripheral blood mononuclear cells Open

Giuseppina Granato, Iacopo Gesmundo, Francesca Pedrolli, Ramesh Kasarla, Laura Begani , et al. · 2023

COVID-19 is characterized by an excessive inflammatory response and macrophage hyperactivation, leading, in severe cases, to alveolar epithelial injury and acute respiratory distress syndrome. Recent studies have reported that SARS-CoV-2 s…

QRFP receptor in GtoPdb v.2023.1 Open

Didier Bagnol, Tom I. Bonner, Myrna Carlebur, Anthony P. Davenport, Stephen M. Foord , et al. · 2023

The human gene encoding the QRFP receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on the QRFP receptor [19]; QRFPR, formerly known as the Peptide P518 receptor), previously designated as an orphan GPCR receptor was identified…

Agonist of growth hormone-releasing hormone improves the disease features of spinal muscular atrophy mice Open

Marina Boido, Iacopo Gesmundo, Anna Caretto, Francesca Pedrolli, Roberta Schellino , et al. · 2023

Spinal muscular atrophy (SMA) is a severe autosomal recessive neuromuscular disease affecting children and young adults, caused by mutations of the survival motor neuron 1 gene ( SMN1 ). SMA is characterized by the degeneration of spinal a…

Antagonist of Growth Hormone-Releasing Hormone Potentiates the Antitumor Effect of Pemetrexed and Cisplatin in Pleural Mesothelioma Open

Iacopo Gesmundo, Francesca Pedrolli, Nicoletta Vitale, Alessia Bertoldo, Giulia Orlando , et al. · 2022

Pleural mesothelioma (PM) is an aggressive cancer with poor prognosis and no effective therapies, mainly caused by exposure to asbestos. Antagonists of growth hormone-releasing hormone (GHRH) display strong antitumor effects in many experi…

Thermomagnetic Resonance Effect of the Extremely Low Frequency Electromagnetic Field on Three-Dimensional Cancer Models Open

Loredana Bergandi, Umberto Lucia, Giulia Grisolia, Iris C. Salaroglio, Iacopo Gesmundo , et al. · 2022

In our recent studies, we have developed a thermodynamic biochemical model able to select the resonant frequency of an extremely low frequency electromagnetic field (ELF-EMF) specifically affecting different types of cancer, and we have de…

Antagonist of growth hormone-releasing hormone MIA-690 attenuates the progression and inhibits growth of colorectal cancer in mice Open

Lucia Recinella, Annalisa Chiavaroli, Serena Veschi, Valentina Di Valerio, Rossano Lattanzio , et al. · 2021

Editorial: Pathophysiological Interrelationship Between Obesity, Metabolic Diseases, and Cancer Open

Manuel D. Gahete, Riccarda Granata, Raúl M. Luque · 2021

insulin resistance or type-2 diabetes (T2D)], cardiovascular complications and some cancer types (4)(5)(6)(7)(8).Indeed, emerging evidence indicates that cancer development, progression, and aggressiveness are strongly influenced by the pr…

Antagonists of Growth Hormone-Releasing Hormone Inhibit the Growth of Pituitary Adenoma Cells by Hampering Oncogenic Pathways and Promoting Apoptotic Signaling Open

Iacopo Gesmundo, Giuseppina Granato, Antonio C. Fuentes-Fayos, Clara V. Álvarez, Carlos Diéguez , et al. · 2021

Pituitary adenomas (PAs) are intracranial tumors, often associated with excessive hormonal secretion and severe comorbidities. Some patients are resistant to medical therapies; therefore, novel treatment options are needed. Antagonists of …

Adipocyte-derived extracellular vesicles regulate survival and function of pancreatic β cells Open

Iacopo Gesmundo, Barbara Pardini, Eleonora Gargantini, Giacomo Gamba, Giovanni Birolo , et al. · 2021

Extracellular vesicles (EVs) are implicated in the crosstalk between adipocytes and other metabolic organs, and an altered biological cargo has been observed in EVs from human obese adipose tissue (AT). Yet, the role of adipocyte-derived E…

Protective effects of growth hormone-releasing hormone analogs in DSS-induced colitis in mice Open

Lucia Recinella, Annalisa Chiavaroli, Valentina Di Valerio, Serena Veschi, Giustino Orlando , et al. · 2021

Calcitriol Inhibits Viability and Proliferation in Human Malignant Pleural Mesothelioma Cells Open

Iacopo Gesmundo, Francesca Silvagno, Dana Banfi, Valentina Monica, Alessandro Fanciulli , et al. · 2020

Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor, often associated with exposure to asbestos and characterized by poor prognosis and limited treatment options. The biologically active form of vitamin D, calcitriol, exert…

SAT-603 Growth Hormone-Releasing Hormone (GHRH) Antagonists Stimulate Feeding in Mice Open

Sheila Leone, Lucia Recinella, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante , et al. · 2020

Growth hormone-releasing hormone (GHRH) is a hypothalamic neuropeptide which stimulates the synthesis and secretion of growth hormone (GH) in pituitary gland. GHRH was also found to modulate food intake in mammals. MIA-690 is a synthetic G…

Publisher Correction: Antinflammatory, antioxidant, and behavioral effects induced by administration of growth hormone-releasing hormone analogs in mice Open

Lucia Recinella, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Guya Diletta Marconi , et al. · 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Antinflammatory, antioxidant, and behavioral effects induced by administration of growth hormone-releasing hormone analogs in mice Open

Lucia Recinella, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Guya Diletta Marconi , et al. · 2020

Supplementary Material for: Statins Directly Regulate Pituitary Cell Function and Exert Antitumor Effects in Pituitary Tumors Open

María Carmen Vázquez-Borrego, Antonio C. Fuentes-Fayos, Aura D. Herrera‐Martínez, Eva Venegas‐Moreno, Fernando L‐López , et al. · 2020

Introduction: Pituitary neuroendocrine tumors (PitNETs), the most abundant of all intracranial tumors, entail severe comorbidities. First-line therapy is transsphenoidal surgery, but subsequent pharmacological therapy is ofte…

QRFP receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Open

Didier Bagnol, Tom I. Bonner, Myrna Carlebur, Anthony P. Davenport, Stephen M. Foord , et al. · 2019

The human gene encoding the QRFP receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on the QRFP receptor [16]; QRFPR, formerly known as the Peptide P518 receptor), previously designated as an orphan GPCR receptor was identified…

Editorial: Neuroendocrine Control of Feeding Behavior Open

Serge Luquet, Hubert Vaudry, Riccarda Granata · 2019

EDITORIAL article Front. Endocrinol., 19 June 2019Sec. Neuroendocrine Science Volume 10 - 2019 | https://doi.org/10.3389/fendo.2019.00399

The extremely low frequency electromagnetic stimulation selective for cancer cells elicits growth arrest through a metabolic shift Open

Loredana Bergandi, Umberto Lucia, Giulia Grisolia, Riccarda Granata, Iacopo Gesmundo , et al. · 2019

Actions and Potential Therapeutic Applications of Growth Hormone–Releasing Hormone Agonists Open

Andrew V. Schally, Xianyang Zhang, Renzhi Cai, Joshua M. Hare, Riccarda Granata , et al. · 2019

In this article, we briefly review the identification of GHRH, provide an abridged overview of GHRH antagonists, and focus on studies with GHRH agonists. Potent GHRH agonists of JI and MR class were synthesized and evaluated biologically. …

Antagonists of growth hormone-releasing hormone (GHRH) inhibit the growth of human malignant pleural mesothelioma Open

Tania Villanova, Iacopo Gesmundo, Valentina Audrito, Nicoletta Vitale, Francesca Silvagno , et al. · 2019

Significance Malignant pleural mesothelioma (MPM) is an aggressive cancer with poor prognosis and limited treatment options. MPM remains a serious public health problem, and novel therapeutic strategies are urgently needed. The antitumor p…

A Linear Fragment of Unacylated Ghrelin (UAG6−13) Protects Against Myocardial Ischemia/Reperfusion Injury in Mice in a Growth Hormone Secretagogue Receptor-Independent Manner Open

David N. Huynh, Hanan Elimam, Valérie L. Bessi, Liliane Ménard, Yan Burelle , et al. · 2019

Unacylated ghrelin (UAG), the most abundant form of ghrelin in circulation, has been shown to exert cardioprotective effect in experimental cardiopathies. The present study aimed to investigate the cardioprotective effect of a linear bioac…

Unacylated ghrelin prevents mitochondrial dysfunction in a model of ischemia/reperfusion liver injury Open

Alberto Rossetti, Gabriele Togliatto, Anabela P. Rolo, João S. Teodoro, Riccarda Granata , et al. · 2017

Ischemia/reperfusion (I/R) injury is a common cause of liver dysfunction during hepatectomy, liver transplantation procedures and in generalized shock. Although effort has been dedicated to rescuing tissue damage in these clinical settings…

Growth hormone-releasing hormone attenuates cardiac hypertrophy and improves heart function in pressure overload-induced heart failure Open

Iacopo Gesmundo, Michele Miragoli, Pierluigi Carullo, Letizia Trovato, Veronica Larcher , et al. · 2017

Significance Pathological cardiac hypertrophy, characterized by heart growth in response to pressure or volume overload, such as in the setting of hypertension, is the main risk factor for heart failure (HF). The identification of therapeu…

Obestatin regulates cardiovascular function and promotes cardioprotection through the nitric oxide pathway Open

Cláudia Penna, Francesca Tullio, Saveria Femminò, Carmine Rocca, Tommaso Angelone , et al. · 2017

Patients with ischaemic heart disease or chronic heart failure show altered levels of obestatin, suggesting a role for this peptide in human heart function. We have previously demonstrated that GH secretagogues and the ghrelin gene‐derived…

Role of Melatonin, Galanin, and RFamide Neuropeptides QRFP26 and QRFP43 in the Neuroendocrine Control of Pancreatic β-Cell Function Open

Iacopo Gesmundo, Tania Villanova, Dana Banfi, Giacomo Gamba, Riccarda Granata · 2017

Glucose homeostasis is finely regulated by a number of hormones and peptides released mainly from the brain, gastrointestinal tract, and muscle, regulating pancreatic secretion through cellular receptors and their signal transduction casca…

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