Riccardo Massimiliano Betto
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View article: STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia
STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia Open
View article: STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia
STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia Open
STAT3 and HIF1α are two fundamental transcription factors involved in many merging processes, like angiogenesis, metabolism, and cell differentiation. Notably, under pathological conditions, the two factors have been shown to interact gene…
View article: 3D ECM-rich environment sustains the identity of naive human iPSCs
3D ECM-rich environment sustains the identity of naive human iPSCs Open
View article: Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells
Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells Open
In human embryos, naive pluripotent cells of the inner cell mass generate epiblast, primitive endoderm and Trophectoderm (TE) lineage, whence trophoblast cells derive. In vitro , naive pluripotent stem cells (PSCs) retain this potential an…
View article: STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia
STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia Open
STAT3 and HIF1α are two fundamental transcription factors involved in many merging processes, like angiogenesis, metabolism, and cell differentiation. Notably, under pathological conditions, the two factors have been shown to interact gene…
View article: Metabolic control of DNA methylation in naive pluripotent cells
Metabolic control of DNA methylation in naive pluripotent cells Open
View article: Y705 and S727 are required for mitochondrial import and transcriptional activities of STAT3 and regulate proliferation of embryonic and tissue stem cells
Y705 and S727 are required for mitochondrial import and transcriptional activities of STAT3 and regulate proliferation of embryonic and tissue stem cells Open
The STAT3 transcription factor, acting both in the nucleus and mitochondria, maintains embryonic stem cell pluripotency and promotes their proliferation. In this work, using zebrafish, we determined in vivo that mitochondrial STAT3 regulat…
View article: Role of mitochondrial STAT3 in the metabolism of mouse embryonic stem cells
Role of mitochondrial STAT3 in the metabolism of mouse embryonic stem cells Open
Stat3 is a transcription factor activated by the cytokine LIF (leukemia inhibitory factor) in mouse embryonic stem (ES) cells. The LIF/Stat3 axis maintains ES cell self-renewal through the induction of nuclear target genes such as Klf4 and…