Riccardo Polani
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View article: Cefiderocol Resistance Conferred by Plasmid-Located Ferric Citrate Transport System in <i>Klebsiella pneumoniae</i> Carbapenemase<b>–</b>Producing <i>K. pneumoniae</i>
Cefiderocol Resistance Conferred by Plasmid-Located Ferric Citrate Transport System in <i>Klebsiella pneumoniae</i> Carbapenemase<b>–</b>Producing <i>K. pneumoniae</i> Open
Cefiderocol (FDC), a siderophore-cephalosporin conjugate, is the newest option for treating infection with carbapenem-resistant gram-negative bacteria. We identified a novel mechanism contributing to decreased FDC susceptibility in Klebsie…
View article: Development of a Providencia stuartii multilocus sequence typing scheme
Development of a Providencia stuartii multilocus sequence typing scheme Open
Introduction The Providencia genus is assuming greater clinical relevance among infections caused by Enterobacterales also because of its intrinsic and acquired resistance to last-resort antibiotics. However, despite having been known and …
View article: <i>In vivo</i> evolution to hypermucoviscosity and ceftazidime/avibactam resistance in a liver abscess caused by <i>Klebsiella pneumoniae</i> sequence type 512
<i>In vivo</i> evolution to hypermucoviscosity and ceftazidime/avibactam resistance in a liver abscess caused by <i>Klebsiella pneumoniae</i> sequence type 512 Open
Carbapenemase-producing Klebsiella pneumoniae represents a major public health issue globally. Isolates with resistance to the newest drugs, like ceftazidime/avibactam (CZA), are increasingly reported. In this study, we analyzed the evolut…
View article: Genotypic Evolution of <i>Klebsiella pneumoniae</i> Sequence Type 512 during Ceftazidime/Avibactam, Meropenem/Vaborbactam, and Cefiderocol Treatment, Italy
Genotypic Evolution of <i>Klebsiella pneumoniae</i> Sequence Type 512 during Ceftazidime/Avibactam, Meropenem/Vaborbactam, and Cefiderocol Treatment, Italy Open
In February 2022, a critically ill patient colonized with a carbapenem-resistant K. pneumoniae producing KPC-3 and VIM-1 carbapenemases was hospitalized for SARS-CoV-2 in the intensive care unit of Policlinico Umberto I hospital in Rome, I…
View article: Genetic background of neomycin resistance in clinical <i>Escherichia coli</i> isolated from Danish pig farms
Genetic background of neomycin resistance in clinical <i>Escherichia coli</i> isolated from Danish pig farms Open
Neomycin is the first-choice antibiotic for the treatment of porcine enteritis caused by enterotoxigenic Escherichia coli . Resistance to this aminoglycoside is on the rise after the increased use of neomycin due to the ban on zinc oxide. …
View article: Multiplicity of <i>bla</i> <sub>KPC</sub> Genes and pKpQIL Plasmid Plasticity in the Development of Ceftazidime-Avibactam and Meropenem Coresistance in Klebsiella pneumoniae Sequence Type 307
Multiplicity of <i>bla</i> <sub>KPC</sub> Genes and pKpQIL Plasmid Plasticity in the Development of Ceftazidime-Avibactam and Meropenem Coresistance in Klebsiella pneumoniae Sequence Type 307 Open
In 2021, Klebsiella pneumoniae sequence type 307 (ST307) strains causing pulmonary and bloodstream infections identified in a hospital in Rome, Italy, reached high levels of resistance to ceftazidime-avibactam (CZA). One of these strains r…
View article: Clinical Characteristics and Outcome of Ceftazidime/Avibactam-Resistant <i>Klebsiella pneumoniae</i> Carbapenemase–Producing <i>Klebsiella pneumoniae</i> Infections: A Retrospective, Observational, 2-Center Clinical Study
Clinical Characteristics and Outcome of Ceftazidime/Avibactam-Resistant <i>Klebsiella pneumoniae</i> Carbapenemase–Producing <i>Klebsiella pneumoniae</i> Infections: A Retrospective, Observational, 2-Center Clinical Study Open
Background Recently, Klebsiella pneumoniae carbapenemase (KPC)–producing Klebsiella pneumoniae (KPC-Kp) with resistance to ceftazidime/avibactam (CZA-R) has been described, including KPC variants that restore carbapenem susceptibility. The…
View article: Genome-Based Retrospective Analysis of a Providencia stuartii Outbreak in Rome, Italy: Broad Spectrum IncC Plasmids Spread the NDM Carbapenemase within the Hospital
Genome-Based Retrospective Analysis of a Providencia stuartii Outbreak in Rome, Italy: Broad Spectrum IncC Plasmids Spread the NDM Carbapenemase within the Hospital Open
Providencia stuartii is a member of the Morganellaceae family, notorious for its intrinsic resistance to several antibiotics, including last-resort drugs such as colistin and tigecycline. Between February and March 2022, a four-patient out…
View article: Ceftazidime–avibactam resistance in Klebsiella pneumoniae sequence type 37: a decade of persistence and concealed evolution
Ceftazidime–avibactam resistance in Klebsiella pneumoniae sequence type 37: a decade of persistence and concealed evolution Open
The first reports of carbapenem-resistant Enterobacterales in our hospital date back to 2006. In that period, few ertapenem-resistant but meropenem-susceptible Klebsiella pneumoniae isolates belonging to sequence type (ST) 37 were retrieve…