Riccardo Rocco Ferrari
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View article: Virtual biopsy through CT imaging: can radiomics differentiate between subtypes of non-small cell lung cancer?
Virtual biopsy through CT imaging: can radiomics differentiate between subtypes of non-small cell lung cancer? Open
View article: Brain donation rules in Italy and worldwide: overview of a cutting-edge topic for human brain research
Brain donation rules in Italy and worldwide: overview of a cutting-edge topic for human brain research Open
View article: Mitochondrial Alterations, Oxidative Stress, and Therapeutic Implications in Alzheimer’s Disease: A Narrative Review
Mitochondrial Alterations, Oxidative Stress, and Therapeutic Implications in Alzheimer’s Disease: A Narrative Review Open
The relationship between aging, mitochondrial dysfunction, neurodegeneration, and the onset of Alzheimer’s disease (AD) is a complex area of study. Aging is the primary risk factor for AD, and it is associated with a decline in mitochondri…
View article: A Map of Transcriptomic Signatures of Different Brain Areas in Alzheimer’s Disease
A Map of Transcriptomic Signatures of Different Brain Areas in Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a neurodegenerative disorder that progressively involves brain regions with an often-predictable pattern. Damage to the brain appears to spread and worsen with time, but the molecular mechanisms underlying the r…
View article: Functional analysis and transcriptome profile of meninges and skin fibroblasts from human‐aged donors
Functional analysis and transcriptome profile of meninges and skin fibroblasts from human‐aged donors Open
The central nervous system (CNS) is surrounded by three membranes called meninges. Specialised fibroblasts, originating from the mesoderm and neural crest, primarily populate the meninges and serve as a binding agent. Our goal was to compa…
View article: Homocysteinemia and Depression in Community-Dwelling Older Adults: The Cohort Longitudinal Study “InveCeAb” (Brain Aging in Abbiategrasso)
Homocysteinemia and Depression in Community-Dwelling Older Adults: The Cohort Longitudinal Study “InveCeAb” (Brain Aging in Abbiategrasso) Open
Depression is a major health problem, especially for elderly people. According to the “homocysteine hypothesis of depression”, high homocysteine levels may cause depression of mood via cerebrovascular diseases. Whilst biologically plausibl…
View article: APOE 5’UTR Methylation Pattern Analysis in Blood and Brain Tissue from Alzheimer’s Disease Affected Patients
APOE 5’UTR Methylation Pattern Analysis in Blood and Brain Tissue from Alzheimer’s Disease Affected Patients Open
APOE ɛ4 allele is the major genetic risk factor for Alzheimer's Disease (AD). Furthermore, APOE methylation pattern has been described to be associated with the disease and to follow a bimodal pattern, with a hypermethylated CpG island and…
View article: The role of the general practictioner in the management of urinary calculi
The role of the general practictioner in the management of urinary calculi Open
Background: The prevalence of kidney stones tends to increase worldwide due to dietary and climate changes. Disease management involves a high consumption of healthcare system resources which can be reduced with primary prevention measures…
View article: The decline of quantitative EEG goes along with neuropathology in Alzheimer’s Disease
The decline of quantitative EEG goes along with neuropathology in Alzheimer’s Disease Open
Background Few studies investigate the correlation between the quantitative EEG (QEEG) and the neuropathological picture. The purpose of this study is to explore how QEEG can recognize the type and extent of neuropathological changes. Meth…
View article: Transcriptomic profile across different brain areas in Alzheimer’s disease
Transcriptomic profile across different brain areas in Alzheimer’s disease Open
Background Aging is often characterized by a progressive loss of cognitive abilities due to the onset of Alzheimer Disease (AD). In recent years, ‐omic sciences have allowed us to begin to shed light on its molecular pathways in order to s…
View article: Mitochondria: between aging, frailty and sarcopenia
Mitochondria: between aging, frailty and sarcopenia Open
View article: COVID-19 Pathology in the Lung, Kidney, Heart and Brain: The Different Roles of T-Cells, Macrophages, and Microthrombosis
COVID-19 Pathology in the Lung, Kidney, Heart and Brain: The Different Roles of T-Cells, Macrophages, and Microthrombosis Open
Here, we aim to describe COVID-19 pathology across different tissues to clarify the disease’s pathophysiology. Lungs, kidneys, hearts, and brains from nine COVID-19 autopsies were compared by using antibodies against SARS-CoV-2, macrophage…