Richa Aishwarya
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View article: PathViT
PathViT Open
View article: AFTG-Net: A Deep Attention-based Fusion Framework of Topological and Gradient Features for Pathological Image Analysis
AFTG-Net: A Deep Attention-based Fusion Framework of Topological and Gradient Features for Pathological Image Analysis Open
Skeletal muscle pathology is observed by structural disruptions in sarcomeres, increased central nuclei, and changes in myofiber cross-sectional area. In order to classify amyotrophic lateral sclerosis (ALS), diabetes, and healthy controls…
View article: Septicemic melioidosis in a comorbid patient with familial history of tuberculosis: A case report with special reference to microbiological profile
Septicemic melioidosis in a comorbid patient with familial history of tuberculosis: A case report with special reference to microbiological profile Open
Burkholderia pseudomallei is a Gram-negative, facultative intracellular bacterium commonly found in the rhizosphere of tropical soils. It causes melioidosis, a disease that spreads through skin contact, ingestion, or inhalation of contamin…
View article: Transition from follicular lymphoma with cutaneous metastasis to diffuse large B cell lymphoma in ethnic skin: A rare case of aggressive transformation and spontaneous resolution by reverse koebnerization
Transition from follicular lymphoma with cutaneous metastasis to diffuse large B cell lymphoma in ethnic skin: A rare case of aggressive transformation and spontaneous resolution by reverse koebnerization Open
View article: Diastolic dysfunction in Alzheimer’s disease model mice is associated with Aβ-amyloid aggregate formation and mitochondrial dysfunction
Diastolic dysfunction in Alzheimer’s disease model mice is associated with Aβ-amyloid aggregate formation and mitochondrial dysfunction Open
View article: Trends in peripheral artery disease and critical limb ischemia hospitalizations among cocaine and methamphetamine users in the United States: a nationwide study
Trends in peripheral artery disease and critical limb ischemia hospitalizations among cocaine and methamphetamine users in the United States: a nationwide study Open
Background Peripheral artery disease (PAD) is on the rise worldwide, ranking as the third leading cause of atherosclerosis-related morbidity; much less is known about its trends in hospitalizations among methamphetamine and cocaine users. …
View article: Deletion of Sigmar1 leads to increased arterial stiffness and altered mitochondrial respiration resulting in vascular dysfunction
Deletion of Sigmar1 leads to increased arterial stiffness and altered mitochondrial respiration resulting in vascular dysfunction Open
Sigmar1 is a ubiquitously expressed, multifunctional protein known for its cardioprotective roles in cardiovascular diseases. While accumulating evidence indicate a critical role of Sigmar1 in cardiac biology, its physiological function in…
View article: Interactions between integrin α9β1 and VCAM-1 promote neutrophil hyperactivation and mediate poststroke DVT
Interactions between integrin α9β1 and VCAM-1 promote neutrophil hyperactivation and mediate poststroke DVT Open
Venous thromboembolic events are significant contributors to morbidity and mortality in patients with stroke. Neutrophils are among the first cells in the blood to respond to stroke and are known to promote deep vein thrombosis (DVT). Inte…
View article: Comparative Efficacy of Targeted Therapies in Treating Multiple Domains of Psoriatic Arthritis - A Single Center Study
Comparative Efficacy of Targeted Therapies in Treating Multiple Domains of Psoriatic Arthritis - A Single Center Study Open
Targeted therapies are commonly used in the management of Psoriatic arthritis (PsA). The Objective of our study is to investigate the comparative efficacy and safety of adalimumab (A), secukinumab(S) and tofacitinib(T) for patients with ac…
View article: OC 47.1 Neutrophil Integrin α9β1 Promotes Post-Stroke Deep Vein Thrombosis
OC 47.1 Neutrophil Integrin α9β1 Promotes Post-Stroke Deep Vein Thrombosis Open
expression in BMDMs in vitro via inhibition of Ifnb1.Additionally, they block type I interferon-and caspase-11-mediated pyroptosis, and subsequent TF release from BMDMs and TF-dependent thrombin generation.In vivo, DMF and 4-OI inhibit TF-…
View article: Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels
Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels Open
Sigma1 receptor protein (Sigmar1) is a small, multifunctional molecular chaperone protein ubiquitously expressed in almost all body tissues. This protein has previously shown its cardioprotective roles in rodent models of cardiac hypertrop…
View article: Pathological Sequelae Associated with Skeletal Muscle Atrophy and Histopathology in G93A*SOD1 Mice
Pathological Sequelae Associated with Skeletal Muscle Atrophy and Histopathology in G93A*SOD1 Mice Open
Amyotrophic lateral sclerosis (ALS) is a complex systemic disease that primarily involves motor neuron dysfunction and skeletal muscle atrophy. One commonly used mouse model to study ALS was generated by transgenic expression of a mutant f…
View article: Mitochondrial dysfunction and autophagy activation are associated with cardiomyopathy developed by extended methamphetamine self-administration in rats
Mitochondrial dysfunction and autophagy activation are associated with cardiomyopathy developed by extended methamphetamine self-administration in rats Open
View article: Visualizing Subcellular Localization of a Protein in the Heart Using Quantum Dots-Mediated Immuno-Labeling Followed by Transmission Electron Microscopy
Visualizing Subcellular Localization of a Protein in the Heart Using Quantum Dots-Mediated Immuno-Labeling Followed by Transmission Electron Microscopy Open
The subcellular localization is critical to delineating proper function and determining the molecular mechanisms of a particular protein. Several qualitative and quantitative techniques are used to determine the subcellular localization of…
View article: Visualizing Subcellular Localization of a Protein in the Heart Using Quantum Dots-Mediated Immuno-Labeling Followed by Transmission Electron Microscopy
Visualizing Subcellular Localization of a Protein in the Heart Using Quantum Dots-Mediated Immuno-Labeling Followed by Transmission Electron Microscopy Open
The subcellular localization is critical to delineating proper function and determining the molecular mechanisms of a particular protein. Several qualitative and quantitative techniques are used to determine the subcellular localization of…
View article: Monitoring Mitochondrial Morphology and Respiration in Doxorubicin-Induced Cardiomyopathy
Monitoring Mitochondrial Morphology and Respiration in Doxorubicin-Induced Cardiomyopathy Open
View article: The molecular role of Sigmar1 in regulating mitochondrial function through mitochondrial localization in cardiomyocytes
The molecular role of Sigmar1 in regulating mitochondrial function through mitochondrial localization in cardiomyocytes Open
Sigmar1 is a widely expressed molecular chaperone protein in mammalian cell systems. Accumulating research demonstrated the cardioprotective roles of pharmacologic Sigmar1 activation by ligands in preclinical rodent models of cardiac injur…
View article: Molecular Characterization of Skeletal Muscle Dysfunction in Sigma 1 Receptor (Sigmar1) Knockout Mice
Molecular Characterization of Skeletal Muscle Dysfunction in Sigma 1 Receptor (Sigmar1) Knockout Mice Open
View article: Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology
Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology Open
The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in Sigmar1 have been identified as a causative gene for …
View article: Skeletal muscle fiber-type switching, myopathy, and exercise intolerance in Sigmar1 null mice
Skeletal muscle fiber-type switching, myopathy, and exercise intolerance in Sigmar1 null mice Open
Sigmar1 is a widely expressed, multitasking molecular chaperone protein playing functional roles in several cellular processes. Mutations in the Sigmar1 gene have been reported to associate with several motor neuropathies, including amyotr…
View article: Histopathological Study of Endometrial Polyps and its Association With Cancer: Experience from a Tertiary Care Center in Coastal India
Histopathological Study of Endometrial Polyps and its Association With Cancer: Experience from a Tertiary Care Center in Coastal India Open
Aim: Morphologic examination of endometrial polyps and assess the occurrence of endometrial cancer. Materials & Methods: One hundred sixty cases of endometrial polyps received at the department of Pathology of a tertiary care hospital over…
View article: Dysfunctional Mitochondrial Dynamic and Oxidative Phosphorylation Precedes Cardiac Dysfunction in R120G‐αB‐Crystallin‐Induced Desmin‐Related Cardiomyopathy
Dysfunctional Mitochondrial Dynamic and Oxidative Phosphorylation Precedes Cardiac Dysfunction in R120G‐αB‐Crystallin‐Induced Desmin‐Related Cardiomyopathy Open
Background The mutated α‐B‐Crystallin (CryAB R120G ) mouse model of desmin‐related myopathy (DRM) shows an age‐dependent onset of pathologic cardiac remodeling and progression of heart failure. CryAB R120G expression in cardiomyocytes affe…
View article: Methamphetamine induces cardiomyopathy by Sigmar1 inhibition-dependent impairment of mitochondrial dynamics and function
Methamphetamine induces cardiomyopathy by Sigmar1 inhibition-dependent impairment of mitochondrial dynamics and function Open
View article: Chemical Architecture of Block Copolymers Differentially Abrogate Cardiotoxicity and Maintain the Anticancer Efficacy of Doxorubicin
Chemical Architecture of Block Copolymers Differentially Abrogate Cardiotoxicity and Maintain the Anticancer Efficacy of Doxorubicin Open
The molecular architecture of pH-responsive amphiphilic block copolymers, their self-assembly behavior to form nanoparticles (NPs), and doxorubicin (DOX)-loading technique govern the extent of DOX-induced cardiotoxicity. We observed that t…
View article: Molecular Perspectives of Mitochondrial Adaptations and Their Role in Cardiac Proteostasis
Molecular Perspectives of Mitochondrial Adaptations and Their Role in Cardiac Proteostasis Open
Mitochondria are the key to properly functioning energy generation in the metabolically demanding cardiomyocytes and thus essential to healthy heart contractility on a beat-to-beat basis. Mitochondria being the central organelle for cellul…
View article: Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes
Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes Open
Mitochondria are highly dynamic organelles that constantly undergo fission and fusion events to adapt to changes in the cellular environment. Aberrant mitochondrial fission has been associated with several types of cardiovascular dysfuncti…
View article: Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration
Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration Open
View article: Cardiac Dysfunction in the Sigma 1 Receptor Knockout Mouse Associated With Impaired Mitochondrial Dynamics and Bioenergetics
Cardiac Dysfunction in the Sigma 1 Receptor Knockout Mouse Associated With Impaired Mitochondrial Dynamics and Bioenergetics Open
Background The Sigma 1 receptor (Sigmar1) functions as an interorganelle signaling molecule and elicits cytoprotective functions. The presence of Sigmar1 in the heart was first reported on the basis of a ligand‐binding assay, and all studi…
View article: Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation–Induced Cardiac Proteotoxicity
Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation–Induced Cardiac Proteotoxicity Open
Background Desmin filament proteins interlink the contractile myofibrillar apparatus with mitochondria, nuclei and the sarcolemma. Mutations in the human desmin gene cause cardiac disease, remodeling, and heart failure but the pathophysiol…
View article: Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes
Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes Open
C/EBP-homologous protein (CHOP) is a ubiquitously expressed stress-inducible transcription factor robustly induced by maladaptive endoplasmic reticulum (ER) stresses in a wide variety of cells. Here, we examined a novel function of Sigma 1…