Richa Tiwary
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View article: Identification and characterization of a novel CD2-positive cell population in the seminiferous tubule of Fischer CDF344 rats
Identification and characterization of a novel CD2-positive cell population in the seminiferous tubule of Fischer CDF344 rats Open
We report the presence of a previously undocumented cell type in the spermatogonial stem cell niche expressing CD2 protein, using whole-mount immunofluorescence of rat seminiferous tubule preparations. Confocal imaging revealed that CD2+ c…
View article: Dose-dependent testis infiltration of peritubular macrophages after MEHP exposure of Peri-pubertal rats and their role in the recovery of spermatogenesis
Dose-dependent testis infiltration of peritubular macrophages after MEHP exposure of Peri-pubertal rats and their role in the recovery of spermatogenesis Open
We have previously reported that acute MEHP exposure resulted in a significant increase in peritubular macrophages along with differentiating spermatogonia. Here, we hypothesize that the recruitment of peritubular macrophages is MEHP dose-…
View article: The blood-testis barrier disruption is a prerequisite for toxicant-induced peritubular macrophage increases in the testis of peripubertal rats
The blood-testis barrier disruption is a prerequisite for toxicant-induced peritubular macrophage increases in the testis of peripubertal rats Open
Peritubular macrophages (PTMφ) are predominantly localized near spermatogonial stem cells in the testis. We previously revealed that exposure of peripubertal male Fischer rats to mono-(2-ethylhexyl) phthalate (MEHP) leads to increased PTMφ…
View article: Responses of peritubular macrophages and the testis transcriptome profiles of peripubertal and adult rodents exposed to an acute dose of MEHP
Responses of peritubular macrophages and the testis transcriptome profiles of peripubertal and adult rodents exposed to an acute dose of MEHP Open
Exposure of rodents to mono-(2-ethylhexyl) phthalate (MEHP) is known to disrupt the blood-testis barrier and cause testicular germ cell apoptosis. Peritubular macrophages (PTMφ) are a newly identified type of testicular macrophage that agg…
View article: Mono-(2-ethylhexyl) phthalate reversibly disrupts the blood-testis barrier in pubertal rats
Mono-(2-ethylhexyl) phthalate reversibly disrupts the blood-testis barrier in pubertal rats Open
The blood-testis barrier (BTB) is constituted by tight junctions between adjacent Sertoli cells (SCs) that create a specialized adluminal microenvironment to foster the development of spermatocytes and spermatids. The BTB is a well-studied…
View article: Peritubular Macrophages Are Recruited to the Testis of Peripubertal Rats After Mono-(2-Ethylhexyl) Phthalate Exposure and Is Associated With Increases in the Numbers of Spermatogonia
Peritubular Macrophages Are Recruited to the Testis of Peripubertal Rats After Mono-(2-Ethylhexyl) Phthalate Exposure and Is Associated With Increases in the Numbers of Spermatogonia Open
Peripubertal exposure of male rodents to the phthalate metabolite mono-(2-ethylhexyl) phthalate (MEHP) causes testicular inflammation, spermatocyte apoptosis, and disruption of the blood-testis barrier. The MEHP-induced inflammatory respon…
View article: MEHP-induced rat testicular inflammation does not exacerbate germ cell apoptosis
MEHP-induced rat testicular inflammation does not exacerbate germ cell apoptosis Open
The testis is an organ that maintains an immune suppressive environment. We previously revealed that exposure of pre-pubertal rats to an acute dose of a well-described Sertoli cell toxicant, mono-(2-ethylhexyl) phthalate (MEHP), leads to a…
View article: Lymphoid malignancies ARNT unstoppable
Lymphoid malignancies ARNT unstoppable Open
The aryl hydrocarbon receptor nuclear translocator (ARNT; also known as hypoxia inducible factor 1-β) is a member of the basic-helix-loop-helix-Per/ARNT/Sim (bHLH-PAS) family of transcription factors. ARNT is a common binding partner in th…
View article: Schematic diagram showing α-TEA to induce breast cancer cells to undergo apoptosis via caspase-8 mediated ER stress JNK/CHOP/DR5 amplification loop and by down-regulation of anti-apoptotic mediators c-FLIP (L) and Bcl-2.
Schematic diagram showing α-TEA to induce breast cancer cells to undergo apoptosis via caspase-8 mediated ER stress JNK/CHOP/DR5 amplification loop and by down-regulation of anti-apoptotic mediators c-FLIP (L) and Bcl-2. Open
Schematic diagram showing α-TEA to induce breast cancer cells to undergo apoptosis via caspase-8 mediated ER stress JNK/CHOP/DR5 amplification loop and by down-regulation of anti-apoptotic mediators c-FLIP (L) and Bcl-2.
View article: α-TEA decreased Bcl-2 and c-FLIP (L) protein levels via caspase-8 dependent ER stress-mediated JNK/CHOP/DR5 pathway.
α-TEA decreased Bcl-2 and c-FLIP (L) protein levels via caspase-8 dependent ER stress-mediated JNK/CHOP/DR5 pathway. Open
A. MDA-MB-231 and MCF-7 cells were treated with 40 µM α-TEA for 9, 15, and 24 hrs. Western blot analyses were performed to evaluate Bcl-2 and c-FLIP (L) protein levels with GADPH as loading control. B. MCF-7 cells were transiently transfec…