Richard Brogan
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View article: Endotyping-informed therapy for patients with chest pain and no obstructive coronary artery disease: a randomized trial
Endotyping-informed therapy for patients with chest pain and no obstructive coronary artery disease: a randomized trial Open
Patients undergoing invasive coronary angiography for the investigation of chest pain commonly do not have obstructive coronary artery disease. In contemporary practice, most of these individuals do not undergo functional diagnostic tests,…
View article: 207 Intracoronary adenosine derived coronary flow reserve and index of microvascular resistance
207 Intracoronary adenosine derived coronary flow reserve and index of microvascular resistance Open
Background and Aims Coronary function testing performed as an adjunct during invasive angiography, aids diagnosis of coronary microvascular dysfunction. Intravenous (IV) adenosine infusion for the induction of stable hyperaemia is the refe…
View article: 208 Contrast derived indices of coronary microvascular function
208 Contrast derived indices of coronary microvascular function Open
Background and Aims Coronary function testing to measure index of microcirculatory resistance (IMR) and coronary flow reserve (CFR) may be performed at the time of invasive coronary angiography to aid the diagnosis of microvascular angina.…
View article: 20 Ischaemic late gadolinium enhancement in patients with myocardial infarction and no obstructive coronary arteries
20 Ischaemic late gadolinium enhancement in patients with myocardial infarction and no obstructive coronary arteries Open
Introduction Myocardial infarction with no obstructive coronary arteries (MINOCA) occurs in approximately 1 in 9 presentations with acute coronary syndrome. Cardiac MRI is guideline indicated in the investigation of aetiology for MINOCA wh…
View article: Fractional Flow Reserve-Guided Stent Optimisation in Focal and Diffuse Coronary Artery Disease
Fractional Flow Reserve-Guided Stent Optimisation in Focal and Diffuse Coronary Artery Disease Open
Assessing coronary physiology after stent implantation facilitates the optimisation of percutaneous coronary intervention (PCI). Coronary artery disease (CAD) patterns can be characterised by the pullback pressure gradient (PPG) index. The…
View article: Angina After Percutaneous Coronary Intervention: Patient and Procedural Predictors
Angina After Percutaneous Coronary Intervention: Patient and Procedural Predictors Open
Background: Twenty percent to 40% of patients are affected by angina after percutaneous coronary intervention (PCI), which is associated with anxiety, depression, impaired physical function, and reduced quality of life. Understanding patie…
View article: 27 Rationale and design of the effect of mineralocorticoid receptor antagonist therapy in patients with acute myocardial infarction or injury and non-obstructive coronary arteries: a registry-based, stratified-medicine, randomised, controlled trial
27 Rationale and design of the effect of mineralocorticoid receptor antagonist therapy in patients with acute myocardial infarction or injury and non-obstructive coronary arteries: a registry-based, stratified-medicine, randomised, controlled trial Open
Background Myocardial infarction and non-obstructive coronary arteries (MINOCA) affects 1 in 9 patients with acute coronary syndrome. Vascular pathophysiology includes atherothrombosis and coronary vasomotion disorders. MINOCA has an unmet…
View article: Post-stenting fractional flow reserve vs coronary angiography for optimization of percutaneous coronary intervention (TARGET-FFR)
Post-stenting fractional flow reserve vs coronary angiography for optimization of percutaneous coronary intervention (TARGET-FFR) Open
Aims A fractional flow reserve (FFR) value ≥0.90 after percutaneous coronary intervention (PCI) is associated with a reduced risk of adverse cardiovascular events. TARGET-FFR is an investigator-initiated, single-centre, randomized controll…
View article: Post-operative myocardial infarction following aortic root surgery with coronary reimplantation: a case series treated with percutaneous coronary intervention
Post-operative myocardial infarction following aortic root surgery with coronary reimplantation: a case series treated with percutaneous coronary intervention Open
Background Coronary ostial stenosis is an uncommon but potentially lethal complication following aortic root replacement with or without aortic valve replacement (including Bentall and David procedures). This manifests clinically as acute …
View article: Incidence of Acute Bronchospasm during Systemic Adenosine Administration for Coronary Angiography
Incidence of Acute Bronchospasm during Systemic Adenosine Administration for Coronary Angiography Open
Background Adenosine is frequently used during coronary angiography to induce hyperaemia and allow operators to perform quantitative measurements of lesion severity. Acute bronchospasm is a recognised side effect relating to the activation…
View article: Relative survival and excess mortality following primary percutaneous coronary intervention for ST-elevation myocardial infarction
Relative survival and excess mortality following primary percutaneous coronary intervention for ST-elevation myocardial infarction Open
Background: High survival rates are commonly reported following primary percutaneous coronary intervention for ST-elevation myocardial infarction, with most contemporary studies reporting overall survival. Aims: The aim of this study was t…
View article: Patient and hospital determinants of primary percutaneous coronary intervention in England, 2003–2013
Patient and hospital determinants of primary percutaneous coronary intervention in England, 2003–2013 Open
Objective Primary percutaneous coronary intervention (PPCI) for ST-elevation myocardial infarction (STEMI) is insufficiently implemented in many countries. We investigated patient and hospital characteristics associated with PPCI utilisati…