Richard C. Boucher
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View article: Airway epithelial SARS-CoV-2 infectious and repair responses: relationships to age, sex, and post-COVID pulmonary syndromes
Airway epithelial SARS-CoV-2 infectious and repair responses: relationships to age, sex, and post-COVID pulmonary syndromes Open
The long-term pulmonary sequelae of SARS-CoV-2 respiratory infections reflect infection severity, innate and adaptive immunity, and respiratory epithelial repair. This study investigated the acute and reparative responses as a function of …
View article: Prolonged airway explant culture enables study of health, disease, and viral pathogenesis
Prolonged airway explant culture enables study of health, disease, and viral pathogenesis Open
In vitro models play a major role in studying airway physiology and disease. However, the native lung's complex tissue architecture and nonepithelial cell lineages are not preserved in these models. Ex vivo tissue models could overcome in …
View article: Prolonged airway explant culture enables study of health, disease, and viral pathogenesis
Prolonged airway explant culture enables study of health, disease, and viral pathogenesis Open
In vitro models play a major role in studying airway physiology and disease. However, the native lung’s complex tissue architecture and nonepithelial cell lineages are not preserved in these models. Ex vivo tissue models could overcome in …
View article: Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity
Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity Open
Coronaviruses (CoV) emerge suddenly from animal reservoirs to cause novel diseases in new hosts. Discovered in 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in camels in the Middle East and is continually cau…
View article: Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity
Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity Open
Coronaviruses (CoV) emerge suddenly from animal reservoirs to cause novel diseases in new hosts. Discovered in 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in camels in the Middle East and is continually cau…
View article: Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lung
Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lung Open
Airway multiciliated cells (MCs) maintain respiratory health by clearing mucus and trapped particles through the beating of motile cilia. While it is known that ciliary lengths decrease along the proximal-distal (P-D) axis of the tracheobr…
View article: Near fatal case of mirvetuximab soravtansine-gynx induced interstitial lung disease and a review of the primary literature
Near fatal case of mirvetuximab soravtansine-gynx induced interstitial lung disease and a review of the primary literature Open
•Mirvetuximab soravtansine-gynx should be recognized as a cause of drug-induced interstitial lung disease (ILD).•Radiographic manifestations of mirvetuximab soravtansine-gyn induced ILD include organizing pneumonia pattern.•Interstitial lu…
View article: Dysregulated Airway Host Defense in Hyper IgE Syndrome due to STAT3 Mutations
Dysregulated Airway Host Defense in Hyper IgE Syndrome due to STAT3 Mutations Open
Rationale Hyper IgE syndrome (STAT3-HIES), also known as Job’s syndrome, is a rare immunodeficiency disease typically caused by dominant-negative STAT3 mutations. STAT3-HIES syndrome is characterized by chronic pulmonary infection and infl…
View article: Near fatal case of mirvetuximab soravtansine-gynx induced interstitial lung disease and a review of the primary literature
Near fatal case of mirvetuximab soravtansine-gynx induced interstitial lung disease and a review of the primary literature Open
Folate receptor alpha (FRα) is a novel target for therapeutics that is over-expressed in solid tumor malignancies including ovarian, endometrial, and breast cancer and is expressed in non-malignant tissue such as alveolar cells (Scaranti e…
View article: SARS-CoV-2 variant of concern fitness and adaptation in primary human airway epithelia
SARS-CoV-2 variant of concern fitness and adaptation in primary human airway epithelia Open
To study viral replicative fitness of SARS-CoV-2 variants of concern in primary human airway cells.
View article: Vessel and Airway Characteristics in One-Year Computed Tomography–defined Rapid Emphysema Progression: SPIROMICS
Vessel and Airway Characteristics in One-Year Computed Tomography–defined Rapid Emphysema Progression: SPIROMICS Open
Rationale: Rates of emphysema progression vary in chronic obstructive pulmonary disease (COPD), and the relationships with vascular and airway pathophysiology remain unclear. Objectives: We sought to determine if indices of p…
View article: Prolonged airway explant culture enables study of health, disease, and viral pathogenesis
Prolonged airway explant culture enables study of health, disease, and viral pathogenesis Open
In vitro models play a major role in studying airway physiology and disease. However, the native lung’s complex tissue architecture and non-epithelial cell lineages are not preserved in these models. Ex vivo tissue models could overcome in…
View article: Design of the SPIROMICS Study of Early COPD Progression: SOURCE Study
Design of the SPIROMICS Study of Early COPD Progression: SOURCE Study Open
SOURCE should provide novel insights into the natural history of lung disease in younger individuals with a smoking history, and its biological basis.
View article: Longitudinal changes in the cystic fibrosis airway microbiota with time and treatment
Longitudinal changes in the cystic fibrosis airway microbiota with time and treatment Open
BACKGROUND: Whether there is any benefit in integrating culture-independent molecular analysis of the lower airway microbiota of people with cystic fibrosis into clinical care is unclear. This study determined the longitudinal trajectory o…
View article: Longitudinal changes in the cystic fibrosis airway microbiota with time and treatment
Longitudinal changes in the cystic fibrosis airway microbiota with time and treatment Open
The airway microbiota remains stable over periods <1 year with modest shifts related to treatment apparent which might provide some additional insights to patient-level measurements.
View article: Proximal and Distal Bronchioles Contribute to the Pathogenesis of Non–Cystic Fibrosis Bronchiectasis
Proximal and Distal Bronchioles Contribute to the Pathogenesis of Non–Cystic Fibrosis Bronchiectasis Open
Rationale: Non-cystic fibrosis bronchiectasis (NCFB) may originate in bronchiolar regions of the lung. Accordingly, there is a need to characterize the morphology and molecular characteristics of NCFB bronchioles. Objectives:…
View article: 193 Role of IL-1β in innate host defense of normal airway epithelia
193 Role of IL-1β in innate host defense of normal airway epithelia Open
View article: 201 SCGB3A2-positive distal airway secretory cells are a therapeutic target for CFTR function restoration
201 SCGB3A2-positive distal airway secretory cells are a therapeutic target for CFTR function restoration Open
View article: Inflammatory Activity of Epithelial Stem Cell Variants from Cystic Fibrosis Lungs Is Not Resolved by CFTR Modulators
Inflammatory Activity of Epithelial Stem Cell Variants from Cystic Fibrosis Lungs Is Not Resolved by CFTR Modulators Open
Rationale: CFTR (cystic fibrosis transmembrane conductance regulator) modulator drugs restore function to mutant channels in patients with cystic fibrosis (CF) and lead to improvements in body mass index and lung function. Although …
View article: Repeatability of Pulmonary Quantitative Computed Tomography Measurements in Chronic Obstructive Pulmonary Disease
Repeatability of Pulmonary Quantitative Computed Tomography Measurements in Chronic Obstructive Pulmonary Disease Open
"Repeatability of Pulmonary Quantitative Computed Tomography Measurements in Chronic Obstructive Pulmonary Disease." American Journal of Respiratory and Critical Care Medicine, 208(6), pp. 657–665
View article: Associations of COVID-19 symptoms with omicron subvariants BA.2 and BA.5, host status, and clinical outcomes in Japan: a registry-based observational study
Associations of COVID-19 symptoms with omicron subvariants BA.2 and BA.5, host status, and clinical outcomes in Japan: a registry-based observational study Open
View article: Development of a novel air–liquid interface airway tissue equivalent model for in vitro respiratory modeling studies
Development of a novel air–liquid interface airway tissue equivalent model for in vitro respiratory modeling studies Open
The human airways are complex structures with important interactions between cells, extracellular matrix (ECM) proteins and the biomechanical microenvironment. A robust, well-differentiated in vitro culture system that accurately models th…
View article: Development of a novel air–liquid interface airway tissue equivalent model for in vitro respiratory modeling studies
Development of a novel air–liquid interface airway tissue equivalent model for in vitro respiratory modeling studies Open
The human airways are complex structures with important interactions between cells, extracellular matrix (ECM) proteins and the biomechanical microenvironment. A robust, well-differentiated in vitro culture system that accurately models th…
View article: Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration
Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration Open
Unlike solid organs, human airway epithelia derive their oxygen from inspired air rather than the vasculature. Many pulmonary diseases are associated with intraluminal airway obstruction caused by aspirated foreign bodies, virus infection,…
View article: A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD
A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD Open
Accelerated progression of chronic obstructive pulmonary disease (COPD) is associated with increased risks of hospitalization and death. Prognostic insights into mechanisms and markers of progression could facilitate development of disease…
View article: A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD
A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD Open
View article: Bi-directional epithelial-immune communication amplifies inflammasome activation and IL-6 release during SARS-CoV-2 infection
Bi-directional epithelial-immune communication amplifies inflammasome activation and IL-6 release during SARS-CoV-2 infection Open
Increased levels of the pro-inflammatory cytokines IL-1β and IL-6 are linked to severe COVID-19. Here, we investigate the contributions of viral host cells, primary human airway epithelia (HAE), and immune bystanders, peripheral blood mono…
View article: Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48 h post infection
Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48 h post infection Open
View article: Associations of COVID-19 Symptoms with Omicron Subvariants BA.2 and BA.5, Host Status, and Clinical Outcomes: A Registry-Based Observational Study in Sapporo, Japan
Associations of COVID-19 Symptoms with Omicron Subvariants BA.2 and BA.5, Host Status, and Clinical Outcomes: A Registry-Based Observational Study in Sapporo, Japan Open
Background Previous SARS-CoV-2 infection and vaccination, coupled to rapid evolution of SARS-CoV-2 variants, have modified COVID-19 clinical manifestations. We characterized clinical symptoms of COVID-19 individuals in omicron BA.2 and BA.…
View article: Mucus Plugging and Regional Heterogeneity are Features of Asthmatic Small Airways
Mucus Plugging and Regional Heterogeneity are Features of Asthmatic Small Airways Open