Richard C. Crist
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View article: A nociceptive amygdala-striatal pathway modulating affective-motivational pain
A nociceptive amygdala-striatal pathway modulating affective-motivational pain Open
The basolateral amygdala (BLA) assigns valence to sensory stimuli, with a dedicated nociceptive ensemble encoding the negative valence of pain. However, the effects of chronic pain on the transcriptomic signatures and projection architectu…
View article: Ventral hippocampus neurons encode meal-related memory
Ventral hippocampus neurons encode meal-related memory Open
The ability to encode and retrieve meal-related information is critical to efficiently guide energy acquisition and consumption, yet the underlying neural processes remain elusive. Here we reveal that ventral hippocampus (HPCv) neuronal ac…
View article: Multi-ancestry genome-wide association meta-analysis of buprenorphine treatment response
Multi-ancestry genome-wide association meta-analysis of buprenorphine treatment response Open
View article: An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking
An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking Open
Recent studies show that systemic administration of a glucagon-like peptide-1 receptor (GLP-1R) agonist is sufficient to attenuate cocaine seeking. However, the neural mechanisms mediating these effects and the role of endogenous central G…
View article: SIV infection induces alterations in gene expression and loss of interneurons in Rhesus Macaque frontal cortex during early systemic infection
SIV infection induces alterations in gene expression and loss of interneurons in Rhesus Macaque frontal cortex during early systemic infection Open
Understanding the neurobiological mechanisms underlying HIV-associated neurocognitive decline in people living with HIV is frequently complicated by an inability to analyze changes across the course of the infection and frequent presence o…
View article: Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder
Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder Open
Importance Recently, the US Food and Drug Administration gave premarketing approval to an algorithm based on its purported ability to identify individuals at genetic risk for opioid use disorder (OUD). However, the clinical utility of the …
View article: Convergent state-control of endogenous opioid analgesia
Convergent state-control of endogenous opioid analgesia Open
Pain is a dynamic and nonlinear experience shaped by injury and contextual factors, including expectations of future pain or relief. While mu opioid receptors are central to the analgesic effects of opioid drugs, the endogenous opioid neur…
View article: A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens
A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens Open
View article: An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking
An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking Open
Recent studies show that systemic administration of a glucagon-like peptide-1 receptor (GLP-1R) agonist is sufficient to attenuate the reinstatement of cocaine-seeking behavior, an animal model of relapse. However, the neural mechanisms me…
View article: Clinical Pharmacogenetics Implementation Consortium Guideline for <i>CYP2B6</i> Genotype and Methadone Therapy
Clinical Pharmacogenetics Implementation Consortium Guideline for <i>CYP2B6</i> Genotype and Methadone Therapy Open
Methadone is a mu (μ) opioid receptor agonist used clinically in adults and children to manage opioid use disorder, neonatal abstinence syndrome, and acute and chronic pain. It is typically marketed as a racemic mixture of R ‐ and S ‐enant…
View article: A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens
A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens Open
Summary Neural processing of rewarding stimuli involves several distinct regions, including the nucleus accumbens (NAc). The majority of NAc neurons are GABAergic projection neurons known as medium spiny neurons (MSNs). MSNs are broadly de…
View article: Candidate Genes from an FDA-Approved Algorithm Fail to Predict Opioid Use Disorder Risk in Over 450,000 Veterans
Candidate Genes from an FDA-Approved Algorithm Fail to Predict Opioid Use Disorder Risk in Over 450,000 Veterans Open
Importance Recently, the Food and Drug Administration gave pre-marketing approval to algorithm based on its purported ability to identify genetic risk for opioid use disorder. However, the clinical utility of the candidate genes comprising…
View article: Mimicking opioid analgesia in cortical pain circuits
Mimicking opioid analgesia in cortical pain circuits Open
The anterior cingulate cortex is a key brain region involved in the affective and motivational dimensions of pain, yet how opioid analgesics modulate this cortical circuit remains unclear. Uncovering how opioids alter nociceptive neural dy…
View article: A nociceptive amygdala-striatal pathway for chronic pain aversion
A nociceptive amygdala-striatal pathway for chronic pain aversion Open
The basolateral amygdala (BLA) is essential for assigning positive or negative valence to sensory stimuli. Noxious stimuli that cause pain are encoded by an ensemble of noci ceptive BLA projection neurons (BLA noci ensemble). However, the …
View article: Ventral hippocampus neurons encode meal-related memory
Ventral hippocampus neurons encode meal-related memory Open
The ability to encode and retrieve meal-related information is critical to efficiently guide energy acquisition and consumption, yet the underlying neural processes remain elusive. Here we reveal that ventral hippocampus (HPCv) neuronal ac…
View article: Calcitonin receptor signaling in nucleus accumbens D1R- and D2R-expressing medium spiny neurons bidirectionally alters opioid taking in male rats
Calcitonin receptor signaling in nucleus accumbens D1R- and D2R-expressing medium spiny neurons bidirectionally alters opioid taking in male rats Open
View article: Placental microRNA methylome signatures may serve as biomarkers and therapeutic targets for prenatally opioid-exposed infants with neonatal opioid withdrawal syndrome
Placental microRNA methylome signatures may serve as biomarkers and therapeutic targets for prenatally opioid-exposed infants with neonatal opioid withdrawal syndrome Open
Introduction: The neonate exposed to opioids in utero faces a constellation of withdrawal symptoms postpartum commonly called neonatal opioid withdrawal syndrome (NOWS). The incidence of NOWS has increased in recent years due to the opioid…
View article: GIP receptor agonism blocks chemotherapy-induced nausea and vomiting
GIP receptor agonism blocks chemotherapy-induced nausea and vomiting Open
Our multispecies study defines a peptidergic system that represents a novel therapeutic target for the management of CINV, and potentially other drivers of nausea/emesis.
View article: GPR-160 Receptor Signaling in the Dorsal Vagal Complex of Male Rats Modulates Meal Microstructure and CART-Mediated Hypophagia
GPR-160 Receptor Signaling in the Dorsal Vagal Complex of Male Rats Modulates Meal Microstructure and CART-Mediated Hypophagia Open
The g-protein coupled receptor GPR-160, recently identified as a putative receptor for the cocaine and amphetamine-regulated transcript (CART) peptide, shows abundant expression in the energy-balance control nuclei, including the dorsal va…
View article: Identifying genetic loci and phenomic associations of substance use traits: A multi‐trait analysis of GWAS (MTAG) study
Identifying genetic loci and phenomic associations of substance use traits: A multi‐trait analysis of GWAS (MTAG) study Open
Background and Aims Genome‐wide association studies (GWAS) of opioid use disorder (OUD) and cannabis use disorder (CUD) have lagged behind those of alcohol use disorder (AUD) and smoking, where many more loci have been identified. We sough…
View article: Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment
Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment Open
Cancer metastasis to the brain is a significant clinical problem. Metastasis is the consequence of favorable interactions between invaded cancer cells and the microenvironment. Here, we demonstrate that cancer-activated astrocytes create a…
View article: Unraveling Psychiatric Disorders through Neural Single-Cell Transcriptomics Approaches
Unraveling Psychiatric Disorders through Neural Single-Cell Transcriptomics Approaches Open
The development of single-cell and single-nucleus transcriptome technologies is enabling the unraveling of the molecular and cellular heterogeneity of psychiatric disorders. The complexity of the brain and the relationships between differe…
View article: An intensive longitudinal examination of topiramate treatment for alcohol use disorder: a secondary analysis of data from a randomized controlled trial
An intensive longitudinal examination of topiramate treatment for alcohol use disorder: a secondary analysis of data from a randomized controlled trial Open
Background and Aims Previous findings have been equivocal as to whether a single‐nucleotide polymorphism (rs2832407) in GRIK1 , which encodes a glutamate receptor subunit, moderates the effects of topiramate treatment for drinking reductio…
View article: Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond
Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond Open
View article: Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction
Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction Open
View article: Single nucleus transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expression associated with volitional morphine intake
Single nucleus transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expression associated with volitional morphine intake Open
Opioid exposure is known to cause transcriptomic changes in the nucleus accumbens (NAc). However, no studies to date have investigated cell type-specific transcriptomic changes associated with volitional opioid taking. Here, we use single …
View article: Multi-trait Analysis of GWAS (MTAG) of Substance Use Traits Identifies Novel Genetic Loci and Phenomic Associations
Multi-trait Analysis of GWAS (MTAG) of Substance Use Traits Identifies Novel Genetic Loci and Phenomic Associations Open
Introduction A large majority of genome-wide significant (GWS) loci identified for substance use traits (SUTs) in genome-wide association studies (GWAS) have been for alcohol and smoking-related phenotypes. GWAS of opioid use disorder (OUD…
View article: Artificial Intelligence and Circulating Cell-Free DNA Methylation Profiling: Mechanism and Detection of Alzheimer’s Disease
Artificial Intelligence and Circulating Cell-Free DNA Methylation Profiling: Mechanism and Detection of Alzheimer’s Disease Open
Background: Despite extensive efforts, significant gaps remain in our understanding of Alzheimer’s disease (AD) pathophysiology. Novel approaches using circulating cell-free DNA (cfDNA) have the potential to revolutionize our understanding…
View article: Paternal nicotine taking elicits heritable sex-specific phenotypes that are mediated by hippocampal Satb2
Paternal nicotine taking elicits heritable sex-specific phenotypes that are mediated by hippocampal Satb2 Open
View article: Post‐treatment effects of topiramate on alcohol‐related outcomes: A combined analysis of two placebo‐controlled trials
Post‐treatment effects of topiramate on alcohol‐related outcomes: A combined analysis of two placebo‐controlled trials Open
Topiramate reduces drinking and alcohol‐related problems and is increasingly being used to treat alcohol use disorder (AUD). In a randomized controlled trial (RCT) of topiramate, rs2832407, a single nucleotide polymorphism (SNP) in the GRI…