Explanipedia

Enhanced neural plasticity in monkey TE compared to TEO during learning of a feature-ambiguous visual categorization task Open

Wenliang Wang, Bing Li, Narihisa Matsumoto, Kariely Martinez Gomez, Kazuko Hayashi , et al. · 2025

Primates can rapidly categorize images by visual feature similarity. We previously showed that inferior temporal cortex (IT) subregions TEO and TE contribute to visual categorization to differing extents. To investigate the neural plastici…

Differences in category information processing between areas TEO and TE of the macaque Open

Masaumi Shimizu, Shun Katakami, Masato Okada, Yasuko Sugase-Miyamoto, Kazuko Hayashi , et al. · 2025

Object categorization is a fundamental visual function, via which primates group items based on perceptual similarity. Neurons that respond to a class of complex objects, such as faces, can be found in inferior temporal cortex of macaque m…

Neural Correlates of Category Learning in Monkey Inferior Temporal Cortex Open

Jonah E Pearl, Narihisa Matsumoto, Kazuko Hayashi, Keiji Matsuda, Kenichiro Miura , et al. · 2024

Area TE is required for normal learning of visual categories based on perceptual similarity. To evaluate whether category learning changes neural activity in area TE, we trained two monkeys (both male) implanted with multielectrode arrays …

Cover Image, Volume 34, Issue 11 Open

Loïc J. Chareyron, W.K. Chong, Tina Banks, Neil Burgess, Richard C. Saunders , et al. · 2024

Anatomo‐functional changes in neural substrates of cognitive memory in developmental amnesia: Insights from automated and manual <span>Magnetic Resonance Imaging</span> examinations Open

Loïc J. Chareyron, W.K. Chong, Tina Banks, Neil Burgess, Richard C. Saunders , et al. · 2024

Despite bilateral hippocampal damage dating to the perinatal or early childhood period and severely impaired episodic memory, patients with developmental amnesia continue to exhibit well‐developed semantic memory across the developmental t…

Distinct roles of monkey OFC-subcortical pathways in adaptive behavior Open

Kei Oyama, Kei Majima, Yuji Nagai, Yukiko Hori, Toshiyuki Hirabayashi , et al. · 2024

Primates must adapt to changing environments by optimizing their behavior to make beneficial choices. At the core of adaptive behavior is the orbitofrontal cortex (OFC) of the brain, which updates choice value through direct experience or …

Hippocampal lesions impair non‐navigational spatial memory in macaques Open

Patrick A. Forcelli, Elyssa M. LaFlamme, Hannah F. Waguespack, Richard C. Saunders, Ludiše Málková · 2024

Decades of studies robustly support a critical role for the hippocampus in spatial memory across a wide range of species. Hippocampal damage produces clear and consistent deficits in allocentric spatial memory that requires navigating thro…

Neurons in the monkey frontopolar cortex encode learning stage and goal during a fast learning task Open

Simon Nougaret, Lorenzo Ferrucci, Francesco Ceccarelli, Stefano Sacchetti, Danilo Benozzo , et al. · 2024

The frontopolar cortex (FPC) is, to date, one of the least understood regions of the prefrontal cortex. The current understanding of its function suggests that it plays a role in the control of exploratory behaviors by coordinating the act…

Neural correlates of category learning in monkey inferior temporal cortex Open

Jonah E Pearl, Narihisa Matsumoto, Kazuko Hayashi, Keiji Matsuda, Kenichiro Miura , et al. · 2023

We trained two monkeys implanted with multi-electrode arrays to categorize natural images of cats and dogs, in order to observe changes in neural activity related to category learning. We recorded neural activity from area TE, which is req…

Distinct roles of monkey OFC-subcortical pathways in adaptive behavior Open

Kei Oyama, Kei Majima, Yuji Nagai, Yukiko Hori, Toshiyuki Hirabayashi , et al. · 2023

To be the most successful, primates must adapt to changing environments and optimize their behavior by making the most beneficial choices. At the core of adaptive behavior is the orbitofrontal cortex (OFC) of the brain, which updates choic…

Anatomo-functional changes in neural substrates of cognitive memory in developmental amnesia: Insights from automated and manual MRI examinations Open

Loïc J. Chareyron, W.K. Chong, Tina Banks, Neil Burgess, Richard C. Saunders , et al. · 2023

Despite bilateral hippocampal damage dating to perinatal or early-childhood period, and severely-impaired episodic memory that unfolds in later childhood, patients with developmental amnesia continue to exhibit well-developed semantic memo…

Chemogenetic Disconnection between the Orbitofrontal Cortex and the Rostromedial Caudate Nucleus Disrupts Motivational Control of Goal-Directed Action Open

Kei Oyama, Yukiko Hori, Koki Mimura, Yuji Nagai, Mark A. G. Eldridge , et al. · 2022

The orbitofrontal cortex (OFC) and its major downstream target within the basal ganglia-the rostromedial caudate nucleus (rmCD)-are involved in reward-value processing and goal-directed behavior. However, a causal contribution of the pathw…

Chemogenetic disconnection between the orbitofrontal cortex and the rostromedial caudate nucleus disrupts motivational control of goal-directed action Open

Kei Oyama, Yukiko Hori, Koki Mimura, Yuji Nagai, Mark A. G. Eldridge , et al. · 2022

The orbitofrontal cortex (OFC) and its major downstream target within the basal ganglia—the rostromedial caudate nucleus (rmCD)—are involved in reward-value processing and goal-directed behavior. However, a causal contribution of the pathw…

Mortimer Mishkin (1926–2021): A life of science with humility and grace Open

Bruno B. Averbeck, Arash Afraz, David A. Leopold, Richard C. Saunders, Elisabeth A. Murray , et al. · 2021

Contributions of the Monkey Inferior Temporal Areas TE and TEO to Visual Categorization Open

Tsuyoshi Setogawa, Mark A. G. Eldridge, Grace P. Fomani, Richard C. Saunders, Barry J. Richmond · 2021

The ability to categorize images is thought to depend on neural processing within the ventral visual stream. Recently, we reported that after removal of architectonic area TE, the terminal region of the ventral stream, monkeys were still a…

MRI monitoring of macaque monkeys in neuroscience: Case studies, resource and normative data comparisons Open

Fabien Balezeau, Jennifer Nacef, Yukiko Kikuchi, Felix Schneider, Francesca Rocchi , et al. · 2021

Theta, but Not Gamma Oscillations in Area V4 Depend on Input from Primary Visual Cortex Open

Ricardo Kienitz, Michele A. Cox, Kacie Dougherty, Richard C. Saunders, Joscha T. Schmiedt , et al. · 2020

An Open Resource for Non-human Primate Optogenetics Open

Sébastien Tremblay, Leah Acker, Arash Afraz, Daniel L. Albaugh, Hidetoshi Amita , et al. · 2020

Dimensionality, information and learning in prefrontal cortex Open

Ramón Bartolo, Richard C. Saunders, Andrew R. Mitz, Bruno B. Averbeck · 2020

Learning leads to changes in population patterns of neural activity. In this study we wanted to examine how these changes in patterns of activity affect the dimensionality of neural responses and information about choices. We addressed the…

Information-Limiting Correlations in Large Neural Populations Open

Ramón Bartolo, Richard C. Saunders, Andrew R. Mitz, Bruno B. Averbeck · 2020

Understanding the neural code requires understanding how populations of neurons code information. Theoretical models predict that information may be limited by correlated noise in large neural populations. Nevertheless, analyses based on t…

Dimensionality, information and learning in prefrontal cortex Open

Ramón Bartolo, Richard C. Saunders, Andrew R. Mitz, Bruno B. Averbeck · 2019

Learning leads to changes in population patterns of neural activity. In this study we wanted to examine how these changes in patterns of activity affect the dimensionality of neural responses and information about choices. We addressed the…

Colocalization of Tectal Inputs With Amygdala-Projecting Neurons in the Macaque Pulvinar Open

Catherine Elorette, Patrick A. Forcelli, Richard C. Saunders, Ludiše Málková · 2018

Neuropsychological and neuroimaging studies have suggested the presence of a fast, subcortical route for the processing of emotionally-salient visual information in the primate brain. This putative pathway consists of the superior collicul…

Perceptual processing in the ventral visual stream requires area TE but not rhinal cortex Open

Mark A. G. Eldridge, Narihisa Matsumoto, John H. Wittig, Evan C Masseau, Richard C. Saunders , et al. · 2018

There is an on-going debate over whether area TE, or the anatomically adjacent rhinal cortex, is the final stage of visual object processing. Both regions have been implicated in visual perception, but their involvement in non-perceptual f…

Theta Rhythmic Neuronal Activity and Reaction Times Arising from Cortical Receptive Field Interactions during Distributed Attention Open

Ricardo Kienitz, Joscha T. Schmiedt, Katharine A. Shapcott, Kleopatra Kouroupaki, Richard C. Saunders , et al. · 2018

Author response: Perceptual processing in the ventral visual stream requires area TE but not rhinal cortex Open

Mark A. G. Eldridge, Narihisa Matsumoto, John H. Wittig, Evan C Masseau, Richard C. Saunders , et al. · 2018

Rhythmic neural spiking and attentional sampling arising from cortical receptive field interactions Open

Ricardo Kienitz, Joscha T. Schmiedt, Katharine A. Shapcott, Kleopatra Kouroupaki, Richard C. Saunders , et al. · 2018

Summary Growing evidence suggests that distributed spatial attention may invoke theta (3-9 Hz) rhythmic sampling processes. The neuronal basis of such attentional sampling is however not fully understood. Here we show using array recording…

Maintained avalanche dynamics during task-induced changes of neuronal activity in nonhuman primates Open

Shan Yu, Tiago L. Ribeiro, Christian Meisel, Samantha Chou, Andrew R. Mitz , et al. · 2017

Sensory events, cognitive processing and motor actions correlate with transient changes in neuronal activity. In cortex, these transients form widespread spatiotemporal patterns with largely unknown statistical regularities. Here, we show …

Author response: Maintained avalanche dynamics during task-induced changes of neuronal activity in nonhuman primates Open

Shan Yu, Tiago L. Ribeiro, Christian Meisel, Samantha Chou, Andrew R. Mitz , et al. · 2017

Article Figures and data Abstract Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Sensory events, cognitive processing and motor actions corre…

Specialized Representations of Value in the Orbital and Ventrolateral Prefrontal Cortex: Desirability versus Availability of Outcomes Open

Peter H. Rudebeck, Richard C. Saunders, Dawn A. Lundgren, Elisabeth A. Murray · 2017

High channel count single-unit recordings from nonhuman primate frontal cortex Open

Andrew R. Mitz, Ramón Bartolo, Richard C. Saunders, Philip G. F. Browning, Thomas Talbot , et al. · 2017

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