Explanipedia

Exploring patient and clinician opinions, perspectives and acceptance of the use of artificial intelligence in the histological diagnosis of prostate cancer Open

Lisa Browning, Abhisek Ghosh, Monica Dolton, Kate Hutton, Jacqueline Birks , et al. · 2025

Objectives This study aims to explore the opinions and attitudes of patients and clinicians regarding the use of artificial intelligence (AI) in the diagnosis of prostate biopsies, with a focus on acceptance and trust in the use of AI, and…

Demographic and Clinical Characteristics of Pediculosis-associated Severe Anemia in the Emergency Department Open

William Plowe, Richard Colling, Sanjay Mohan, Rajneesh Gulati, Rana Biary , et al. · 2025

Introduction: Infestation with Pediculus species, or common lice, is frequently diagnosed in the emergency department (ED). Because lice ingest human blood, prolonged and heavy infestation can plausibly lead to iron deficiency anemia. Seve…

Detection of Genome‐Wide IGF ‐ 1R Recruitment to Enhancer and Promoter Regions of Chromatin in Clinical Prostate Cancers Open

Jack V. Mills, Avigail Taylor, Reema Singh, Jin-Seon Kim, Simon Engledow , et al. · 2025

Introduction Nuclear insulin‐like growth factor‐1 receptor (IGF‐1R) undergoes IGF‐induced recruitment to cancer cell chromatin in vitro and associates with advanced prostate cancer (PCa) stage in clinical tissue, prompting this investigati…

Does the extent of extraprostatic extension at radical prostatectomy predict outcome?—a systematic review and meta‐analysis Open

Lucia Lazzereschi, Jacqueline Birks, Richard Colling · 2024

Extraprostatic extension (EPE) of prostate cancer is usually reported as either focal (F‐EPE) or established (E‐EPE), but data on the implication for outcomes of this subdivision are conflicting and no systematic review (SR) evaluating thi…

Mapping the cited evidence of ductal carcinoma in situ from the 5th edition of the World Health Organisation classification of tumours of the breast Open

Clarissa Jing Wen Wong, Nur Diyana Md Nasir, Valerie Cui Yun Koh, Fiona Campbell, Stephen B. Fox , et al. · 2024

Aims Ductal carcinoma in situ (DCIS) is recognised by the World Health Organisation (WHO) Classification of Tumours (WCT) as a non‐invasive neoplastic epithelial proliferation confined to the mammary ducts and lobules. This report categori…

Prostate cancer detection after atypical small acinar proliferation (ASAP): A 10‐year single‐centre cohort Open

Thineskrishna Anbarasan, Mutie Raslan, Kanchan Ghosh, Philip S. Macklin, Clàudia Mercader , et al. · 2024

Atypical small acinar proliferation (ASAP), found in 5% of prostate biopsies, represents a focus of atypical cells that fall short of a cancer diagnosis.1 ASAP may be associated with a diagnosis of prostate cancer (PCa) upon repeat biopsy …

First-in-man study of the PSMA Minibody IR800-IAB2M for molecularly targeted intraoperative fluorescence guidance during radical prostatectomy Open

Freddie C. Hamdy, Alastair Lamb, Iain D. C. Tullis, Clare Verrill, Ines Rombach , et al. · 2024

Purpose Prostate-specific membrane antigen (PSMA) is increasingly used to image prostate cancer in clinical practice. We sought to develop and test a humanised PSMA minibody IAB2M conjugated to the fluorophore IRDye 800CW-NHS ester in men …

Moving Forward on Tumor Pathology Research Reporting: A Guide for Pathologists From the World Health Organization Classification of Tumors Living Evidence Gap Map by Tumour Type Group Open

Richard Colling, Iciar Indave, Javier Del Aguilla, Ramon Cierco Jiménez, Fiona Campbell , et al. · 2024

Evidence-based medicine (EBM) can be an unfamiliar territory for those working in tumor pathology research, and there is a great deal of uncertainty about how to undertake an EBM approach to planning and reporting histopathology-based stud…

Artificial Intelligence-Based Quality Assessment of Histopathology Whole-Slide Images within a Clinical Workflow: Assessment of ‘PathProfiler’ in a Diagnostic Pathology Setting Open

Lisa Browning, Christine Jesus, Stefano Malacrino, Yue Guan, Kieron White , et al. · 2024

Digital pathology continues to gain momentum, with the promise of artificial intelligence to aid diagnosis and for assessment of features which may impact prognosis and clinical management. Successful adoption of these technologies depends…

Analysis of 3D pathology samples using weakly supervised AI Open

Andrew H. Song, Mane Williams, Drew F. K. Williamson, Sarah S. L. Chow, Guillaume Jaume , et al. · 2024

Engineering the future of 3D pathology Open

Jonathan Liu, Sarah S. L. Chow, Richard Colling, Michelle R. Downes, Xavier Farré , et al. · 2023

In recent years, technological advances in tissue preparation, high‐throughput volumetric microscopy, and computational infrastructure have enabled rapid developments in nondestructive 3D pathology, in which high‐resolution histologic data…

A New Hierarchy of Research Evidence for Tumor Pathology: A Delphi Study to Define Levels of Evidence in Tumor Pathology Open

Richard Colling, Iciar Indave, Javier del Aguila, Ramon Cierco Jiménez, Fiona Campbell , et al. · 2023

The hierarchy of evidence is a fundamental concept in evidence-based medicine, but existing models can be challenging to apply in laboratory-based health care disciplines, such as pathology, where the types of evidence and contexts are sig…

Spatial transcriptomic analysis of virtual prostate biopsy reveals confounding effect of tissue heterogeneity on genomic signatures Open

Sandy Figiel, Wencheng Yin, Dimitrios Doultsinos, Andrew Erickson, Ninu Poulose , et al. · 2023

Genetic signatures have added a molecular dimension to prognostics and therapeutic decision-making. However, tumour heterogeneity in prostate cancer and current sampling methods could confound accurate assessment. Based on previously publi…

Department Wide Validation in Digital Pathology—Experience from an Academic Teaching Hospital Using the UK Royal College of Pathologists’ Guidance Open

Mai Kelleher, Richard Colling, Lisa Browning, Derek Roskell, Sharon Roberts-Gant , et al. · 2023

Aim: we describe our experience of validating departmental pathologists for digital pathology reporting, based on the UK Royal College of Pathologists (RCPath) “Best Practice Recommendations for Implementing Digital Pathology (DP),” at a l…

Correction: sFRP2 Supersedes VEGF as an Age-related Driver of Angiogenesis in Melanoma, Affecting Response to Anti-VEGF Therapy in Older Patients Open