Richard Dodel
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View article: Most prominent challenges in translational neuroscience and strategic solutions to bridge the gaps: Perspectives from an editorial board interrogation
Most prominent challenges in translational neuroscience and strategic solutions to bridge the gaps: Perspectives from an editorial board interrogation Open
Recent progress in translational neuroscience has significantly advanced our understanding of neurological diseases. Research progress closely went in line with innovations in research methods, which have expanded our insights considerably…
View article: Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease
Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease Open
Parkinson's disease (PD) is marked by motor symptoms and often accompanied by mild cognitive impairment (PD-MCI), affecting up to 50% of patients and preceding PD dementia (PDD). Genetic factors may influence this progression, yet the unde…
View article: Hypersomnolence in focus: a white paper of the 6th Think Tank World Sleep Forum
Hypersomnolence in focus: a white paper of the 6th Think Tank World Sleep Forum Open
An international expert group (European Sleep Foundation Think Tank) convened in 2022 to discuss the state of the evidence in the domain of hypersomnolence. The expert group considered the current state of knowledge based on the most relev…
View article: Parkinson disease – Prevalence, trends and regional patterns in Germany. An analysis based on routine data from the statutory health insurance
Parkinson disease – Prevalence, trends and regional patterns in Germany. An analysis based on routine data from the statutory health insurance Open
Measured by administrative prevalence, the significance of Parkinson disease for population health remains largely stable with a slight downward trend.
View article: Autoantibodies against α-synuclein inhibit its aggregation and cytotoxicity
Autoantibodies against α-synuclein inhibit its aggregation and cytotoxicity Open
Aggregates of α-synuclein (α-Syn) are the major component of the Lewy bodies associated with Parkinson's disease. Recently, naturally occurring autoantibodies against α-synuclein (α-Syn-nAbs) were detected. Herein we have isolated and furt…
View article: Preclinical CSF proteomic changes: a milestone in biomarker detection for autosomal dominant Alzheimer’s disease
Preclinical CSF proteomic changes: a milestone in biomarker detection for autosomal dominant Alzheimer’s disease Open
View article: A network perspective on cognition in individuals with Parkinson's disease
A network perspective on cognition in individuals with Parkinson's disease Open
INTRODUCTION In neuropsychological diagnostics, the assignment of cognitive tests to domains is usually not empirically based. Hence, we aimed to assess the dimensionality structure of cognition in individuals with Parkinson's disease (PD)…
View article: Epidemiology and Economic Burden of Sleep Disorders in Europe
Epidemiology and Economic Burden of Sleep Disorders in Europe Open
View article: Fractionated alpha and mixed beam radiation promote stronger pro-inflammatory effects compared to acute exposure and trigger phagocytosis
Fractionated alpha and mixed beam radiation promote stronger pro-inflammatory effects compared to acute exposure and trigger phagocytosis Open
Introduction and methods Aiming to evaluate safety aspects of a recently proposed approach to target Alzheimer’s disease, we mimicked a complex boron neutron capture therapy field using a mixed beam consisting of high- and low-linear energ…
View article: Autoantibody profiles in Alzheimer´s, Parkinson´s, and dementia with Lewy bodies: altered IgG affinity and IgG/IgM/IgA responses to alpha-synuclein, amyloid-beta, and tau in disease-specific pathological patterns
Autoantibody profiles in Alzheimer´s, Parkinson´s, and dementia with Lewy bodies: altered IgG affinity and IgG/IgM/IgA responses to alpha-synuclein, amyloid-beta, and tau in disease-specific pathological patterns Open
View article: Concussion in Female Athletes of Contact Sports: A Scoping Review
Concussion in Female Athletes of Contact Sports: A Scoping Review Open
Background: Recent studies have described higher incidences of concussion, with more severe symptoms and worse outcomes in female athletes compared with male athletes. Purpose: To compile current knowledge about sex-specific differences in…
View article: The Burden of Sleep/Wake Disorders: Excessive Daytime Sleepiness and Insomnia Project
The Burden of Sleep/Wake Disorders: Excessive Daytime Sleepiness and Insomnia Project Open
Excessive daytime sleepiness (EDS) and insomnia (IN) complaints represent the most common sleep/wake disorders. Currently, the specific needs of these patients and their relatives, as well as the overall socio-economic burden of IN and EDS…
View article: Systematic review-based guideline “Parkinson’s disease” of the German Society of Neurology: diagnostic use of transcranial sonography
Systematic review-based guideline “Parkinson’s disease” of the German Society of Neurology: diagnostic use of transcranial sonography Open
View article: Mid- and late-life lifestyle activities as main drivers of general and domain-specific cognitive reserve in individuals with Parkinson’s disease: cross-sectional and longitudinal evidence from the LANDSCAPE study
Mid- and late-life lifestyle activities as main drivers of general and domain-specific cognitive reserve in individuals with Parkinson’s disease: cross-sectional and longitudinal evidence from the LANDSCAPE study Open
View article: Factors associated with self-rated health in people with late-stage parkinson’s and cognitive impairment
Factors associated with self-rated health in people with late-stage parkinson’s and cognitive impairment Open
View article: Diagnosis and treatment of Parkinson´s disease (guideline of the German Society for Neurology)
Diagnosis and treatment of Parkinson´s disease (guideline of the German Society for Neurology) Open
View article: Which Comprehensive Geriatric Assessment (CGA) instruments are currently used in Germany: a survey
Which Comprehensive Geriatric Assessment (CGA) instruments are currently used in Germany: a survey Open
View article: Care of <scp>Late‐Stage</scp> Parkinsonism: Resource Utilization of the Disease in Five European Countries
Care of <span>Late‐Stage</span> Parkinsonism: Resource Utilization of the Disease in Five European Countries Open
Background Parkinson's disease (PD) is a neurodegenerative disease that leads to progressive disability. Cost studies have mainly explored the early stages of the disease, whereas late‐stage patients are underrepresented. Objective The aim…
View article: Repetitive head injuries in German American football players do not change blood-based biomarker candidates for CTE during a single season
Repetitive head injuries in German American football players do not change blood-based biomarker candidates for CTE during a single season Open
View article: Programme Dementia Prevention (pdp): A Nationwide Program for Personalized Prevention in Luxembourg
Programme Dementia Prevention (pdp): A Nationwide Program for Personalized Prevention in Luxembourg Open
Background: With continuously aging societies, an increase in the number of people with cognitive decline is to be expected. Aside from the development of causative treatments, the successful implementation of prevention strategies is of u…
View article: Smart technologies and textiles and their potential use and application in the care and support of elderly individuals: A systematic review
Smart technologies and textiles and their potential use and application in the care and support of elderly individuals: A systematic review Open
Demographic change is causing society to age. At the same time, technological progress is changing the way ageing individuals are cared for and medically treated. Several smart wearables and garments have recently been developed for this p…
View article: Demenz mit Lewy-Körpern: alte und neue Erkenntnisse – Teil 1: Klinik und Diagnostik
Demenz mit Lewy-Körpern: alte und neue Erkenntnisse – Teil 1: Klinik und Diagnostik Open
Zusammenfassung Hintergrund Die Demenz mit Lewy-Körpern (DLK) ist nach der Alzheimer-Krankheit die zweithäufigste neurodegenerative Demenzerkrankung. Patienten mit DLK haben oft eine schlechte Prognose, mit schlechteren Ergebnissen als Pat…
View article: Meaning in Life in Late-Stage Parkinson’s Disease: Results from the Care of Late-Stage Parkinsonism Study (CLaSP) in Six European Countries
Meaning in Life in Late-Stage Parkinson’s Disease: Results from the Care of Late-Stage Parkinsonism Study (CLaSP) in Six European Countries Open
View article: The impact of gender‐specific survival on the incidence of dementia in Parkinson’s disease ‐ A cohort analysis of Parkinson’s disease patients in German health claims data for the years 2006 to 2017
The impact of gender‐specific survival on the incidence of dementia in Parkinson’s disease ‐ A cohort analysis of Parkinson’s disease patients in German health claims data for the years 2006 to 2017 Open
Background The aim of our study is to analyze gender‐specific patterns of Parkinson’s disease dementia (PDD) incidence. In addition, we are investigating the extent to which gender differences in survival after initial Parkinson’s disease …
View article: The Impact of Sex‐Specific Survival on the Incidence of Dementia in Parkinson's Disease
The Impact of Sex‐Specific Survival on the Incidence of Dementia in Parkinson's Disease Open
Objective The aim of our study is to analyze sex‐specific patterns of Parkinson's disease dementia (PDD) incidence. We are investigating the extent to which sex differences in survival after initial Parkinson's disease (PD) diagnosis influ…
View article: The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson’s Disease
The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson’s Disease Open
The accumulation and aggregation of alpha-synuclein (α-Syn) are pathological processes associated with Parkinson’s disease, indicating that the regulation of protein is a crucial etiopathological mechanism. Interestingly, human serum and c…
View article: Fc N‐glycosylation of autoreactive Aβ antibodies as a blood‐based biomarker for Alzheimer's disease
Fc N‐glycosylation of autoreactive Aβ antibodies as a blood‐based biomarker for Alzheimer's disease Open
INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ 42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset. N‐glycans att…
View article: Author Correction: Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease
Author Correction: Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease Open
View article: Apathy in patients with Alzheimer's disease is a cost‐driving factor
Apathy in patients with Alzheimer's disease is a cost‐driving factor Open
Background Apathy is the most frequent neuropsychiatric symptom in patients with dementia of the Alzheimer's type (DAT). We analyzed the influence of apathy on the resource use of DAT patients and their caregivers. Methods Included were ba…
View article: Trial of Deferiprone in Parkinson’s Disease
Trial of Deferiprone in Parkinson’s Disease Open
In participants with early Parkinson's disease who had never received levodopa and in whom treatment with dopaminergic medications was not planned, deferiprone was associated with worse scores in measures of parkinsonism than those with pl…