Richard G. Bailey
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View article: Voiding in Parylene-C Encapsulation of Surface Mount LEDs for an Optogenetic Epilepsy Neuroprosthesis
Voiding in Parylene-C Encapsulation of Surface Mount LEDs for an Optogenetic Epilepsy Neuroprosthesis Open
It is often assumed that Parylene-C encapsulation films are void-free & conformal by nature of their vapour deposition. We present a case study in an optrode device where voiding occurs; we argue the voids originate from the geometry of th…
View article: Optogenetic Multiphysical Fields Coupling Model for Implantable Neuroprosthetic Probes
Optogenetic Multiphysical Fields Coupling Model for Implantable Neuroprosthetic Probes Open
Optogenetic-based neuroprosthetic therapies are increasingly being considered for human trials. However, the optoelectronic design of clinical-grade optogenetic-based neuroprosthetic probes still requires some thought. Design constraints i…
View article: Closed-loop optogenetic control of the dynamics of neural activity in non-human primates
Closed-loop optogenetic control of the dynamics of neural activity in non-human primates Open
View article: A Closed-Loop Optogenetic Platform
A Closed-Loop Optogenetic Platform Open
Neuromodulation is an established treatment for numerous neurological conditions, but to expand the therapeutic scope there is a need to improve the spatial, temporal and cell-type specificity of stimulation. Optogenetics is a promising ar…
View article: Closed-loop optogenetic control of normal and pathological network dynamics
Closed-loop optogenetic control of normal and pathological network dynamics Open
Electrical neurostimulation is effective in treating neurological disorders, but associated recording artefacts generally limit applications to ‘open-loop’ stimuli. Since light does not prevent concurrent electrical recordings, optogenetic…
View article: The Neural Engine: A Reprogrammable Low Power Platform for Closed-Loop Optogenetics
The Neural Engine: A Reprogrammable Low Power Platform for Closed-Loop Optogenetics Open
Brain-machine Interfaces (BMI) hold great potential for treating neurological disorders such as epilepsy. Technological progress is allowing for a shift from open-loop, pacemaker-class, intervention towards fully closed-loop neural control…
View article: Combining SPR with atomic-force microscopy enables single-molecule insights into activation and suppression of the complement cascade
Combining SPR with atomic-force microscopy enables single-molecule insights into activation and suppression of the complement cascade Open
Activation and suppression of the complement system compete on every serum-exposed surface, host or foreign. Potentially harmful outcomes of this competition depend on surface molecules through mechanisms that remain incompletely understoo…
View article: The role of polymers in cross-kingdom bioadhesion
The role of polymers in cross-kingdom bioadhesion Open
The secretion of extracellular polymeric substances provides an evolutionary advantage found in many organisms that can adhere to surfaces and cover themselves in a protective matrix. This ability is found in prokaryotes, archaea and eukar…
View article: Cell wall architecture and the development of cell shape in S. aureus and E. coli
Cell wall architecture and the development of cell shape in S. aureus and E. coli Open
View article: Bacterial Cell Enlargement Requires Control of Cell Wall Stiffness Mediated by Peptidoglycan Hydrolases
Bacterial Cell Enlargement Requires Control of Cell Wall Stiffness Mediated by Peptidoglycan Hydrolases Open
Most bacterial cells are enclosed in a single macromolecule of the cell wall polymer, peptidoglycan, which is required for shape determination and maintenance of viability, while peptidoglycan biosynthesis is an important antibiotic target…
View article: The mechanical properties of bacteria through the cell cycle as measured by atomic force microscopy
The mechanical properties of bacteria through the cell cycle as measured by atomic force microscopy Open
Staphylococcus aureus (SA) is a major cause of infection in humans, including the Methicillin resistant strain, MRSA. However, very little is known about the mechanical properties of these cells. The investigations presented in this thesis…