Richard Hébert
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View article: Canagliflozin Promotes Structural and Functional Changes in Proximal Tubular Cell Mitochondria of Hypertensive–Diabetic Mice
Canagliflozin Promotes Structural and Functional Changes in Proximal Tubular Cell Mitochondria of Hypertensive–Diabetic Mice Open
The kidneys have a high-energy demand, relying on great rates of mitochondrial oxidative phosphorylation. Excessive glucose in the tubules leads to defective fatty acid oxidation, playing a key role in tubular injury and diabetic kidney di…
View article: Sex-dependent effects of Canagliflozin on kidney protection in mice with combined hypertension-type 1 diabetes
Sex-dependent effects of Canagliflozin on kidney protection in mice with combined hypertension-type 1 diabetes Open
Canagliflozin (CANA) is a sodium-glucose cotransporter 2 (SGLT2) inhibitor with blood glucose lowering effects. CANA also promotes kidney protection in patients with cardiovascular diseases and type 2 diabetes (T2D), as well as in normogly…
View article: High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury
High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury Open
Chronic kidney disease (CKD) is a worldwide health burden with increases risk of end-stage renal function if left untreated. CKD induced in the context of metabolic syndrome (MS) increases risks of hypertension, hyperglycemia, excess body …
View article: Comparative analysis of hypertensive nephrosclerosis in animal models of hypertension and its relevance to human pathology. Glomerulopathy
Comparative analysis of hypertensive nephrosclerosis in animal models of hypertension and its relevance to human pathology. Glomerulopathy Open
Current research on hypertension utilizes more than fifty animal models that rely mainly on stable increases in systolic blood pressure. In experimental hypertension, grading or scoring of glomerulopathy in the majority of studies is based…
View article: POS-369 CHARACTERIZATION OF A NOVEL MOUSE MODEL OF METABOLIC SYNDROME INDUCED-CHRONIC KIDNEY DISEASE
POS-369 CHARACTERIZATION OF A NOVEL MOUSE MODEL OF METABOLIC SYNDROME INDUCED-CHRONIC KIDNEY DISEASE Open
Chronic kidney disease (CKD) induced in the context of metabolic syndrome (MS) involves underlying hypertension, hyperglycemia, excess body fat and dyslipidemia. A previously generated renin-dependent hypertensive/type-1 diabetic mouse mod…
View article: Head and Neck Squamous Cell Carcinoma Metastatic to the Orbital Apex
Head and Neck Squamous Cell Carcinoma Metastatic to the Orbital Apex Open
Primary squamous cell carcinoma of the head and neck most commonly metastasizes to the lymph nodes, lung, bone, and liver. Many other rare sites of metastatic disease have been reported. To date, metastatic squamous cell carcinoma of the h…
View article: P0710DUAL GPR40/GPR84 FATTY ACID RECEPTOR DELETION IMPROVES ADENINE-INDUCED RENAL INJURY IN MICE
P0710DUAL GPR40/GPR84 FATTY ACID RECEPTOR DELETION IMPROVES ADENINE-INDUCED RENAL INJURY IN MICE Open
Background and Aims Fatty acid receptors have recently been implicated in the progression of fibrotic disorders. GPR40 deletion predisposes to AKI and CKD-induced fibrosis, while deletion of the pro-inflammatory GPR84 receptor was benefici…
View article: Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice
Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice Open
Neuronal ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that maintains intracellular ubiquitin pools and promotes axonal transport. Uchl1 deletion in mice leads to progressive axonal degeneration, affecting the dors…
View article: Podocyte‐derived microparticles promote proximal tubule fibrotic signaling via p38 MAPK and CD36
Podocyte‐derived microparticles promote proximal tubule fibrotic signaling via p38 MAPK and CD36 Open
Tubulointerstitial fibrosis is a hallmark of advanced diabetic kidney disease that is linked to a decline in renal function, however the pathogenic mechanisms are poorly understood. Microparticles (MPs) are 100–1000 nm vesicles shed from i…
View article: Protein Kinase C-δ Mediates Shedding of Angiotensin-Converting Enzyme 2 from Proximal Tubular Cells
Protein Kinase C-δ Mediates Shedding of Angiotensin-Converting Enzyme 2 from Proximal Tubular Cells Open
Angiotensin-converting enzyme 2 (ACE2) degrades angiotensin (Ang) II to Ang-(1-7), and protects against diabetic renal injury. Soluble ACE2 fragments are shed from the proximal tubule, and appear at high levels in the urine with diabetes. …
View article: Endothelial Gata5 transcription factor regulates blood pressure
Endothelial Gata5 transcription factor regulates blood pressure Open
Despite its high prevalence and economic burden, the aetiology of human hypertension remains incompletely understood. Here we identify the transcription factor GATA5, as a new regulator of blood pressure (BP). GATA5 is expressed in microva…
View article: PGE2, Kidney Disease, and Cardiovascular Risk
PGE2, Kidney Disease, and Cardiovascular Risk Open
An important measure of cardiovascular health is obtained by evaluating the global cardiovascular risk, which comprises a number of factors, including hypertension and type 2 diabetes, the leading causes of illness and death in the world, …