Richard Holcomb
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View article: Interatrial Shunt Treatment for Heart Failure: The Randomized RELIEVE-HF Trial
Interatrial Shunt Treatment for Heart Failure: The Randomized RELIEVE-HF Trial Open
BACKGROUND: An interatrial shunt may provide an autoregulatory mechanism to decrease left atrial pressure and improve heart failure (HF) symptoms and prognosis. METHODS: Patients with symptomatic HF with any left ventricular ejection fract…
View article: <i>In vivo</i> fluid dynamics of the Ventura interatrial shunt device in patients with heart failure
<i>In vivo</i> fluid dynamics of the Ventura interatrial shunt device in patients with heart failure Open
Aims Interatrial shunts are under evaluation as a treatment for heart failure (HF); however, their in vivo flow performance has not been quantitatively studied. We aimed to investigate the fluid dynamics properties of the 0.51 cm orifice d…
View article: Characterizing Social Connectedness and Associated Mental Health Symptoms among Sexual Minority Men Enrolled in a Substance Use Recovery Support Program
Characterizing Social Connectedness and Associated Mental Health Symptoms among Sexual Minority Men Enrolled in a Substance Use Recovery Support Program Open
One-third of SMM enrolled in a substance use recovery program expressed relationship dissatisfaction, particularly those struggling with depression or anxiety. Future research and programming should examine ways of leveraging existing soci…
View article: Results of a Study Comparing Glycated Albumin to Other Glycemic Indices
Results of a Study Comparing Glycated Albumin to Other Glycemic Indices Open
Context Intermediate-term glycemic control metrics fulfill a need for measures beyond hemoglobin A1C. Objective Compare glycated albumin (GA), a 14-day blood glucose measure, with other glycemic indices. Design 24-week prospective study of…
View article: Orphan disease status of cancer cachexia in the USA and in the European Union: a systematic review
Orphan disease status of cancer cachexia in the USA and in the European Union: a systematic review Open
Background Cachexia has significant impact on the patients' quality of life and prognosis. It is frequently observed in patients with cancer, especially in advanced stages, but prevalence data for the overall population are lacking. Good q…
View article: Phrenic nerve stimulation to treat patients with central sleep apnoea and heart failure
Phrenic nerve stimulation to treat patients with central sleep apnoea and heart failure Open
Aims The presence of central sleep apnoea (CSA) is associated with poor prognosis in patients with heart failure (HF). The aim of this analysis was to evaluate if using phrenic nerve stimulation to treat CSA in patients with CSA and HF was…
View article: Sustained 12 Month Benefit of Phrenic Nerve Stimulation for Central Sleep Apnea
Sustained 12 Month Benefit of Phrenic Nerve Stimulation for Central Sleep Apnea Open
Transvenous phrenic nerve stimulation improved sleep metrics and quality of life after 6 months versus control in the remedē System Pivotal Trial. This analysis explored the effectiveness of phrenic nerve stimulation in patients with centr…
View article: Effect of Ularitide on Cardiovascular Mortality in Acute Heart Failure
Effect of Ularitide on Cardiovascular Mortality in Acute Heart Failure Open
In patients with acute heart failure, ularitide exerted favorable physiological effects (without affecting cardiac troponin levels), but short-term treatment did not affect a clinical composite end point or reduce long-term cardiovascular …
View article: Independent academic Data Monitoring Committees for clinical trials in cardiovascular and cardiometabolic diseases
Independent academic Data Monitoring Committees for clinical trials in cardiovascular and cardiometabolic diseases Open
Data Monitoring Committees ( DMCs ) play a crucial role in the conducting of clinical trials to ensure the safety of study participants and to maintain a trial's scientific integrity. Generally accepted standards exist for DMC composition …
View article: Rationale for and design of the <scp>TRUE‐AHF</scp> trial: the effects of ularitide on the short‐term clinical course and long‐term mortality of patients with acute heart failure
Rationale for and design of the <span>TRUE‐AHF</span> trial: the effects of ularitide on the short‐term clinical course and long‐term mortality of patients with acute heart failure Open
The TRUE‐AHF is a randomized, double‐blind, parallel‐group, placebo‐controlled trial which is evaluating the effects of a 48‐h infusion of ularitide (15 ng/kg/min) on the short‐ and long‐term clinical course of patients with acute heart fa…
View article: Erratum to “Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency” [Eur J Heart Fail 2016;18:482‐489]
Erratum to “Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency” [Eur J Heart Fail 2016;18:482‐489] Open
The publisher regrets that in the review article, Prof. Stefan D. Anker and Prof. Stefan Schroeder's affiliation were incorrectly published. The corrected version can be found above. Apologies for any inconvenience caused.
View article: Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency
Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency Open
Composite endpoints are commonly used as the primary measure of efficacy in heart failure clinical trials to assess the overall treatment effect and to increase the efficiency of trials. Clinical trials still must enrol large numbers of pa…
View article: Early Detection of Lung Cancer with Meso Tetra (4-Carboxyphenyl) Porphyrin-Labeled Sputum
Early Detection of Lung Cancer with Meso Tetra (4-Carboxyphenyl) Porphyrin-Labeled Sputum Open
The tetra (4-carboxyphenyl) porphyrin -based CyPath assay correctly classified study participants into cancer or high-risk cohorts with considerable accuracy. Optimizing sputum collection, sample reading, and refining the classifier should…
View article: Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea
Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea Open
Transvenous, unilateral phrenic nerve stimulation appears safe and effective for treating CSA. These findings should be confirmed in a prospective, randomized, controlled trial. (Chronic Evaluation of Respicardia Therapy; NCT01124370).
View article: The Association of Health Status and Providing Consent to Continued Participation in an Out‐of‐hospital Cardiac Arrest Trial Performed Under Exception From Informed Consent
The Association of Health Status and Providing Consent to Continued Participation in an Out‐of‐hospital Cardiac Arrest Trial Performed Under Exception From Informed Consent Open
Objectives Emergency medical research performed under federal regulation 21 § CFR 50.24 provides a means to protect human subjects and investigate novel time‐sensitive treatments. Although prospective individual consent is not required for…