Richard I. Gregory
YOU?
Author Swipe
View article: METTL3-dependent m6A RNA methylation suppresses aberrant mammary epithelial differentiation and neoplastic transformation
METTL3-dependent m6A RNA methylation suppresses aberrant mammary epithelial differentiation and neoplastic transformation Open
The mechanisms underlying sustained proliferation and aberrant cellular plasticity that drive early breast tumorigenesis remain unclear. Using CRISPR knockout (KO) screens, we systematically characterized the regulators of cellular fitness…
The tRNA Editing Complex ADAT2/3 Promotes Cancer Cell Growth and Codon-biased mRNA Translation Open
Transfer RNAs (tRNAs) are subject to various chemical modifications that influence their stability or function. Adenosine to Inosine (A-to-I) editing in the tRNA anticodon at position A34 is an important modification that expands anticodon…
View article: RNA methylation controls stress granule formation and function during erythropoiesis
RNA methylation controls stress granule formation and function during erythropoiesis Open
Stress granules (SGs) are crucial in RNA regulation, affecting cell fate and function. SGs contain RNAs, some of which can be methylated. We studied m 6 A RNA modifications during the human CD34 + HSPCs (hCD34 + ) differentiating into eryt…
ADAT2/3-mediated tRNA editing promotes cancer cell growth and tumorigenicity Open
Transfer RNAs (tRNAs) are subject to various chemical modifications that influence their stability or function. Adenosine to Inosine (A-to-I) editing in the tRNA anticodon at position A34 is an important modification that expands anticodon…
Mapping multiple RNA modifications simultaneously by proximity barcode sequencing Open
RNA is subject to a multitude of different chemical modifications that collectively represent the epitranscriptome. Individual RNA modifications including N6-methyladenosine (m 6 A) on mRNA play essential roles in the posttranscriptional c…
How Cancer Cells Hijack Protein Production to Grow Quickly Open
The cells in your body contain genes made of DNA. Genes store the genetic information passed on to you by your parents. This information serves as the recipe to make proteins, and proteins build, maintain, and heal every tissue in your bod…
Ribo-uORF: a comprehensive data resource of upstream open reading frames (uORFs) based on ribosome profiling Open
Upstream open reading frames (uORFs) are typically defined as translation sites located within the 5′ untranslated region upstream of the main protein coding sequence (CDS) of messenger RNAs (mRNAs). Although uORFs are prevalent in eukaryo…
Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers Open
Mitochondrial DNA (mtDNA) is highly polymorphic and encodes 13 proteins which are critical to the production of ATP via oxidative phosphorylation. As mtDNA is maternally inherited and undergoes negligible recombination, acquired mutations …
Nucleotide resolution profiling of m3C RNA modification by HAC-seq Open
Cellular RNAs are subject to a myriad of different chemical modifications that play important roles in controlling RNA expression and function. Dysregulation of certain RNA modifications, the so-called ‘epitranscriptome’, contributes to hu…
The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function Open
The mRNA N6-methyladenosine (m6A) modification has emerged as an essential regulator of normal and malignant hematopoiesis. Inactivation of the m6A mRNA reader YTHDF2, which recognizes m6A-modified transcripts to promote m6A-mRNA degradati…
Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia Open
Calmodulin inhibitors rescue erythropoiesis and p53-dependent phenotypes of Diamond-Blackfan anemia.
TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs Open
TRIM71 is an important RNA-binding protein in development and disease, yet its direct targets have not been investigated globally. Here we describe a number of disease and developmentally-relevant TRIM71 RNA targets such as the MBNL family…
RiboToolkit: an integrated platform for analysis and annotation of ribosome profiling data to decode mRNA translation at codon resolution Open
Ribosome profiling (Ribo-seq) is a powerful technology for globally monitoring RNA translation; ranging from codon occupancy profiling, identification of actively translated open reading frames (ORFs), to the quantification of translationa…
METTL5, an 18S rRNA-specific m <sup>6</sup> A methyltransferase, modulates expression of stress response genes Open
RNA N 6 -methyladenosine (m 6 A) modification is present in different RNA molecules, including protein-coding mRNAs and non-coding RNAs such as ribosomal RNAs (rRNAs). Previous studies identified m 6 A in both the 18S and 28S rRNAs, but th…
Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing Open
In this large whole-exome sequencing study of severe statin-related muscle injury conducted to date, we did not find evidence that rare coding variants are responsible for this adverse drug reaction. Larger sample sizes would be required t…
RNAmod: an integrated system for the annotation of mRNA modifications Open
Dynamic and reversible RNA modifications such as N6-methyladenosine (m6A) can play important roles in regulating messenger RNA (mRNA) splicing, export, stability and translation. Defective mRNA modification through altered expression of th…