Richard Ivell
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View article: Insulin-like peptide 3 is not a biomarker for pancreatic ductal adenocarcinoma
Insulin-like peptide 3 is not a biomarker for pancreatic ductal adenocarcinoma Open
Pancreatic ductal carcinoma (PDAC) is a rapidly growing cancer with a very poor prognosis. It is, therefore, important to develop novel, specific biomarkers to identify such cancers as early as possible. In a recent article published in Na…
View article: Maternal, childhood and adolescent influences on Leydig cell functional capacity and circulating INSL3 concentration in young adults: Importance of childhood infections and body mass index
Maternal, childhood and adolescent influences on Leydig cell functional capacity and circulating INSL3 concentration in young adults: Importance of childhood infections and body mass index Open
Background The constitutive Leydig cell hormone insulin‐like peptide 3 (INSL3) is considered a good estimate of the adult Leydig cell functional capacity and appears to remain relatively consistent throughout adult male life, only graduall…
View article: Defining the end of puberty in boys: INSL3 and the acute determinants of adult Leydig-cell functional capacity
Defining the end of puberty in boys: INSL3 and the acute determinants of adult Leydig-cell functional capacity Open
Introduction Testicular Leydig cells are responsible for producing almost all the testosterone required by men throughout the lifespan, with reduced testosterone (hypogonadism) correlating with age-linked morbidity and mortality. Leydig ce…
View article: The proliferation of derivative and redundant studies in endocrinology due to the application of Mendelian Randomisation and other methods to open databases
The proliferation of derivative and redundant studies in endocrinology due to the application of Mendelian Randomisation and other methods to open databases Open
The proliferation of derivative and redundant studies in endocrinology due to the application of Mendelian Randomisation and other methods to open databases
View article: Oxytocin
Oxytocin Open
View article: Insulin-like peptide 3 (INSL3) as an indicator of leydig cell insufficiency (LCI) in Middle-aged and older men with hypogonadism: reference range and threshold
Insulin-like peptide 3 (INSL3) as an indicator of leydig cell insufficiency (LCI) in Middle-aged and older men with hypogonadism: reference range and threshold Open
Insulin-like peptide 3 (INSL3) is a circulating biomarker for Leydig cell functional capacity in men, also indicating Leydig Cell Insufficiency (LCI) and potential primary hypogonadism. Using results from large cohort studies we explore so…
View article: INSL3 Variation in Dogs Following Suppression and Recovery of the HPG Axis
INSL3 Variation in Dogs Following Suppression and Recovery of the HPG Axis Open
Insulin-like peptide 3 (INSL3) is a constitutive product of mature, adult-type Leydig cells of the testes and consequently in most mammals is an ideal biomarker with which to monitor pubertal development. A new heterologous time-resolved f…
View article: Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men
Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men Open
Background Delayed puberty in males is almost invariably associated with constitutional delay of growth and puberty (CDGP) or congenital hypogonadotrophic hypogonadism (CHH). Establishing the cause at presentation is challenging, with “red…
View article: The Leydig cell biomarker INSL3 as a predictor of age-related morbidity: Findings from the EMAS cohort
The Leydig cell biomarker INSL3 as a predictor of age-related morbidity: Findings from the EMAS cohort Open
Background Insulin-like peptide 3 (INSL3) is a constitutive hormone secreted in men by the mature Leydig cells of the testes. It is an accurate biomarker for Leydig cell functional capacity, reflecting their total cell number and different…
View article: Influence on the adult male Leydig cell biomarker insulin‐like peptide 3 of maternal exposure to estrogenic and anti‐androgenic endocrine disrupting compound mixtures: A retrospective study
Influence on the adult male Leydig cell biomarker insulin‐like peptide 3 of maternal exposure to estrogenic and anti‐androgenic endocrine disrupting compound mixtures: A retrospective study Open
Insulin-like peptide 3 (INSL3) is a peptide biomarker secreted specifically by the mature Leydig cells of the testes. It is constitutive, has low within-individual variance, and effectively measures the functional capacity of Leydig cells …
View article: Association of age, hormonal, and lifestyle factors with the Leydig cell biomarker INSL3 in aging men from the European Male Aging Study cohort
Association of age, hormonal, and lifestyle factors with the Leydig cell biomarker INSL3 in aging men from the European Male Aging Study cohort Open
Background Aging in men is accompanied by a broad range of symptoms, including sexual dysfunction, cognitive and musculoskeletal decline, obesity, type 2 diabetes, cardiovascular disease and hypertension, organ degeneration/failure, and in…
View article: Expression and Role of INSL3 in the Fetal Testis
Expression and Role of INSL3 in the Fetal Testis Open
Insulin-like peptide 3 (INSL3) is a small peptide hormone of the insulin-relaxin family which is produced and secreted by the fetal Leydig cells in the testes only. It appears to be undetectable in female fetuses. In the human fetus INSL3 …
View article: Maternal Exposure to Dibutyl Phthalate (DBP) or Diethylstilbestrol (DES) Leads to Long-Term Changes in Hypothalamic Gene Expression and Sexual Behavior
Maternal Exposure to Dibutyl Phthalate (DBP) or Diethylstilbestrol (DES) Leads to Long-Term Changes in Hypothalamic Gene Expression and Sexual Behavior Open
Xenobiotic exposure during pregnancy and lactation has been linked to perinatal changes in male reproductive outcomes and other endocrine parameters. This pilot study wished to assess whether brief maternal exposure of rats to xenobiotics …
View article: The Physiology of Reproduction – Quo vadis?
The Physiology of Reproduction – Quo vadis? Open
The reproductive system in males and females reflects a highly dynamic underlying physiology. Yet our current understanding of this system is still largely based upon relatively simplistic snapshots of individual component cells and tissue…
View article: Male seminal parameters are not associated with Leydig cell functional capacity in men
Male seminal parameters are not associated with Leydig cell functional capacity in men Open
Background Insulin‐like peptide 3 (INSL3) is a constitutive, secreted peptide produced in the male uniquely by the Leydig cells of the testes. It is a biomarker for Leydig cell functional capacity, which is a measure of the numbers and dif…
View article: Physiology and evolution of the INSL3/RXFP2 hormone/receptor system in higher vertebrates
Physiology and evolution of the INSL3/RXFP2 hormone/receptor system in higher vertebrates Open
View article: Thresholds and Endocrine Disruptors: An Endocrine Society Policy Perspective
Thresholds and Endocrine Disruptors: An Endocrine Society Policy Perspective Open
The concept of a threshold of adversity in toxicology is neither provable nor disprovable. As such, it is not a scientific question but a theoretical one. Yet, the belief in thresholds has led to traditional ways of interpreting data deriv…
View article: Effects of acute hCG stimulation on serum INSL3 and 25‐OH vitamin D in Klinefelter syndrome
Effects of acute hCG stimulation on serum INSL3 and 25‐OH vitamin D in Klinefelter syndrome Open
Background It has recently been suggested that the hypergonadotropic hypogonadism characterizing Klinefelter syndrome (KS) might not be due to a steroidogenic dysfunction per se, but mainly to an altered testosterone (T) secretion into the…
Prepubertal nutrition alters Leydig cell functional capacity and timing of puberty Open
View article: Luteal peptides and their genes as important markers of ovarian differentiation
Luteal peptides and their genes as important markers of ovarian differentiation Open
Secreted peptide hormones and components of the steroidogenic machinery are molecules that are expressed usually in high amounts and in a time- and cell-specific fashion within the cells that give rise to the bovine corpus luteum. They thu…
View article: Insulin-like peptide 3 (INSL3) is a major regulator of female reproductive physiology
Insulin-like peptide 3 (INSL3) is a major regulator of female reproductive physiology Open
The INSL3-RXFP2 system represents a new regulatory pathway essential for the proper functioning of growing antral follicles. We still know very little about its involvement in pathologies such as PCOS or POF, and its role as a new biomarke…
View article: Perspective: A Neuro-Hormonal Systems Approach to Understanding the Complexity of Cryptorchidism Susceptibility
Perspective: A Neuro-Hormonal Systems Approach to Understanding the Complexity of Cryptorchidism Susceptibility Open
Nonsyndromic cryptorchidism is a common multifactorial, condition with long-term risks of subfertility and testicular cancer. Revealing the causes of cryptorchidism will likely improve prediction and prevention of adverse outcomes. Herein …
View article: Insulin-Like Peptide 3 (INSL3)
Insulin-Like Peptide 3 (INSL3) Open
View article: Amniotic Fluid INSL3 Measured During the Critical Time Window in Human Pregnancy Relates to Cryptorchidism, Hypospadias, and Phthalate Load: A Large Case–Control Study
Amniotic Fluid INSL3 Measured During the Critical Time Window in Human Pregnancy Relates to Cryptorchidism, Hypospadias, and Phthalate Load: A Large Case–Control Study Open
The period of the first to second trimester transition in human pregnancy represents a sensitive window for fetal organogenesis, particularly in regard to the development of the male reproductive system. This is a time of relative analytic…
View article: Testicular Function and Bone in Young Men with Severe Childhood-Onset Obesity
Testicular Function and Bone in Young Men with Severe Childhood-Onset Obesity Open
Background: Previous studies suggest increased risk for hypoandrogenism and fractures in men with obesity. We aimed to describe the effects of severe childhood-onset obesity on the cross talk between metabolic state, testes, …
View article: Supplementary Material for: Testicular Function and Bone in Young Men with Severe Childhood-Onset Obesity
Supplementary Material for: Testicular Function and Bone in Young Men with Severe Childhood-Onset Obesity Open
Background: Previous studies suggest increased risk for hypoandrogenism and fractures in men with obesity. We aimed to describe the effects of severe childhood-onset obesity on the cross talk between metabolic state, testes, …
View article: Theca Cell INSL3 and Steroids Together Orchestrate the Growing Bovine Antral Follicle
Theca Cell INSL3 and Steroids Together Orchestrate the Growing Bovine Antral Follicle Open
Insulin-like peptide 3 (INSL3) and its specific receptor RXFP2 are both expressed by theca interna cells of the growing antral follicle where they form an essential regulatory element in the production of the steroid precursor androstenedi…
View article: Oxytocin
Oxytocin Open
View article: Neohormones in milk
Neohormones in milk Open
View article: Male Seminal Relaxin Contributes to Induction of the Post-mating Cytokine Response in the Female Mouse Uterus
Male Seminal Relaxin Contributes to Induction of the Post-mating Cytokine Response in the Female Mouse Uterus Open
The hormone relaxin is important in female reproduction for embryo implantation, cardiovascular function, and during labor and lactation. Relaxin is also synthesized in males by organs of the male tract. We hypothesized that relaxin might …