Richard J. Blanch
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View article: Current and prospective roles of magnetic resonance imaging in mild traumatic brain injury
Current and prospective roles of magnetic resonance imaging in mild traumatic brain injury Open
There is unmet clinical need for biomarkers to predict recovery or the development of long-term sequelae of mild traumatic brain injury, a highly prevalent condition causing a constellation of disabling symptoms. A substantial proportion o…
View article: Early versus delayed timing of vitrectomy after open-globe injury
Early versus delayed timing of vitrectomy after open-globe injury Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of early versus delayed timing of vitrectomy after open-globe injury on visual outcomes.
View article: Early versus Delayed Timing of Primary Repair after Open-Globe Injury
Early versus Delayed Timing of Primary Repair after Open-Globe Injury Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Understanding how traumatic brain injury-related changes in fluid biomarkers affect quality of life outcomes in veterans: a prospective observational trial protocol (UNTANGLE)
Understanding how traumatic brain injury-related changes in fluid biomarkers affect quality of life outcomes in veterans: a prospective observational trial protocol (UNTANGLE) Open
Introduction Traumatic brain injury (TBI) is a major cause of disability, with annual global incidence estimated as 69 million people. Survivors can experience long-term visual changes, altered mental state, neurological deficits and long-…
View article: Traumatic optic neuropathy management: a systematic review
Traumatic optic neuropathy management: a systematic review Open
Background Traumatic optic neuropathy is classically described in up to 8% of patients with traumatic brain injury (TBI), but subclinical or undiagnosed optic nerve damage is much more common. When more sensitive testing is performed, at l…
View article: Improving corneal permeability of dexamethasone using penetration enhancing agents: First step towards achieving topical drug delivery to the retina
Improving corneal permeability of dexamethasone using penetration enhancing agents: First step towards achieving topical drug delivery to the retina Open
With an ever-increasing burden of vision loss caused by diseases of the posterior ocular segment, there is an unmet clinical need for non-invasive treatment strategies. Topical drug application using eye drops suffers from low to negligibl…
View article: Geographical Differences in Ophthalmic Trauma Outcomes and Risk Factors: The International Globe and Adnexal Trauma Epidemiological Eye Study (IGATES)
Geographical Differences in Ophthalmic Trauma Outcomes and Risk Factors: The International Globe and Adnexal Trauma Epidemiological Eye Study (IGATES) Open
Objectives: characterize the international variation in ophthalmic trauma and validate prognostic markers for low-, middle- and high income countries. Subjects/Methods:.Observational Multicentre cohort study using International Globe and A…
View article: Optical coherence tomography angiography analysis methods: a systematic review and meta-analysis
Optical coherence tomography angiography analysis methods: a systematic review and meta-analysis Open
Optical coherence tomography angiography (OCTA) is widely used for non-invasive retinal vascular imaging, but the OCTA methods used to assess retinal perfusion vary. We evaluated the different methods used to assess retinal perfusion betwe…
View article: Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic
Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic Open
Traumatic brain injury (TBI), a major cause of morbidity and mortality worldwide, is hard to diagnose at the point of care with patients often exhibiting no clinical symptoms. There is an urgent need for rapid point-of-care diagnostics to …
View article: Cataracts after Ophthalmic and Nonophthalmic Trauma Exposure in Service Members, U.S. Armed Forces
Cataracts after Ophthalmic and Nonophthalmic Trauma Exposure in Service Members, U.S. Armed Forces Open
ABSTRACT Introduction We aimed to identify injury-related risk factors for secondary cataract incidence after eye and brain injury and polytrauma. We also examined the effect of direct and indirect eye injury management on cataract diagnos…
View article: Contact lens-related complications in austere conditions among military personnel: a systematic review
Contact lens-related complications in austere conditions among military personnel: a systematic review Open
Introduction Military service personnel are required to deploy to austere environments where they are exposed to harsh conditions. Many service personnel continue to wear contact lenses when deployed as they are an effective alternative to…
View article: Reliability of Optical Coherence Tomography Angiography Retinal Blood Flow Analyses
Reliability of Optical Coherence Tomography Angiography Retinal Blood Flow Analyses Open
Agreement between different OCTA analyses is variable and not interchangeable. The high agreement between non-skeletonized vessel density metrics suggests that these should be routinely reported.
View article: A versatile laser-induced porcine model of outer retinal and choroidal degeneration for preclinical testing
A versatile laser-induced porcine model of outer retinal and choroidal degeneration for preclinical testing Open
Over 30 million people worldwide suffer from untreatable vision loss and blindness associated with childhood-onset and age-related eye diseases caused by photoreceptor (PR), retinal pigment epithelium (RPE), and choriocapillaris (CC) degen…
View article: Modifications in Macular Perfusion and Neuronal Loss After Acute Traumatic Brain Injury
Modifications in Macular Perfusion and Neuronal Loss After Acute Traumatic Brain Injury Open
In cases of reduced visual function after TBI, macular perfusion remained normal until reductions in GCL thickness occurred, indicating that perfusion changes were secondary to local GCL loss.
View article: Review: Emerging Eye-Based Diagnostic Technologies for Traumatic Brain Injury.
Review: Emerging Eye-Based Diagnostic Technologies for Traumatic Brain Injury. Open
The study of ocular manifestations of neurodegenerative disorders, Oculomics, is a growing field of investigation for early diagnostics, enabling structural and chemical biomarkers to be monitored overtime to predict prognosis. Traumatic b…
View article: Optical coherence tomography angiography as a surrogate marker for end-organ resuscitation in sepsis: A review
Optical coherence tomography angiography as a surrogate marker for end-organ resuscitation in sepsis: A review Open
Sepsis is a severe illness which results in alterations in the end organ microvascular haemodynamics and is associated with a high risk of mortality. There is currently no real-time method of monitoring microcirculatory perfusion during se…
View article: Global Current Practice Patterns for the Management of Hyphema
Global Current Practice Patterns for the Management of Hyphema Open
Unanimity of international institutions on hyphema management is lacking. As it stands, many current interventions have unconvincing evidence supporting their use. Evidence-based guidelines would be beneficial in guiding decision-making on…
View article: Globe and Adnexal Trauma Terminology Survey
Globe and Adnexal Trauma Terminology Survey Open
Importance Ocular trauma terminology should be periodically updated to enable comprehensive capturing and monitoring of ocular trauma in clinical and research settings. Objective To update terminology for globe and adnexal trauma. Design, …
View article: Review: Emerging Eye-Based Diagnostic Technologies for Traumatic Brain Injury
Review: Emerging Eye-Based Diagnostic Technologies for Traumatic Brain Injury Open
The study of ocular manifestations of neurodegenerative disorders, Oculomics, is a growing field of investigation for early diagnostics, enabling structural and chemical biomarkers to be monitored overtime to predict prognosis. Traumatic b…
View article: Global Current Practice Patterns for the Management of Exogenous Endophthalmitis: A Survey by the American Society of Ophthalmic Trauma
Global Current Practice Patterns for the Management of Exogenous Endophthalmitis: A Survey by the American Society of Ophthalmic Trauma Open
To investigate the global practice patterns for the management of exogenous endophthalmitis. This cross-sectional study was conducted to assess global practice patterns for the management of exogenous endophthalmitis. An online survey comp…