Richard J. Lewis
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View article: A General Food Chain Model for Bioaccumulation of Ciguatoxin into Herbivorous Fish in the Pacific Ocean Suggests Few Gambierdiscus Species Can Produce Poisonous Herbivores, and Even Fewer Can Produce Poisonous Higher Trophic Level Fish
A General Food Chain Model for Bioaccumulation of Ciguatoxin into Herbivorous Fish in the Pacific Ocean Suggests Few Gambierdiscus Species Can Produce Poisonous Herbivores, and Even Fewer Can Produce Poisonous Higher Trophic Level Fish Open
We adapt previous conceptual and numerical models of ciguateric food chains for the bioaccumulation of Pacific-ciguatoxin-1 (P-CTX-1) to a general model for bioaccumulation of P-CTX3C by parrotfish (Scarus frenatus, S. niger, and S. psitta…
View article: Profiling the Paralytic Effects and Lethality of Cone Snail Venom Toxins Using Nanofractionation Analytics with In Vivo Zebrafish Larvae Assays
Profiling the Paralytic Effects and Lethality of Cone Snail Venom Toxins Using Nanofractionation Analytics with In Vivo Zebrafish Larvae Assays Open
This study presents nanofractionation analytics coupled with in vivo profiling of zebrafish embryo paralysis and lethality in response to toxins in cone snail venoms. The focus of this study is on the development of this approach using ven…
View article: A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response
A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response Open
Eukaryotic initiation factor 2B (eIF2B), a guanine nucleotide exchange factor (GEF), promotes protein synthesis by charging translation initiation factor 2 (eIF2) with GTP. Stress-induced phosphorylation of eIF2 on its α-subunit [eIF2(αP)]…
View article: Balancing Activity and Stability in Phenol Oxidation via In Situ H <sub>2</sub> O <sub>2</sub> Generation Over Fe‐Modified AuPd Catalysts
Balancing Activity and Stability in Phenol Oxidation via In Situ H <sub>2</sub> O <sub>2</sub> Generation Over Fe‐Modified AuPd Catalysts Open
Harnessing the in situ generation of hydrogen peroxide (H 2 O 2 ) and associated reactive oxygen species (ROS) from molecular hydrogen (H 2 ) and oxygen (O 2 ) offers a powerful and sustainable alternative to conventional oxidative treatme…
View article: Proline hydroxylation and C-terminal amidation in µ-conotoxins increase structural stability and potency at sodium channels
Proline hydroxylation and C-terminal amidation in µ-conotoxins increase structural stability and potency at sodium channels Open
Conotoxins are disulfide-rich peptides isolated from the venoms of marine cone snails. These natural products have inspired the development of several drug candidates and novel therapeutic leads. In addition to disulfide bonds, many conoto…
View article: Modelling the Bioaccumulation of Ciguatoxins in Parrotfish on the Great Barrier Reef Reveals Why Biomagnification Is Not a Property of Ciguatoxin Food Chains
Modelling the Bioaccumulation of Ciguatoxins in Parrotfish on the Great Barrier Reef Reveals Why Biomagnification Is Not a Property of Ciguatoxin Food Chains Open
We adapt previously developed conceptual and numerical models of ciguateric food chains on the Great Barrier Reef, Australia, to model the bioaccumulation of ciguatoxins (CTXs) in parrotfish, the simplest food chain with only two trophic l…
View article: High ciguatoxin-producing Gambierdiscus clade (Gonyaulacales, Dinophyceae) as a source of toxins causing ciguatera poisoning
High ciguatoxin-producing Gambierdiscus clade (Gonyaulacales, Dinophyceae) as a source of toxins causing ciguatera poisoning Open
Ciguatera Poisoning (CP) is caused by neurotoxins (Ciguatoxins, CTXs) produced by microbial eukaryotes (Gambierdiscus, Fukuyoa: Dinophyceae) that accumulate in seafood and can result in severe human illness. More than 80 % of the world's C…
View article: The impact of a mindful compassion program for medical trainees
The impact of a mindful compassion program for medical trainees Open
View article: Reviewing Evidence for Disturbance to Coral Reefs Increasing the Risk of Ciguatera
Reviewing Evidence for Disturbance to Coral Reefs Increasing the Risk of Ciguatera Open
The hypothesis that disturbance to coral reefs creates new surfaces that increase the risk of ciguatera is premised upon the increased algal substrates that develop on these surfaces being colonised by high ciguatoxin (CTX)-producing Gambi…
View article: Singapore Blue arboreal tarantula peptide Lv1a preferentially targets NaV1.6 with New World–like pharmacological mechanism
Singapore Blue arboreal tarantula peptide Lv1a preferentially targets NaV1.6 with New World–like pharmacological mechanism Open
View article: The effect of support calcination on carbon supported palladium catalysts for solvent-free benzyl alcohol oxidation
The effect of support calcination on carbon supported palladium catalysts for solvent-free benzyl alcohol oxidation Open
The pretreatment of carbon support in Pd catalysts has a marked effect on final performance in the solvent free oxidation of benzyl alcohol, due to the introduction of oxygen functionality and subsequent increased dispersion of active meta…
View article: PeptideMiner—neuropeptide discovery across the animal kingdom
PeptideMiner—neuropeptide discovery across the animal kingdom Open
Neuropeptides represent the largest and most diverse class of cell-to-cell signaling molecules, holding important roles in animal physiology and behavior. They are evolutionarily ancient and widely distributed across the animal kingdom. Al…
View article: Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3.3 and CaV3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain
Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3.3 and CaV3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain Open
Venom peptides have evolved to target a wide range of membrane proteins through diverse mechanisms of action and structures, providing promising therapeutic leads for diseases, including pain, epilepsy, and cancer, as well as unique probes…
View article: HSQC Spectra Simulation and Matching for Molecular Identification.
HSQC Spectra Simulation and Matching for Molecular Identification. Open
In the pursuit of improved compound identification and database search tasks, this study explores heteronuclear single quantum coherence (HSQC) spectra simulation and matching methodologies. HSQC spectra serve as unique molecular fingerpri…
View article: Inhibition of N-type calcium channels by phenoxyaniline and sulfonamide analogues
Inhibition of N-type calcium channels by phenoxyaniline and sulfonamide analogues Open
A detailed SAR study led to two potent Ca V 2.2 inhibitors, the sulfonamide derivatives 42 and 45, which showed high plasma stability, low toxicity, favourable CNS MPO scores (4.0–4.4), and strong potency.
View article: <i>N</i>-Sulfonylphenoxazines as neuronal calcium ion channel blockers
<i>N</i>-Sulfonylphenoxazines as neuronal calcium ion channel blockers Open
A series of N -sulfonylphenoxazines were synthesised and tested for Ca V 2.2 and Ca V 3.2 ion channel inhibition. Compounds with low micromolar activity for Ca V 2.2 had good plasma stability and liver microsomal stability, and favourable …
View article: Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes
Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes Open
The structure-function and optimization studies of Na V -inhibiting spider toxins have focused on developing selective inhibitors for peripheral pain-sensing Na V 1.7. With several Na V subtypes emerging as potential therapeutic targets, s…
View article: Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples
Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples Open
The κ-opioid receptor (KOR) is an attractive target for the development of novel drugs. KOR agonists are potentially safer pain medications, whereas KOR antagonists are promising drug candidates for the treatment of neuropsychiatric disord…
View article: Ciguatera Fish Poisoning in the Caribbean Sea and Atlantic Ocean: Reconciling the Multiplicity of Ciguatoxins and Analytical Chemistry Approach for Public Health Safety
Ciguatera Fish Poisoning in the Caribbean Sea and Atlantic Ocean: Reconciling the Multiplicity of Ciguatoxins and Analytical Chemistry Approach for Public Health Safety Open
Ciguatera is a major circumtropical poisoning caused by the consumption of marine fish and invertebrates contaminated with ciguatoxins (CTXs): neurotoxins produced by endemic and benthic dinoflagellates which are biotransformed in the fish…
View article: Coordinated adaptations define the ontogenetic shift from worm- to fish-hunting in a venomous cone snail
Coordinated adaptations define the ontogenetic shift from worm- to fish-hunting in a venomous cone snail Open
View article: 165 A review of medical therapy for heart failure in patients receiving crt devices between 2011-2022
165 A review of medical therapy for heart failure in patients receiving crt devices between 2011-2022 Open
Background It is well understood that Cardiac Resynchronisation therapy (CRT) can be beneficial for some heart failure patients who remain symptomatic despite optimal medical therapy. Significant advancements have been made in recent years…
View article: Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors
Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors Open
αD-conotoxins are 11 kDa homodimers that potently inhibit nicotinic acetylcholine receptors (nAChRs) through a non-competitive (allosteric) mechanism. In this study, we describe the allosteric binding mode of the granulin-like C-terminal (…
View article: Model of the Origin of a Ciguatoxic Grouper (Plectropomus leopardus)
Model of the Origin of a Ciguatoxic Grouper (Plectropomus leopardus) Open
Published data were used to model the transfer of ciguatoxins (CTX) across three trophic levels of a marine food chain on the Great Barrier Reef (GBR), Australia, to produce a mildly toxic common coral trout (Plectropomus leopardus), one o…
View article: Correction to “Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1–Nrf2 Protein–Protein Interaction”
Correction to “Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1–Nrf2 Protein–Protein Interaction” Open
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1–Nrf2 Prote…
View article: Prognostic Factors to Reduce ICU Overtriage in Elderly Patients with Isolated Mild Traumatic Brain Injury
Prognostic Factors to Reduce ICU Overtriage in Elderly Patients with Isolated Mild Traumatic Brain Injury Open
Introduction: Elderly patients with mild traumatic brain injury (mTBI) are frequently admitted to an intensive care unit (ICU), which is potentially both harmful and unnecessary. It is not known which patients may be safely observed in a n…
View article: Bimodal Cell Size and Fusing Cells Observed in a Clonal Culture of the Ciguatoxin-Producing Benthic Dinoflagellate Gambierdiscus (WC1/1)
Bimodal Cell Size and Fusing Cells Observed in a Clonal Culture of the Ciguatoxin-Producing Benthic Dinoflagellate Gambierdiscus (WC1/1) Open
Cells in a clonal culture of the WC1/1 strain of Gambierdiscus that produced ciguatoxin and maitotoxin-3 were observed to spontaneously fuse during the light phase of culture growth. Cells in the process of fusion were indistinguishable fr…
View article: The Deadly Toxin Arsenal of the Tree-Dwelling Australian Funnel-Web Spiders
The Deadly Toxin Arsenal of the Tree-Dwelling Australian Funnel-Web Spiders Open
Australian funnel-web spiders are amongst the most dangerous venomous animals. Their venoms induce potentially deadly symptoms, including hyper- and hypotension, tachycardia, bradycardia and pulmonary oedema. Human envenomation is more fre…
View article: The T-type calcium channel CaV3.2 regulates bladder afferent responses to mechanical stimuli
The T-type calcium channel CaV3.2 regulates bladder afferent responses to mechanical stimuli Open
The bladder wall is innervated by a complex network of afferent nerves that detect bladder stretch during filling. Sensory signals, generated in response to distension, are relayed to the spinal cord and brain to evoke physiological and pa…
View article: Coordinated adaptations define the ontogenetic shift from worm- to fish-hunting in a venomous cone snail
Coordinated adaptations define the ontogenetic shift from worm- to fish-hunting in a venomous cone snail Open
Marine cone snails have attracted researchers from all disciplines but early life stages have received limited attention due to difficulties accessing or rearing juvenile specimens. Here, we document for the first time the culture ofConus …
View article: Origin of Ciguateric Fish: Quantitative Modelling of the Flow of Ciguatoxin through a Marine Food Chain
Origin of Ciguateric Fish: Quantitative Modelling of the Flow of Ciguatoxin through a Marine Food Chain Open
To begin to understand the impact of food chain dynamics on ciguatera risk, we used published data to model the transfer of ciguatoxins across four trophic levels of a marine food chain in Platypus Bay, Australia. The data to support this …