Explanipedia

Assessment of protocols for characterization of the human skin microbiome using shotgun metagenomics and comparative analysis with 16S metabarcoding Open

Florian Plaza Oñate, Benoît Quinquis, Florence Thirion, Marine Gilles, Christian Morabito , et al. · 2025

The skin microbiome includes bacteria, fungi, and viruses, with composition varying significantly across body sites. Although 16S rRNA gene sequencing is common, it excludes non-prokaryotic taxa and offers limited functional data. Shotgun …

An ontological analysis of a dataset of curated dermatological gene disease associations (G2P-Skin) Open

Tania A Agathangelidi, Luke Carson, Brent J. Doolan, Anna Dubois, Richard J. Martin , et al. · 2025

More than 607 genodermatoses have been associated with pathogenic variants in 477 genes, which are captured in the updated Genotype 2 Phenotype (G2P) Skin dataset. Here we report: 1) the utility of this clinically curated database for the …

Detection of urothelial carcinoma in Lynch syndrome using microsatellite instability analysis of urine cell-free DNA Open

R. E. Hall, Richard Gallon, Christine Hayes, Patricia Herrero-Belmonte, Rachel Phelps , et al. · 2025

Positive allosteric modulation of emodepside sensitive Brugia malayi SLO-1F and Onchocerca volvulus SLO-1A potassium channels by GoSlo-SR-5-69 Open

Mark McHugh, Charity N. Njeshi, Nathaniel Smith, Sudhanva S. Kashyap, Real Datta , et al. · 2025

Human lymphatic filariasis and onchocerciasis are Neglected Tropical Diseases (NTDs), of major public health concern. Prophylaxis and treatment rely on anthelmintics that effectively eliminate migrating microfilariae but lack efficacy agai…

Diethylcarbamazine elicits calcium signals by activation of Brugia malayi TRP-2b channels heterologously expressed in HEK293 cells Open

Paul Williams, Sudhanva S. Kashyap, Alan P. Robertson, Richard J. Martin · 2025

Effects of Emodepside on Single-Channel Properties of Onchocerca volvulus SLO-1A (BK) Potassium Channels Open

Charity N. Njeshi, Shivani Choudhary, Mark McHugh, Sudhanva Srinivas Kash, Alan P. Robertson , et al. · 2025

Evaluation of whole-body MRI for cancer early detection in Li-Fraumeni syndrome Open

Peter Sodde, Zerin Hyder, Sarah Pugh, Fiona Lalloo, Richard J. Martin , et al. · 2025

Li-Fraumeni syndrome (LFS) is a high-risk hereditary cancer predisposition syndrome affecting 1 in 5000 individuals. Current standard of care in adults includes annual whole-body MRI (WB-MRI) and MRI brain (MRB) surveillance to enable earl…

Positive allosteric modulation of emodepside sensitive Brugia malayi SLO-1F and Onchocerca volvulus SLO-1A potassium channels by GoSlo-SR-5-69 Open

Mark McHugh, Charity N. Njeshi, Nathaniel Smith, Sudhanva S. Kashyap, Real Datta , et al. · 2025

Human lymphatic filariasis and onchocerciasis are Neglected Tropical Diseases (NTDs), of major public health concern. Prophylaxis and treatment rely on anthelmintics that effectively eliminate migrating microfilariae but lack efficacy agai…

Detection of Urothelial Carcinoma in Lynch Syndrome Using a Novel Microsatellite Instability Assay on Postal Urine Samples Open

Rebecca J Hall, Richard Gallon, Christine Hayes, Patricia Herrero-Belmonte, Rachel Phelps , et al. · 2025

Emodepside: the anthelmintic’s mode of action and toxicity Open

Charity N. Njeshi, Alan P. Robertson, Richard J. Martin · 2024

Nematode parasitic infections continue to be a major health problem for humans and animals. Drug resistance to currently available treatments only worsen the problem. Drug discovery is expensive and time-consuming, making drug repurposing …

The nematode (Ascaris suum) intestine is a location of synergistic anthelmintic effects of Cry5B and levamisole Open

Paul Williams, Matthew T. Brewer, Raffi V. Aroian, Alan P. Robertson, Richard J. Martin · 2024

A novel group of biocidal compounds are the Crystal 3D (Cry) and Cytolytic (Cyt) proteins produced by Bacillus thuringiensis (Bt). Some Bt Cry proteins have a selective nematocidal activity, with Cry5B being the most studied. Cry5B kills n…

Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids Open

Adrian J. Wolstenholme, Erik C. Andersen, Shivani Choudhary, Friederike Ebner, Susanne Hartmann , et al. · 2024

The nematode (Ascaris suum) intestine is a location of synergistic anthelmintic effects of Cry5B and levamisole Open

Paul Williams, Matthew T. Brewer, Raffi V. Aroian, Alan P. Robertson, Richard J. Martin · 2023

A novel group of biocidal compounds are the Crystal 3D (Cry) and Cytolytic (Cyt) proteins produced by Bacillus thuringiensis (Bt). Some Bt Cry proteins have a selective nematocidal activity, with Cry5B being the most studied. Cry5B kills n…

Diethylcarbamazine elicits Ca 2+ signals through TRP-2 channels that are potentiated by emodepside in Brugia malayi muscles Open

Paul Williams, Sudhanva S. Kashyap, Alan P. Robertson, Richard J. Martin · 2023

Filarial nematode infections are a major health concern in several countries. Lymphatic filariasis is caused by Wuchereria bancrofti and Brugia spp. affecting over 120 million people. Heavy infections can lead to elephantiasis, which has s…

Anthelmintics V: Drugs, resistance, and vaccines Open

Raffi V. Aroian, Alex Loukas, Richard J. Martin · 2023

Diethylcarbamazine elicits Ca2+signals through TRP-2 channels that are potentiated by emodepside inBrugia malayimuscles Open

Paul Williams, Sudhanva S. Kashyap, Alan P. Robertson, Richard J. Martin · 2023

Filarial nematode infections are a major health concern in several countries. Lymphatic filariasis is caused by Wucheria bancrofti and Brugia spp. affecting over 120 million people. Heavy infections can lead to elephantiasis having serious…

Supplementary Figures and Tables from Distinctive Subpopulations of Stromal Cells Are Present in Human Lymph Nodes Infiltrated with Melanoma Open

Jennifer Eom, Saem Mul Park, Vaughan Feisst, Chun‐Jen J. Chen, Joanna E. Mathy , et al. · 2023

Supplementary Figures 1-6 and Tables 1-7

Supplementary Figures and Tables from Distinctive Subpopulations of Stromal Cells Are Present in Human Lymph Nodes Infiltrated with Melanoma Open

Jennifer Eom, Saem Mul Park, Vaughan Feisst, Chun‐Jen J. Chen, Joanna E. Mathy , et al. · 2023

Supplementary Figures 1-6 and Tables 1-7

Unusual Relapse of Low Hypodiploid Acute Lymphoblastic Leukaemia in a Family with Li-Fraumeni Syndrome Open

Frederik W. van Delft, Simon Bailey, Kate Pearce, Richard J. Martin, Roderick Skinner , et al. · 2023

This brief report describes the importance of close discussion between clinicians and scientists and progress in leukaemia genetic work-up to deliver optimal treatment to a girl with 2 episodes of childhood Acute Lymphoblastic Leukaemia. A…

Model Penilaian Strategi Pertahanan Matra Laut Negara Kepulauan Berbasis System Dynamic Open

Richard J. Martin, Amin Setyo Laksono, Harsuko Riniwati, Setyo Widagdo · 2023

The maritime dimension defense strategy model is a part of the Archipelago Marine Defense Strategy, referring to the dynamics or developments in the strategic environment and the capabilities of available national resources. In carrying ou…

Diethylcarbamazine, TRP channels and Ca2+ signaling in cells of the Ascaris intestine Open

Paul Williams, Sudhanva S. Kashyap, Mark McHugh, Matthew T. Brewer, Alan P. Robertson , et al. · 2022

Issue Information Open

Sangeetha Sethuraman, Karl Franz, L Pye, Rui M. Almeida, Aldo R. Boccaccini , et al. · 2022

Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…

Diethylcarbamazine mediated potentiation of emodepside induced paralysis requires TRP-2 in adult Brugia malayi Open

Sudhanva S. Kashyap, Mark McHugh, Alan P. Robertson, Richard J. Martin · 2022

Nodulisporic acid produces direct activation and positive allosteric modulation of AVR-14B, a glutamate-gated chloride channel from adult Brugia malayi Open

Shivani Choudhary, Melanie Abongwa, Sudhanva S. Kashyap, Saurabh Verma, Gunnar R. Mair , et al. · 2022

Glutamate-gated chloride channels (GluCls) are unique to invertebrates and are targeted by macrocyclic lactones. In this study, we cloned an AVR-14B GluCl subunit from adult Brugia malayi , a causative agent of lymphatic filariasis in huma…

Therapeutic and Diagnostic Innovation for Parasitology: Grand Challenges Open

Richard J. Martin · 2022

SPECIALTY GRAND CHALLENGE article Front. Parasitol., 04 July 2022Sec. Therapeutics and Diagnostics https://doi.org/10.3389/fpara.2022.963671

High concentrations of the anthelmintic diethylcarbamazine paralyze C. elegans independently of TRP-2 Open

Real Datta, Alan P. Robertson, Richard J. Martin, Sudhanva S. Kashyap · 2022

Diethylcarbamazine (DEC) is a classic anthelmintic used to treat diseases caused by filarial nematodes like lymphatic filariasis and loiasis. DEC is very effective in clearing the microfilaria from the blood, but the therapeutic effects ar…

Omega- 3 Fatty Acids and Major Depression: A Mendelian Randomization Study Open

Rebecca Carnegie, Hannah Jones, Maria Carolina Borges, Phillip Haycock, Jie Zheng , et al. · 2022

Objective: Omega-3 fatty acids have been implicated in the aetiology of depressive disorders, though trials supplementing omega 3 to prevent depression have so far been unsuccessful. Whether this association is causal remains unclear. Meth…

A11 ISOLATION OF NON-POLAR METABOLITES IN EXCRETORY/SECRETORY PRODUCTS FROM PARASITIC HELMINTHS AND THEIR POTENTIAL AS IMMUNOTHERAPY IN INFLAMMATORY BOWEL DISEASE Open

E A Siciliani, Louis‐Philippe Leroux, M Tam, Toshio Arai, Joseph F. Urban , et al. · 2022

Background Parasitic helminths are known to modulate host immune responses. This is thought to be mediated by their secretome. We are interested in the excretory/secretory products and mechanisms for modulating immune dysfunction in autoin…

Diethylcarbamazine, TRP channels and Ca2+ signaling in cells of the Ascaris intestine Open

Paul Williams, Sudhanva S. Kashyap, Mark McHugh, Alan P. Robertson, Richard J. Martin · 2022

The nematode parasite intestine absorbs nutrients, is involved in innate immunity, can metabolize xenobiotics and as we show here, is also a site of action of the anthelmintic, diethylcarbamazine. Diethylcarbamazine (DEC) is used to treat …

Changes in Gut Microbiota of Patients with Atopic Dermatitis During Balneotherapy Open

Florence Thirion, Susie Guilly, Sébastien Fromentin, Florian Plaza Oñate, Anne‐Sophie Alvarez , et al. · 2022

Florence Thirion,1,* Susie Guilly,1,* Sébastien Fromentin,1 Florian Plaza Oñate,1 Anne-Sophie Alvarez,1 Emmanuelle Le Chatelier,1 Nicolas Pons,1 Florence Levenez,1 Benoît Quinquis,1 Stanislav Ehrlich,1 Joel Doré,1,2 Richard Martin,3 Sophie…

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