Richard Küehl
YOU?
Author Swipe
View article: Unbiased DNA Pathogen Detection in Tissues: Real-World Experience With Metagenomic Sequencing in Pathology
Unbiased DNA Pathogen Detection in Tissues: Real-World Experience With Metagenomic Sequencing in Pathology Open
Pathogen detection in formalin-fixed paraffin-embedded (FFPE) tissue remains challenging. We implemented metagenomic next-generation sequencing (mNGS) in our clinical diagnostic workflow to evaluate its feasibility, diagnostic yield, and p…
View article: Microgeography of staphyloccoci in human tissue explains antibiotic failure
Microgeography of staphyloccoci in human tissue explains antibiotic failure Open
Summary paragraph Bacterial infections remain a major health threat, yet pathogen biology in human tissues is poorly understood. Using AI-guided imaging, we mapped ∼15,500 Staphylococcus aureus cells in biopsies from 33 patients undergoing…
View article: Current Concepts in Shoulder Periprosthetic Joint Infections—Are Shoulders the Same as Hips and Knees?
Current Concepts in Shoulder Periprosthetic Joint Infections—Are Shoulders the Same as Hips and Knees? Open
Background/Objectives: The vast amount of research and data on periprosthetic joint infection (PJI) is focussed on infections in hip and knee replacements. This article aims to highlight the special features of PJI in shoulders. Methods: T…
View article: Amoxicillin Concentrations in Samples of Musculoskeletal Infections
Amoxicillin Concentrations in Samples of Musculoskeletal Infections Open
Amoxicillin is a frequently used beta‐lactam antibiotic and at the same time a fragile analyte. Aim of this work was to investigate the sensitive properties of amoxicillin in biological samples and validate a quantification method for amox…
View article: Fracture-related infections of the lower extremity – Analysis of costs and their drivers
Fracture-related infections of the lower extremity – Analysis of costs and their drivers Open
This study illustrates the financial burden of FRI in a DRG system and identifies potential drivers for these costs. Since repeated surgeries or unplanned surgical revisions are drivers of costs, optimal pre-operative planning and coordina…
View article: The myocutaneous gastrocnemius flap for periprosthetic joint infection of the knee
The myocutaneous gastrocnemius flap for periprosthetic joint infection of the knee Open
Purpose Periprosthetic joint infection (PJI) following total knee arthroplasty (TKA) presents significant challenges, especially in elderly and comorbid patients, often necessitating revision surgeries. We report on a series of patients wi…
View article: A Far-Red Fluorescent Probe to Visualize Gram-Positive Bacteria in Patient Samples
A Far-Red Fluorescent Probe to Visualize Gram-Positive Bacteria in Patient Samples Open
Gram-positive bacteria, in particular Staphylococcus aureus (S. aureus), are the leading bacterial cause of death in high-income countries and can cause invasive infections at various body sites. These infections are associated with prolon…
View article: Key aspects of soft tissue management in fracture-related infection: recommendations from an international expert group
Key aspects of soft tissue management in fracture-related infection: recommendations from an international expert group Open
A judicious, well-planned bone and soft tissue debridement remains one of the cornerstones of state-of-the-art treatment of fracture-related infection (FRI). Meticulous surgical excision of all non-viable tissue can, however, lead to the c…
View article: A Far-Red Fluorescent Probe to Visualize<i>Staphylococcus aureus</i>in Patient Samples
A Far-Red Fluorescent Probe to Visualize<i>Staphylococcus aureus</i>in Patient Samples Open
Staphylococcus aureus (S. aureus) is the leading bacterial cause of death in high-income countries and can cause invasive infections at various body sites. These infections are associated with prolonged hospital stays, a large economic bur…
View article: A qualitative study on the perception of infection prevention and control measures among healthcare workers without patient contact during the SARS-CoV-2 pandemic
A qualitative study on the perception of infection prevention and control measures among healthcare workers without patient contact during the SARS-CoV-2 pandemic Open
We conducted a qualitative interview-based study to examine the perception of infection prevention and control (IPC) measures implemented during the COVID-19 pandemic among healthcare workers (HCWs) without patient contact in a tertiary ac…
View article: A systematic outbreak investigation of SARS-CoV-2 transmission clusters in a tertiary academic care center
A systematic outbreak investigation of SARS-CoV-2 transmission clusters in a tertiary academic care center Open
Background We sought to decipher transmission pathways in healthcare-associated infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within our hospital by epidemiological work-up and complementary whole genome sequ…
View article: Impact of adherence to individual quality-of-care indicators on the prognosis of bloodstream infection due to Staphylococcus aureus: a prospective observational multicentre cohort
Impact of adherence to individual quality-of-care indicators on the prognosis of bloodstream infection due to Staphylococcus aureus: a prospective observational multicentre cohort Open
Adherence to QCIs in S. Aureus bloodstream infection did not reach expected rates. Apart from the benefits of application as a bundle, focus control and adequate targeted therapy were independently associated with low mortality.
View article: Soft-tissue reconstruction in lower-leg fracture-related infections: An orthoplastic outcome and risk factor analysis
Soft-tissue reconstruction in lower-leg fracture-related infections: An orthoplastic outcome and risk factor analysis Open
Introduction Fracture-related infection (FRI) is a severe post-traumatic complication which is occasionally accompanied by a deficient or even avital soft-tissue envelope. In these cases, a thoroughly planned orthoplastic approach is imper…
View article: Reproductive number of the COVID-19 epidemic in Switzerland with a focus on the Cantons of Basel-Stadt and Basel-Landschaft
Reproductive number of the COVID-19 epidemic in Switzerland with a focus on the Cantons of Basel-Stadt and Basel-Landschaft Open
The World Health Organization (WHO) declared the COVID-19 outbreak a “Public Health Emergency of International Concern” on 30 January 2020, after rapid spread from a few initial cases to thousands of cases across China and introductions in…
View article: 2019-Novel Coronavirus (2019-nCoV): estimating the case fatality rate – a word of caution
2019-Novel Coronavirus (2019-nCoV): estimating the case fatality rate – a word of caution Open
It is tempting to estimate the case fatality rate by dividing the number of known deaths by the number of confirmed cases. The resulting number, however, does not represent the true case fatality rate and might be off by orders of magnitud…
View article: Diagnosing Fracture-Related Infection: Current Concepts and Recommendations
Diagnosing Fracture-Related Infection: Current Concepts and Recommendations Open
Summary:Fracture-related infection (FRI) is a severe complication after bone injury and can pose a serious diagnostic challenge. Overall, there is a limited amount of scientific evidence regarding diagnostic criteria for FRI. For this reas…
View article: Recommendations for Systemic Antimicrobial Therapy in Fracture-Related Infection: A Consensus From an International Expert Group
Recommendations for Systemic Antimicrobial Therapy in Fracture-Related Infection: A Consensus From an International Expert Group Open
Summary: Fracture-related infection (FRI) is a major complication in musculoskeletal trauma and one of the leading causes of morbidity. Standardization of general treatment strategies for FRI has been poor. One of the reasons is the hetero…
View article: Fracture-related infection
Fracture-related infection Open
Confirmatory criteria for FRI 1. Fistula, sinus or wound breakdown (with communication to the bone or the implant).
View article: Diagnosing Fracture-Related Infection: Current Concepts and Recommendations
Diagnosing Fracture-Related Infection: Current Concepts and Recommendations Open
Summary: Fracture-related infection (FRI) is a severe complication after bone injury and can pose a serious diagnostic challenge. Overall, there is a limited amount of scientific evidence regarding diagnostic criteria for FRI. For this rea…
View article: Recommendations for design and conduct of preclinical in vivo studies of orthopedic device‐related infection
Recommendations for design and conduct of preclinical in vivo studies of orthopedic device‐related infection Open
Orthopedic device‐related infection (ODRI), including both fracture‐related infection (FRI) and periprosthetic joint infection (PJI), remain among the most challenging complications in orthopedic and musculoskeletal trauma surgery. ODRI ha…
View article: Diagnostic accuracy of serum inflammatory markers in late fracture-related infection
Diagnostic accuracy of serum inflammatory markers in late fracture-related infection Open
Aims To assess the diagnostic value of C-reactive protein (CRP), leucocyte count (LC), and erythrocyte sedimentation rate (ESR) in late fracture-related infection (FRI). Materials and Methods PubMed, Embase, and Cochrane databases were sea…
View article: Culture of Bone Biopsy Specimens Overestimates Rate of Residual Osteomyelitis After Toe or Forefoot Amputation
Culture of Bone Biopsy Specimens Overestimates Rate of Residual Osteomyelitis After Toe or Forefoot Amputation Open
Background: Guidelines recommend both histological analysis and culture for definite diagnosis of osteomyelitis. It is not clear if histological and culture criteria can be used interchangeably in the clinical scenario of toe amputation. W…
View article: Accuracy of Tissue and Sonication Fluid Sampling for the Diagnosis of Fracture-Related Infection: A Systematic Review and Critical Appraisal
Accuracy of Tissue and Sonication Fluid Sampling for the Diagnosis of Fracture-Related Infection: A Systematic Review and Critical Appraisal Open
Introduction: Intraoperatively obtained peri-implant tissue cultures remain the standard for diagnosis of fracture-related infection (FRI), although culture-negative cases may complicate treatment decisions. This paper reviews the evidence…
View article: ICE volume 39 issue 7 Cover and Front matter
ICE volume 39 issue 7 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Definition of infection after fracture fixation: A systematic review of randomized controlled trials to evaluate current practice
Definition of infection after fracture fixation: A systematic review of randomized controlled trials to evaluate current practice Open
Introduction: One of the most challenging musculoskeletal complications in modern trauma surgery is infection after fracture fixation (IAFF). Although infections are clinically obvious in many cases, a clear definition of the term IAFF is …