Explanipedia

Age Bias, Missing Data, and Declining Response Rates in the National Youth Risk Behavior Survey and Their Influence on Estimates of Trends in Adolescent Sexual Experience, 2011–2023 Open

John Santelli, Richard L. Moss, Maxim Finkelstein, Laura Lindberg · 2025

Introduction The national Youth Risk Behavior Survey (YRBS) has experienced considerable declines in response rates, increases in missing data on sexual experience, and shifts in data collection – all of which raise questions about bias in…

Age Bias, Missing Data, and Declining Response Rates in the National Youth Risk Behavior Survey and Their Influence on Estimates of Trends in Adolescent Sexual Experience, 2011-2023 Open

John Santelli, Deborah E. Malden, Richard L. Moss, Maxim Finkelstein, Laura Lindberg · 2025

Introduction The national Youth Risk Behavior Survey (YRBS) has experienced considerable declines in response rates, increases in missing data on sexual experience, and shifts in data collection – all of which raise questions about bias in…

cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca2+-handling abnormalities Open

Willem J. de Lange, Emily T. Farrell, Jonathan J. Hernández, Alana Stempien, Caroline R. Kreitzer , et al. · 2023

Truncation mutations in cardiac myosin binding protein C (cMyBP-C) are common causes of hypertrophic cardiomyopathy (HCM). Heterozygous carriers present with classical HCM, while homozygous carriers present with early onset HCM that rapidl…

Further progress in understanding of myofibrillar function in health and disease Open

Christine Cremo, Richard L. Moss, Henk Granzier · 2021

The July 2021 issue of JGP is a collection of peer-reviewed articles focused on the function and dynamic regulation of contractile systems in muscle and non-muscle cells.

Cardiac MyBP-C phosphorylation regulates the Frank–Starling relationship in murine hearts Open

Laurin M. Hanft, Daniel P. Fitzsimons, Timothy A. Hacker, Richard L. Moss, Kerry S. McDonald · 2021

The Frank–Starling relationship establishes that elevated end-diastolic volume progressively increases ventricular pressure and stroke volume in healthy hearts. The relationship is modulated by a number of physiological inputs and is often…

Toward an understanding of myofibrillar function in health and disease Open

Richard L. Moss, Christine Cremo, Henk Granzier · 2021

The March 2021 issue of JGP is a collection of peer-reviewed articles focused on the function and dynamic regulation of contractile systems in muscle and non-muscle cells.

cMyBP-C phosphorylation modulates the time-dependent slowing of unloaded shortening in murine skinned myocardium Open

Jasmine Giles, Daniel P. Fitzsimons, Jitandrakumar R. Patel, Chloe Knudtsen, A. Neuville , et al. · 2021

In myocardium, phosphorylation of cardiac myosin-binding protein-C (cMyBP-C) is thought to modulate the cooperative activation of the thin filament by binding to myosin and/or actin, thereby regulating the probability of cross-bridge bindi…

Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics Open

Trisha Tucholski, Wenxuan Cai, Zachery R. Gregorich, Elizabeth F. Bayne, Stanford D. Mitchell , et al. · 2020

Significance Hypertrophic cardiomyopathy (HCM) is a common genetic heart disease and a leading cause of sudden cardiac death in young adults. HCM has been linked to mutations in genes encoding sarcomeric proteins, but how different mutatio…

The Role of cMyBP-C in Regulating the Frank-Starling Relationship Open

Laurin M. Hanft, Daniel P. Fitzsimons, Timothy A. Hacker, Richard L. Moss, Kerry S. McDonald · 2020

A case for reduced energy utilization associated with spatial disorder of myosin in skeletal muscle Open

Richard L. Moss · 2019

Moss considers recent work describing the effect of low temperature on force development in skeletal muscle.

Progress on the regulation of myofibrillar function: Part 2 Open

Henk Granzier, Richard L. Moss · 2019

The second of two special issues on contractile systems charts further progress towards an understanding of myofilament regulation.

The enduring relationship between myosin enzymatic activity and the speed of muscle contraction Open

Richard L. Moss, R. John Solaro · 2019

Moss and Solaro recall Bárány’s landmark study that identified myosin ATPase as the fundamental driver of contraction speed.

The Role of Cardiac MYBPC in Regulating Frank Starling Relationships Open

Laurin M. Hanft, Daniel P. Fitzsimons, Timothy A. Hacker, Richard L. Moss, Kerry S. McDonald · 2019

Deletion of Enigma Homologue from the Z-disc slows tension development kinetics in mouse myocardium Open

Zachery R. Gregorich, Jitandrakumar R. Patel, Wenxuan Cai, Ziqing Lin, Rachel Heurer , et al. · 2019

Enigma Homologue (ENH) is a component of the Z-disc, a structure that anchors actin filaments in the contractile unit of muscle, the sarcomere. Cardiac-specific ablation of ENH protein expression causes contractile dysfunction that ultimat…

Toward an understanding of the regulation of myofibrillar function Open

Richard L. Moss, Pieter P. de Tombe, R. John Solaro · 2018

The first of two special issues dedicated to contractile systems highlights an emerging consensus that regulatory mechanisms involve thick and thin filaments.

Recovery of left ventricular function following in vivo reexpression of cardiac myosin binding protein C Open

Jasmine Giles, Jitandrakumar R. Patel, Adam C. Miller, Elizabeth Iverson, Daniel P. Fitzsimons , et al. · 2018

The loss of cardiac myosin binding protein C (cMyBP-C) results in left ventricular dilation, cardiac hypertrophy, and impaired ventricular function in both constitutive and conditional cMyBP-C knockout (MYBPC3 null) mice. It remains unclea…

Novel Regulatory Elements within Myofilaments of Vertebrate Striated Muscles—Who Knew Open

Richard L. Moss · 2018

Organ-level right ventricular dysfunction with preserved Frank-Starling mechanism in a mouse model of pulmonary arterial hypertension Open

Zhijie Wang, Jitandrakumar R. Patel, David A. Schreier, Timothy A. Hacker, Richard L. Moss , et al. · 2018

Pulmonary arterial hypertension (PAH) is a rapidly fatal disease in which mortality is due to right ventricular (RV) failure. It is unclear whether RV dysfunction initiates at the organ level or the subcellular level or both. We hypothesiz…

Altered Right Ventricular Mechanical Properties Are Afterload Dependent in a Rodent Model of Bronchopulmonary Dysplasia Open

Jitandrakumar R. Patel, Gregory P. Barton, R. Braun, Kara N. Goss, Kristín Haraldsdóttir , et al. · 2017

Infants born premature are at increased risk for development of bronchopulmonary dysplasia (BPD), pulmonary hypertension (PH), and ultimately right ventricular (RV) dysfunction, which together carry a high risk of neonatal mortality. Howev…

Novel Sarcopenia-related Alterations in Sarcomeric Protein Post-translational Modifications (PTMs) in Skeletal Muscles Identified by Top-down Proteomics Open

Liming Wei, Zachery R. Gregorich, Ziqing Lin, Wenxuan Cai, Yutong Jin , et al. · 2017

Complete Characterization of Cardiac Myosin Heavy Chain (223 kDa) Enabled by Size-Exclusion Chromatography and Middle-Down Mass Spectrometry Open

Yutong Jin, Liming Wei, Wenxuan Cai, Ziqing Lin, Zhijie Wu , et al. · 2017

Myosin heavy chain (MHC), the major component of the myosin motor molecule, plays an essential role in force production during muscle contraction. However, a comprehensive analysis of MHC proteoforms arising from sequence variations and po…

Acting on an impulse (or two): Advantages of high-frequency tetanic onset in skeletal muscle Open

Richard L. Moss, Thomas L. Lynch, Daniel P. Fitzsimons · 2017

Moss et al. highlight why high-frequency bursts at the onset of tetany increase force development in fast-twitch skeletal muscle fibers.

Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments Open

Robert W. Kensler, Roger Craig, Richard L. Moss · 2017

Significance Cardiac myosin binding protein C (cMyBP-C) is an important regulator of myocardial contraction, but its mechanism of action is unclear. In this study, we examined the structure of thick filaments from the hearts of mice in whi…

Top-Down Targeted Proteomics Reveals Decrease in Myosin Regulatory Light-Chain Phosphorylation That Contributes to Sarcopenic Muscle Dysfunction Open

Zachery R. Gregorich, Ying Peng, Wenxuan Cai, Yutong Jin, Liming Wei , et al. · 2016

Sarcopenia, the loss of skeletal muscle mass and function with advancing age, is a significant cause of disability and loss of independence in the elderly and thus, represents a formidable challenge for the aging population. Nevertheless, …

Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase Open

Michael T. Massengill, Hassan Ashraf, Rajib Chowdhury, Stephen M. Chrzanowski, Jeena Kar , et al. · 2016

Our results, using a new mouse model mimicking an acute reduction of cMLCK, suggest that cMLCK plays a pivotal role in the transition from compensated to decompensated hypertrophy via sarcomeric disorganization.

Cardiac myosin-binding protein C: A protein once at loose ends finds its regulatory groove Open

Richard L. Moss · 2016

The cardiac isoform of myosin-binding protein C (cMyBP-C) is a sarcomeric protein that is believed to be a key regulator of myocardial contractility (review in ref. 1). Although cMyBP-C was thought for many years to be a structural scaffol…

Editorial Board Open

Merry L. Lindsey, Elizabeth Murphy, R. John Solaro, Thomas Thum, David Eisner , et al. · 2016

Editorial Board Open

Merry L. Lindsey, Elizabeth Murphy, R. John Solaro, Thomas Thum, David Eisner , et al. · 2016

Effective Top-Down LC/MS+ Method for Assessing Actin Isoforms as a Potential Cardiac Disease Marker Open

Yi‐Chen Chen, Şerife Ayaz‐Güner, Ying Peng, Nicole Lane, Matthew R. Locher , et al. · 2015

Actin is the major component of the cytoskeleton, playing an essential role in the structure and motility of both muscle and nonmuscle cells. It is highly conserved and encoded by a multigene family. α-Cardiac actin (αCAA) and α-skeletal a…

Strategies from UW-Madison for rescuing biomedical research in the US Open

Judith Kimble, William M. Bement, Qiang Chang, Benjamin L. Cox, Norman R. Drinkwater , et al. · 2015

A cross-campus, cross-career stage and cross-disciplinary series of discussions at a large public university has produced a series of recommendations for addressing the problems confronting the biomedical research community in the US.

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