Explanipedia

Understanding the development of a functional brain circuit: reward processing as an illustration Open

Maya Opendak, Heidi C. Meyer, Bridget Callaghan, Lior Abramson, Shanah Rachel John , et al. · 2025

Developmental alcohol exposure is exhausting: Sleep and the enduring consequences of alcohol exposure during development Open

Donald A. Wilson, Regina M. Sullivan, John F. Smiley, Mariko Saito, Charlis Raineki · 2024

Infant pain vs. pain with parental suppression: Immediate and enduring impact on brain, pain and affect Open

Gordon A. Barr, Maya Opendak, Rosemarie E. Perry, Emma C. Sarro, Regina M. Sullivan · 2023

Background In the short term, parental presence while a human infant is in pain buffers the immediate pain responses, although emerging evidence suggests repeated social buffering of pain may have untoward long-term effects. Methods/findin…

Homeostatic NREM sleep and salience network function in adult mice exposed to ethanol during development Open

Prachi Shah, Aayush Kaneria, Gloria Fleming, Colin R. O. Williams, Regina M. Sullivan , et al. · 2023

Developmental exposure to ethanol is a leading cause of cognitive, emotional and behavioral problems, with fetal alcohol spectrum disorder (FASD) affecting more than 1:100 children. Recently, comorbid sleep deficits have been highlighted i…

12.2 Systemic Stress Hormones and Circuit-Level Dopamine From the VTA to Amygdala BLA Cause and Maintain Early-Life Trauma-Induced Social Behavior Open

Regina M. Sullivan · 2023

Antagonistic circuits mediating infanticide and maternal care in female mice Open

Long Mei, Rongzhen Yan, Luping Yin, Regina M. Sullivan, Dayu Lin · 2023

Dynamic developmental changes in neurotransmitters supporting infant attachment learning Open

Nina Colombel, Guillaume Ferreira, Regina M. Sullivan, Gérard Coureaud · 2023

Antagonistic Neural Circuits Drive Opposing Behaviors towards the Young in Females Open

Long Mei, Rongzhen Yan, Luping Yin, Regina M. Sullivan, Dayu Lin · 2023

In many species, including mice, females show strikingly different pup-directed behaviors based on their reproductive state 1,2 . Naïve wild female mice often kill pups while lactating females are dedicated to pup caring 3,4 . The neural m…

From circuits to behavior: Amygdala dysfunction in fragile X syndrome Open

Matthew N. Svalina, Regina M. Sullivan, Diego Restrepo, Molly M. Huntsman · 2023

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a repeat expansion mutation in the promotor region of the FMR1 gene resulting in transcriptional silencing and loss of function of fragile X messenger ribonucleoprotein 1 …

Unique neurobiology during the sensitive period for attachment produces distinctive infant trauma processing Open

Maya Opendak, Regina M. Sullivan · 2023

Trauma has neurobehavioral effects when experienced at any stage of development, but trauma experienced in early life has unique neurobehavioral outcomes related to later life psychiatric sequelae. Recent evidence has further highlighted t…

Outcomes at least 90 days since onset of myocarditis after mRNA COVID-19 vaccination in adolescents and young adults in the USA: a follow-up surveillance study Open

Ian Kracalik, Matthew E. Oster, Karen R. Broder, Margaret M. Cortese, Maleeka Glover , et al. · 2022

Basolateral Amygdala Hyperexcitability Is Associated with Precocious Developmental Emergence of Fear-Learning in Fragile X Syndrome Open

Matthew N. Svalina, Christian A. Cea-Del Rio, J. Keenan Kushner, Abigail Levy, Serapio M. Baca , et al. · 2022

Fragile X Syndrome is a neurodevelopmental disorder and the most common monogenic cause of intellectual disability, autism spectrum disorders, and anxiety disorders. Loss of fragile x mental retardation protein results in disruptions of sy…

The Neurobiology of Infant Attachment-Trauma and Disruption of Parent–Infant Interactions Open

Nimra Naeem, Roseanna M. Zanca, Sylvie Weinstein, Alejandra Urquieta, Anna Sosa , et al. · 2022

Current clinical literature and supporting animal literature have shown that repeated and profound early-life adversity, especially when experienced within the caregiver–infant dyad, disrupts the trajectory of brain development to induce l…

Neurobiology of Parental Regulation of the Infant and Its Disruption by Trauma Within Attachment Open

Nina Graf, Roseanna M. Zanca, Wei Song, Elizabeth Zeldin, Roshni Raj , et al. · 2022

The complex process of regulating physiological functions and homeostasis during external and internal disruptions develops slowly in altricial species, with parental care functioning as a co-regulator of infant physiological and emotional…

The Added Value of Crosstalk Between Developmental Circuit Neuroscience and Clinical Practice to Inform the Treatment of Adolescent Anxiety Open

Heidi C. Meyer, Andrea Fields, Anna Vannucci, Danielle M. Gerhard, Paul Alexander Bloom , et al. · 2022

Significant advances have been made in recent years regarding the developmental trajectories of brain circuits and networks, revealing links between brain structure and function. Emerging evidence highlights the importance of developmental…

Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat Open

Brett S. East, Gloria Fleming, Samantha Vervoordt, Prachi Shah, Regina M. Sullivan , et al. · 2021

Bidirectional control of infant rat social behavior via dopaminergic innervation of the basolateral amygdala Open

Maya Opendak, Charlis Raineki, Rosemarie E. Perry, Millie Rincón‐Cortés, Soomin C. Song , et al. · 2021

Infant Attachment and Social Modification of Stress Neurobiology Open

Katherine Packard, Maya Opendak, Caroline Davis Soper, Haniyyah Sardar, Regina M. Sullivan · 2021

Decades of research have informed our understanding of how stress impacts the brain to perturb behavior. However, stress during development has received specific attention as this occurs during a sensitive period for scaffolding lifelong s…

Oxytocin neurons enable social transmission of maternal behaviour Open

Ioana Carcea, Naomi López Caraballo, Bianca Jones Marlin, Rumi Ooyama, Justin S. Riceberg , et al. · 2021

Maternal care, including by non-biological parents, is important for offspring survival 1–8 . Oxytocin 1,2,9–15 , which is released by the hypothalamic paraventricular nucleus (PVN), is a critical maternal hormone. In mice, oxytocin enable…

Early acquisition of threat conditioning in a selectively-bred anxiety-like rat phenotype: regulation by maternal presence and FGF2 Open

A. M. White, Da-Jeong Chang, Joanna H. Hider, Elaine K. Hebda‐Bauer, Cortney A. Turner , et al. · 2021

Temperament is an innate, stable predisposition towards particular emotional and behavioral responses. In humans, certain temperaments are associated with a heightened risk of developing anxiety later in life. Non-human animals, including …

Maternal continuous oral oxycodone self-administration alters pup affective/social communication but not spatial learning or sensory-motor function Open

Giulia Zanni, Patrese A. Robinson-Drummer, Ashlee A. Dougher, Hannah M. Deutsch, Matthew J. DeSalle , et al. · 2021

Basolateral Amygdala Hyperexcitability is Associated With Precocious Developmental Emergence of Fear-Learning in Fragile X Syndrome Open

Matthew N. Svalina, Christian A. Cea-Del Rio, Abigail Levy, Serapio M. Baca, Eartha Mae Guthman , et al. · 2021

Elevated infant cortisol is necessary but not sufficient for transmission of environmental risk to infant social development: Cross-species evidence of mother–infant physiological social transmission Open

Rosemarie E. Perry, Stephen H. Braren, Maya Opendak, Annie Brandes‐Aitken, Divija Chopra , et al. · 2020

Environmental adversity increases child susceptibility to disrupted developmental outcomes, but the mechanisms by which adversity can shape development remain unclear. A translational cross-species approach was used to examine stress-media…

Defining immediate effects of sensitive periods on infant neurobehavioral function Open

Regina M. Sullivan, Maya Opendak · 2020

Neurobiology of Infant Fear and Anxiety: Impacts of Delayed Amygdala Development and Attachment Figure Quality Open

Regina M. Sullivan, Maya Opendak · 2020

Maternal Continuous Oral Oxycodone Self-Administration Alters Pup Affective/Social Communication but not Spatial Learning or Sensory-Motor Function Open

Giulia Zanni, Patrese A. Robinson-Drummer, Ashlee A. Dougher, Hannah M. Deutsch, Matthew J. DeSalle , et al. · 2020

The broad use and misuse of prescription opioids during pregnancy has resulted in a surge of infants diagnosed with Neonatal Opioid Withdrawal Syndrome (NOWS). Short-term irritability and neurological complications are hallmarks of NOWS, b…

Adverse caregiving in infancy blunts neural processing of the mother Open

Maya Opendak, Emma Theisen, Anna Blomkvist, Kaitlin Hollis, Teresa Lind , et al. · 2020

Bidirectional Control of Infant Social Behavior by Dopaminergic Innervation of the Basolateral Amygdala Open

Maya Opendak, Charlis Raineki, Rosemarie E. Perry, Emma R. Wood, Katherine Packard , et al. · 2020

Adverse caregiving in infancy blunts neural processing of the mother: Translating across species Open

Maya Opendak, Emma Theisen, Anna Blomkvist, Kaitlin Hollis, Teresa Lind , et al. · 2019

The roots of psychopathology frequently take shape during infancy in the context of parent-infant interactions and adversity. Yet, neurobiological mechanisms linking these processes during infancy remain elusive. Here, using responses to a…

Enhancing Executive Functions Through Social Interactions: Causal Evidence Using a Cross-Species Model Open

Rosemarie E. Perry, Stephen H. Braren, Millie Rincón‐Cortés, Annie Brandes‐Aitken, Divija Chopra , et al. · 2019

It has long been theorized that humans develop higher mental functions, such as executive functions (EFs), within the context of interpersonal interactions and social relationships. Various components of social interactions, such as interp…

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