Richard P. Haslam
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View article: Assessing different physiological, seed yield and quality responses of camelina lines to drought
Assessing different physiological, seed yield and quality responses of camelina lines to drought Open
View article: Sustainable and available sources of omega-3 fatty acids for health: are the current dietary recommendations, food sources and legislation fit for purpose?
Sustainable and available sources of omega-3 fatty acids for health: are the current dietary recommendations, food sources and legislation fit for purpose? Open
The health benefits of the long-chain omega-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been known for over 50 years and underpin the UK population recommendation to consume >450 mg…
View article: Oilseed‐based metabolic engineering of astaxanthin and related ketocarotenoids using a plant‐derived pathway: Lab‐to‐field‐to‐application
Oilseed‐based metabolic engineering of astaxanthin and related ketocarotenoids using a plant‐derived pathway: Lab‐to‐field‐to‐application Open
Summary Ketocarotenoids, including astaxanthin, are red lipophilic pigments derived from the oxygenation of β‐carotene ionone rings. These carotenoids have exceptional antioxidant capacity and high commercial value as natural pigments, esp…
View article: Concerted transport and phosphorylation of diacylglycerol at ER–PM contact sites regulate phospholipid dynamics during stress
Concerted transport and phosphorylation of diacylglycerol at ER–PM contact sites regulate phospholipid dynamics during stress Open
A universal response of plants to environmental stresses is the activation of plasma membrane (PM) phospholipase C, which hydrolyzes phosphoinositides to produce soluble inositol phosphate and diacylglycerol (DAG). Because of their conical…
View article: Born of frustration: the emergence of <i>Camelina sativa</i> as a platform for lipid biotechnology
Born of frustration: the emergence of <i>Camelina sativa</i> as a platform for lipid biotechnology Open
The emerging crop Camelina sativa (L.) Crantz (camelina) is a Brassicaceae oilseed with a rapidly growing reputation for the deployment of advanced lipid biotechnology and metabolic engineering. Camelina is recognized by agronomists for it…
View article: Concerted Transport and Phosphorylation of Diacylglycerol at ER-PM Contacts Sites Regulates Phospholipid Dynamics During Stress
Concerted Transport and Phosphorylation of Diacylglycerol at ER-PM Contacts Sites Regulates Phospholipid Dynamics During Stress Open
A universal response of plants to environmental stresses is the activation of plasma membrane (PM) phospholipase C (PLC) that hydrolyzes phosphatidylinositol phosphate (PIP) to produce soluble inositol phosphate (IP) and diacylglycerol (DA…
View article: Penn Healthy Diet survey: pilot validation and scoring
Penn Healthy Diet survey: pilot validation and scoring Open
Though diet quality is widely recognised as linked to risk of chronic disease, health systems have been challenged to find a user-friendly, efficient way to obtain information about diet. The Penn Healthy Diet (PHD) survey was designed to …
View article: The potential of integrative phenomics to harness underutilized crops for improving stress resilience
The potential of integrative phenomics to harness underutilized crops for improving stress resilience Open
The current agricultural and food system faces diverse and increasing challenges. These
\ninclude feeding an ever-growing human population, expected to reach about 10 billion by
\n2050 combined with societal disruption, and the need to cop…
View article: Corrigendum to: Prospects to improve the nutritional quality of crops
Corrigendum to: Prospects to improve the nutritional quality of crops Open
View article: Tackling functional redundancy of Arabidopsis fatty acid elongase complexes
Tackling functional redundancy of Arabidopsis fatty acid elongase complexes Open
Very-long-chain fatty acids (VLCFA) are precursors for various lipids playing important physiological and structural roles in plants. Throughout plant tissues, VLCFA are present in multiple lipid classes essential for membrane homeostasis,…
View article: Enhancing the accumulation of eicosapentaenoic acid and docosahexaenoic acid in transgenic Camelina through the <scp>CRISPR‐Cas9</scp> inactivation of the competing <scp><i>FAE1</i></scp> pathway
Enhancing the accumulation of eicosapentaenoic acid and docosahexaenoic acid in transgenic Camelina through the <span>CRISPR‐Cas9</span> inactivation of the competing <span><i>FAE1</i></span> pathway Open
Omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs), eicosapentaenoic acid (EPA; 20:5Δ5,8,11,14,17) and docosahexaenoic acid (DHA; 22:6Δ4,7,10,13,16,19) are now accepted as being essential components of a healthy, balanced diet (Napi…
View article: Using field evaluation and systematic iteration to rationalize the accumulation of omega‐3 long‐chain polyunsaturated fatty acids in transgenic <i>Camelina sativa</i>
Using field evaluation and systematic iteration to rationalize the accumulation of omega‐3 long‐chain polyunsaturated fatty acids in transgenic <i>Camelina sativa</i> Open
Summary The Brassicaceae Camelina sativa (gold of pleasure) is now an established niche crop and being used as a transgenic host for a range of novel seed traits. Most notable of these is the accumulation of omega‐3 long‐chain polyunsatura…
View article: Prospects to improve the nutritional quality of crops
Prospects to improve the nutritional quality of crops Open
A growing world population as well as the need to enhance sustainability and health create challenges for crop breeding. To address these challenges, not only quantitative but also qualitative improvements are needed, especially regarding …
View article: Synaptotagmins at the endoplasmic reticulum–plasma membrane contact sites maintain diacylglycerol homeostasis during abiotic stress
Synaptotagmins at the endoplasmic reticulum–plasma membrane contact sites maintain diacylglycerol homeostasis during abiotic stress Open
Endoplasmic reticulum–plasma membrane contact sites (ER–PM CS) play fundamental roles in all eukaryotic cells. Arabidopsis thaliana mutants lacking the ER–PM protein tether synaptotagmin1 (SYT1) exhibit decreased PM integrity under multipl…
View article: Accumulation and deposition of triacylglycerols in the starchy endosperm of wheat grain
Accumulation and deposition of triacylglycerols in the starchy endosperm of wheat grain Open
A combination of lipidomics, transcriptomics and bioimaging has been used to study triacylglycerol synthesis and deposition in the developing starchy endosperm of wheat. The content of TAG increased between 14 and 34 days after anthesis, f…
View article: Lipidomic Analysis of Plasma from Healthy Men and Women Shows Phospholipid Class and Molecular Species Differences between Sexes
Lipidomic Analysis of Plasma from Healthy Men and Women Shows Phospholipid Class and Molecular Species Differences between Sexes Open
The phospholipid composition of lipoproteins is determined by the specificity of hepatic phospholipid biosynthesis. Plasma phospholipid 20:4n‐6 and 22:6n‐3 concentrations are higher in women than in men. We used this sex difference in a li…
View article: Synaptotagmins Maintain Diacylglycerol Homeostasis at Endoplasmic Reticulum-Plasma Membrane Contact Sites during Abiotic Stress
Synaptotagmins Maintain Diacylglycerol Homeostasis at Endoplasmic Reticulum-Plasma Membrane Contact Sites during Abiotic Stress Open
SUMMARY Endoplasmic Reticulum-Plasma Membrane contact sites (ER-PM CS) play fundamental roles in all eukaryotic cells. Arabidopsis mutants lacking the ER-PM protein tether synaptotagmin1 (SYT1) exhibit decreased plasma membrane (PM) integr…
View article: Genetic variation in wheat grain quality is associated with differences in the galactolipid content of flour and the gas bubble properties of dough liquor
Genetic variation in wheat grain quality is associated with differences in the galactolipid content of flour and the gas bubble properties of dough liquor Open
Lipids affect the quality of wheat flour for breadmaking. One possible mechanism is stabilization of the gas cells which are formed during dough mixing and expanded during fermentation, leading to a greater loaf volume and evenness of text…
View article: Overexpression of an endogenous type 2 diacylglycerol acyltransferase in the marine diatom Phaeodactylum tricornutum enhances lipid production and omega-3 Long Chain Polyunsaturated Fatty Acid content
Overexpression of an endogenous type 2 diacylglycerol acyltransferase in the marine diatom Phaeodactylum tricornutum enhances lipid production and omega-3 Long Chain Polyunsaturated Fatty Acid content Open
Background: Oleaginous microalgae represent a valuable resource for the production of high value molecules. Considering the importance of omega-3 long chain polyunsaturated fatty acids (LC-PUFAs) for human health and nutrition the yields o…
View article: Overexpression of an endogenous type 2 diacylglycerol acyltransferase in the marine diatom Phaeodactylum tricornutum enhances lipid production and omega-3 long-chain polyunsaturated fatty acid content
Overexpression of an endogenous type 2 diacylglycerol acyltransferase in the marine diatom Phaeodactylum tricornutum enhances lipid production and omega-3 long-chain polyunsaturated fatty acid content Open
View article: Phytochrome-Dependent Temperature Perception Modulates Isoprenoid Metabolism
Phytochrome-Dependent Temperature Perception Modulates Isoprenoid Metabolism Open
Changes in environmental temperature influence many aspects of plant metabolism; however, the underlying regulatory mechanisms remain poorly understood. In addition to their role in light perception, phytochromes (PHYs) have been recently …
View article: High level accumulation of EPA and DHA in field‐grown transgenic Camelina – a multi‐territory evaluation of TAG accumulation and heterogeneity
High level accumulation of EPA and DHA in field‐grown transgenic Camelina – a multi‐territory evaluation of TAG accumulation and heterogeneity Open
The transgene‐directed accumulation of non‐native omega‐3 long chain polyunsaturated fatty acids in the seed oil of Camelina sativa (Camelina) was evaluated in the field, in distinct geographical and regulatory locations. A construct, DHA2…
View article: Overexpression of a type 2 diacylglycerol acyltransferase in the marine diatom Phaeodactylum tricornutum enhances lipid production and omega-3 Long Chain Polyunsaturated Fatty Acid content
Overexpression of a type 2 diacylglycerol acyltransferase in the marine diatom Phaeodactylum tricornutum enhances lipid production and omega-3 Long Chain Polyunsaturated Fatty Acid content Open
Background: Oleaginous microalgae represent a valuable resource for the production of high value molecules. Considering the importance of omega-3 long chain polyunsaturated fatty acids (LC-PUFAs) for human health and nutrition the yields o…
View article: Characterization of Oil Palm Acyl-CoA-Binding Proteins and Correlation of Their Gene Expression with Oil Synthesis
Characterization of Oil Palm Acyl-CoA-Binding Proteins and Correlation of Their Gene Expression with Oil Synthesis Open
Acyl-CoA-binding proteins (ACBPs) are involved in binding and trafficking acyl-CoA esters in eukaryotic cells. ACBPs contain a well-conserved acyl-CoA-binding domain. Their various functions have been characterized in the model plant Arabi…
View article: Impairment of DHA synthesis alters the expression of neuronal plasticity markers and the brain inflammatory status in mice
Impairment of DHA synthesis alters the expression of neuronal plasticity markers and the brain inflammatory status in mice Open
Docosahexaenoic acid (DHA) is a ω‐3 fatty acid typically obtained from the diet or endogenously synthesized through the action of elongases (ELOVLs) and desaturases. DHA is a key central nervous system constituent and the precursor of seve…
View article: Arabidopsis cytosolic acyl‐CoA‐binding proteins function in determining seed oil composition
Arabidopsis cytosolic acyl‐CoA‐binding proteins function in determining seed oil composition Open
As plant seed oils provide animals with essential fatty acids (FAs), genes that regulate plant lipid metabolism have been used in genetic manipulation to improve dietary seed oil composition and benefit human health. Herein, the Arabidopsi…
View article: The overexpression of rice <scp>ACYL</scp>‐<scp>CoA</scp>‐<scp>BINDING PROTEIN</scp>2 increases grain size and bran oil content in transgenic rice
The overexpression of rice <span>ACYL</span>‐<span>CoA</span>‐<span>BINDING PROTEIN</span>2 increases grain size and bran oil content in transgenic rice Open
Summary As Oryza sativa (rice) seeds represent food for over three billion people worldwide, the identification of genes that enhance grain size and composition is much desired. Past reports have indicated that Arabidopsis thaliana acyl‐Co…
View article: Phosphorus use efficiency and fertilizers: future opportunities for improvements
Phosphorus use efficiency and fertilizers: future opportunities for improvements Open
The continued supply of phosphate fertilizers that underpin global food production is an imminent crisis. The rock phosphate deposits on which the world depends are not only finite, but some are contaminated, and many are located in geopol…
View article: Oat and lipolysis: Food matrix effect
Oat and lipolysis: Food matrix effect Open
View article: Structural and functional analyses of Rubisco from arctic diatom species reveal unusual posttranslational modifications
Structural and functional analyses of Rubisco from arctic diatom species reveal unusual posttranslational modifications Open
The catalytic performance of the major CO2-assimilating enzyme, ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), restricts photosynthetic productivity. Natural diversity in the catalytic properties of Rubisco indicates…