Explanipedia

FM-dye inhibition of Piezo2 relieves acute inflammatory and osteoarthritis knee pain in mice of both sexes Open

Natalie S. Adamczyk, Shingo Ishihara, Alia M. Obeidat, Dongjun Ren, Richard J. Miller , et al. · 2025

Musculoskeletal pain is a significant burden affecting billions of people with little progress in the development of pharmaceutical pain relief options. The mechanically-activated ion channel Piezo2 has been shown to play a role in mechani…

Keratinocyte-derived extracellular vesicles in painful diabetic neuropathy Open

James S. Coy-Dibley, Nirupa D. Jayaraj, Dongjun Ren, Paola Pacifico, A. Belmadani , et al. · 2024

Painful diabetic neuropathy (PDN) is a challenging complication of diabetes with patients experiencing a painful and burning sensation in their extremities. Existing treatments provide limited relief without addressing the underlying mecha…

Keratinocyte-Derived Exosomes in Painful Diabetic Neuropathy Open

James S. Coy-Dibley, Nirupa D. Jayaraj, Dongjun Ren, Paola Pacifico, Abdelhak Belmadani , et al. · 2024

Painful diabetic neuropathy (PDN) is a challenging complication of diabetes with patients experiencing a painful and burning sensation in their extremities. Existing treatments provide limited relief without addressing the underlying mecha…

Activation Of Keratinocyte Gq-Linked G-Protein Coupled Receptors Enhances Dorsal Root Ganglion Neuron Voltage-Gated Sodium Channel Activity And Neuronal Excitability Open

Abdelhak Belamadni, Dongjun Ren, Nirupa D. Jayaraj, Richard J. Miller, Carlos G. Vanoye , et al. · 2023

Effects of Small Molecule Ligands on ACKR3 Receptors Open

Brittany E. Hopkins, Ikuo Masuho, Dongjun Ren, Iredia D. Iyamu, Wei Lv , et al. · 2022

Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis Open

Alia M. Obeidat, Matthew J. Wood, Shingo Ishihara, Jie Li, Lai Wang , et al. · 2022

Osteoarthritis is a very common painful joint disease, for which few treatment options exist. New non-opioid targets are needed for addressing osteoarthritis pain, which is mechanical in nature and associated with daily activities such as …

Gβ Association and Effector Interaction Selectivities of the Divergent Gγ Subunit Gγ 13 Open

Bonita L. Blake, Michele R. Wing, Janice Y. Zhou, Qiubo Lei, Jennie R. Hillmann , et al. · 2021

G gamma(13) is a divergent member of the G gamma subunit family considered to be a component of the gustducin G-protein heterotrimer involved in bitter and sweet taste reception in taste bud cells. G gamma(13) contains a C-terminal asparag…

Orai1 channels are essential for amplification of glutamate-evoked Ca2+ signals in dendritic spines to regulate working and associative memory Open

Mohammad Mehdi Maneshi, Anna B. Toth, Toshiyuki Ishii, Kotaro Hori, Shogo Tsujikawa , et al. · 2021

(Cell Reports 33, 108464-1–108464-14.e1–e6; December 1, 2020) In the originally published version of this article, Figure S1G showed an image of Orai1 expression from the Allen Brain Atlas website. Because of an error in the unsupervised s…

Orai1 Channels Are Essential for Amplification of Glutamate-Evoked Ca2+ Signals in Dendritic Spines to Regulate Working and Associative Memory Open

Mohammad Mehdi Maneshi, Anna B. Toth, Toshiyuki Ishii, Kotaro Hori, Shogo Tsujikawa , et al. · 2020

Randomized Controlled Trial of Difelikefalin for Chronic Pruritus in Hemodialysis Patients Open

Steven Fishbane, Vandana Mathur, Michael J. Germain, Shayan Shirazian, Sarbani Bhaduri , et al. · 2020

A Comparison of PROMIS UE Versus PF: Ceiling and Floor Effects, Duration to Completion, and Correlation to PROMIS PI and Depression Open

David N. Bernstein, Ronald Gonzalez, Danielle Wilbur, Constantinos Ketonis, Richard J. Miller , et al. · 2018

Preoperative PROMIS Scores Predict Postoperative PROMIS Score Improvement for Patients Undergoing Hand Surgery Open

David N. Bernstein, Jeff Houck, Ronald Gonzalez, Danielle Wilbur, Richard J. Miller , et al. · 2018

Background: Patient-Reported Outcomes Measurement Information System (PROMIS) can be used alongside preoperative patient characteristics to set postsurgery expectations. This study aimed to analyze whether preoperative scores can predict s…

TRPV1 and the MCP-1/CCR2 Axis Modulate Post-UTI Chronic Pain Open

John M. Rosen, Ryan E. Yaggie, Patrick J. Woida, Richard J. Miller, Anthony J. Schaeffer , et al. · 2018

Evidence for an early innate immune response in the motor cortex of ALS Open

Javier H. Jara, Barış Genç, Macdonell J. Stanford, Peter Pytel, Raymond P. Roos , et al. · 2017

Chemogenetic Inhibition of Pain Neurons in a Mouse Model of Osteoarthritis Open

Rachel E. Miller, Shingo Ishihara, Bula J. Bhattacharyya, Ada Delaney, Daniela M. Menichella , et al. · 2017

Objective To determine the ability of drugs that activate inhibitory G protein–coupled receptors (GPCRs) expressed in peripheral voltage‐gated sodium channel 1.8 (Na V 1.8)–positive sensory neurons to control osteoarthritis (OA)–associated…

Emerging Targets for the Management of Osteoarthritis Pain Open

Anne‐Marie Malfait, Richard J. Miller · 2016

Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonists Open

Rama K. Mishra, Andrew Shum, Leonidas C. Platanias, Richard J. Miller, Gary E. Schiltz · 2016

The chemokine CXCL12 (SDF-1) and its cognate receptor CXCR4 are involved in a large number of physiological processes including HIV-1 infectivity, inflammation, tumorigenesis, stem cell migration and autoimmune diseases. While previous eff…

Ganglioside GM3 synthase depletion reverses neuropathic pain and small fiber neuropathy in diet-induced diabetic mice Open

Daniela M. Menichella, Nirupa D. Jayaraj, Heather M. Wilson, Dongjun Ren, Kelsey S. Flood , et al. · 2016

Background Small fiber neuropathy is a well-recognized complication of type 2 diabetes and has been shown to be responsible for both neuropathic pain and impaired wound healing. In previous studies, we have demonstrated that ganglioside GM…

Damage‐Associated Molecular Patterns Generated in Osteoarthritis Directly Excite Murine Nociceptive Neurons Through Toll‐like Receptor 4 Open

Rachel E. Miller, Abdelhak Belmadani, Shingo Ishihara, Phuong B. Tran, Dongjun Ren , et al. · 2015

Objective To determine whether selected damage‐associated molecular patterns (DAMPs) present in the osteoarthritic (OA) joints of mice excite nociceptors through Toll‐like receptor 4 (TLR‐4). Methods The ability of S100A8 and α 2 ‐macroglo…

Visualization of Sensory Neurons and Their Projections in an Upper Motor Neuron Reporter Line Open

Barış Genç, Amiko K. B. Lagrimas, Pınar Kuru Bektaşoğlu, R. Hess, M Tu , et al. · 2015

Visualization of peripheral nervous system axons and cell bodies is important to understand their development, target recognition, and integration into complex circuitries. Numerous studies have used protein gene product (PGP) 9.5 [a.k.a. …

Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS Open

Jennifer A. Watson, Bula J. Bhattacharyya, Jada H. Vaden, Julie A. Wilson, Mert Icyuz , et al. · 2015

Neurons are particularly vulnerable to perturbations in endo-lysosomal transport, as several neurological disorders are caused by a primary deficit in this pathway. In this report, we used positional cloning to show that the spontaneously …

Localized CCR2 Activation in the Bone Marrow Niche Mobilizes Monocytes by Desensitizing CXCR4 Open

Hosung Jung, Divakar S. Mithal, Jeong Eun Park, Richard J. Miller · 2015

Inflammatory (classical) monocytes residing in the bone marrow must enter the bloodstream in order to combat microbe infection. These monocytes express high levels of CCR2, a chemokine receptor whose activation is required for them to exit…

Pattern of CXCR7 Gene Expression in Mouse Brain Under Normal and Inflammatory Conditions Open

Ghazal Banisadr, Joseph R. Podojil, Stephen D. Miller, Richard J. Miller · 2015

Identification of a sustained neurogenic zone at the dorsal surface of the adult mouse hippocampus and its regulation by the chemokine SDF‐1 Open

Abdelhak Belmadani, Dongjun Ren, Bula J. Bhattacharyya, Katharina B. Rothwangl, Thomas J. Hope , et al. · 2015

We identified a previously unknown neurogenic region at the dorsal surface of the hippocampus; (the “subhippocampal zone,” SHZ) in the adult brain. Using a reporter mouse in which SHZ cells and their progeny could be traced through the exp…

A critical role of Src family kinase in SDF-1/CXCR4-mediated bone-marrow progenitor cell recruitment to the ischemic heart Open

Min Cheng, Kai Huang, Junlan Zhou, Dewen Yan, Yaoliang Tang , et al. · 2015

Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction Open

Jada H. Vaden, Bula J. Bhattacharyya, Ping-Chung Chen, Jennifer A. Watson, Andrea G. Marshall , et al. · 2015

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