Derrick R. Samuelson
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View article: Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion Open
Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human t…
View article: Alcohol induces α2‐6sialo mucin <scp>O</scp> ‐glycans that kill <scp>U</scp> 937 macrophages mediated by sialic acid‐binding immunoglobulin‐like lectin 7 ( <scp>S</scp> iglec 7)
Alcohol induces α2‐6sialo mucin <span>O</span> ‐glycans that kill <span>U</span> 937 macrophages mediated by sialic acid‐binding immunoglobulin‐like lectin 7 ( <span>S</span> iglec 7) Open
Alcohol misuse increases infections and cancer fatalities, but mechanisms underlying its toxicity are ill‐defined. We show that alcohol treatment of human tracheobronchial epithelial cells leads to inactivation of giantin‐mediated Golgi ta…
View article: Diet-microbiome interactions influence lung function in chronic obstructive pulmonary disease
Diet-microbiome interactions influence lung function in chronic obstructive pulmonary disease Open
Chronic Obstructive Pulmonary Disease (COPD) affects 30 million Americans. Previous epidemiologic work has shown that diet can impact pulmonary function in those with and without COPD. Diet is also a major driver of gut microbiome composit…
View article: Zinc Protects against Swine Barn Dust-Induced Cilia Slowing
Zinc Protects against Swine Barn Dust-Induced Cilia Slowing Open
Agricultural workers exposed to organic dust from swine concentrated animal feeding operations (CAFOs) have increased chances of contracting chronic lung disease. Mucociliary clearance represents a first line of defense against inhaled dus…
View article: Regulation of Natural Killer Cell TGF-β and AhR Signaling Pathways Via the Intestinal Microbiota is Critical for Host Defense Against Alcohol-Associated Bacterial Pneumonia
Regulation of Natural Killer Cell TGF-β and AhR Signaling Pathways Via the Intestinal Microbiota is Critical for Host Defense Against Alcohol-Associated Bacterial Pneumonia Open
Alcohol use is an independent risk factor for the development of bacterial pneumonia due, in part, to impaired mucus-facilitated clearance, macrophage phagocytosis, and recruitment of neutrophils. Alcohol consumption is also known to reduc…
View article: Human Alcohol-Microbiota Mice have Increased Susceptibility to Bacterial Pneumonia
Human Alcohol-Microbiota Mice have Increased Susceptibility to Bacterial Pneumonia Open
Preclinical studies have shown that chronic alcohol abuse leads to alterations in the gastrointestinal microbiota that are associated with behavior changes, physiological alterations, and immunological effects. However, such studies have b…
View article: The Inherited Intestinal Microbiota from Myeloid-Specific ZIP8KO Mice Impairs Pulmonary Host Defense against Pneumococcal Pneumonia
The Inherited Intestinal Microbiota from Myeloid-Specific ZIP8KO Mice Impairs Pulmonary Host Defense against Pneumococcal Pneumonia Open
Intestinal dysbiosis increases susceptibility to infection through the alteration of metabolic profiles, which increases morbidity. Zinc (Zn) homeostasis in mammals is tightly regulated by 24 Zn transporters. ZIP8 is unique in that it is r…
View article: A critical review of recent knowledge of alcohol's effects on the immunological response in different tissues
A critical review of recent knowledge of alcohol's effects on the immunological response in different tissues Open
Alcohol misuse contributes to the dysregulation of immune responses and multiorgan dysfunction across various tissues, which are associated with higher risk of morbidity and mortality in people with alcohol use disorders. Organ‐specific im…
View article: Innate lymphocytes: Role in alcohol-induced immune dysfunction
Innate lymphocytes: Role in alcohol-induced immune dysfunction Open
Alcohol use is known to alter the function of both innate and adaptive immune cells, such as neutrophils, macrophages, B cells, and T cells. Immune dysfunction has been associated with alcohol-induced end-organ damage. The role of innate l…
View article: A Selective and Sensitive LC-MS/MS Method for Quantitation of Indole in Mouse Serum and Tissues
A Selective and Sensitive LC-MS/MS Method for Quantitation of Indole in Mouse Serum and Tissues Open
Indole is an endogenous substance currently being evaluated as a biomarker for ulcerative colitis, irritable bowel syndrome, Crohn’s disease and non-alcoholic fatty liver disease. A novel, selective, and sensitive method using liquid chrom…
View article: Divalent Metal Uptake and the Role of ZIP8 in Host Defense Against Pathogens
Divalent Metal Uptake and the Role of ZIP8 in Host Defense Against Pathogens Open
Manganese (Mn) and Zinc (Zn) are essential micronutrients whose concentration and location within cells are tightly regulated at the onset of infection. Two families of Zn transporters (ZIPs and ZnTs) are largely responsible for regulation…
View article: The Role of Bacterial Membrane Vesicles in Human Health and Disease
The Role of Bacterial Membrane Vesicles in Human Health and Disease Open
Bacterial membrane vesicles (MVs) are nanoparticles derived from the membrane components of bacteria that transport microbial derived substances. MVs are ubiquitous across a variety of terrestrial and marine environments and vary widely in…
View article: Host innate and adaptive immunity shapes the gut microbiota biogeography
Host innate and adaptive immunity shapes the gut microbiota biogeography Open
The gut microbiota has a fundamental role in the development and the maturation of the host immune system. Both innate and adaptive immune cells have critical functions in microbial pathogen containment and clearance, but the regulation of…
View article: ZIP8-Mediated Intestinal Dysbiosis Impairs Pulmonary Host Defense against Bacterial Pneumonia
ZIP8-Mediated Intestinal Dysbiosis Impairs Pulmonary Host Defense against Bacterial Pneumonia Open
Pneumococcal pneumonia is a leading cause of morbidity and mortality worldwide. An increased susceptibility is due, in part, to compromised immune function. Zinc is required for proper immune function, and an insufficient dietary intake in…
View article: Critical Role of Zinc Transporter (ZIP8) in Myeloid Innate Immune Cell Function and the Host Response against Bacterial Pneumonia
Critical Role of Zinc Transporter (ZIP8) in Myeloid Innate Immune Cell Function and the Host Response against Bacterial Pneumonia Open
Zinc (Zn) is required for proper immune function and host defense. Zn homeostasis is tightly regulated by Zn transporters that coordinate biological processes through Zn mobilization. Zn deficiency is associated with increased susceptibili…
View article: Alcohol‐associated intestinal dysbiosis alters mucosal‐associated invariant T‐cell phenotype and function
Alcohol‐associated intestinal dysbiosis alters mucosal‐associated invariant T‐cell phenotype and function Open
Background Chronic alcohol consumption is associated with a compromised innate and adaptive immune responses to infectious disease. Mucosa‐associated invariant T (MAIT) cells play a critical role in antibacterial host defense. However, whe…
View article: The respiratory tract microbial biogeography in alcohol use disorder
The respiratory tract microbial biogeography in alcohol use disorder Open
Individuals with alcohol use disorders (AUDs) are at an increased risk of pneumonia and acute respiratory distress syndrome. Data of the lung microbiome in the setting of AUDs are lacking. The objective of this study was to determine the m…
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OBJECTIVES/SPECIFIC AIMS: Alcohol consumption perturbs the normal intestinal microbial communities (alcohol dysbiosis). To begin to investigate the relationship between alcohol-mediated dysbiosis and host defense we developed an alcohol dy…
View article: Changes in the gut microbial communities following addition of walnuts to the diet
Changes in the gut microbial communities following addition of walnuts to the diet Open
Walnuts are rich in omega-3 fatty acids, phytochemicals and antioxidants making them unique compared to other foods. Consuming walnuts has been associated with health benefits including a reduced risk of heart disease and cancer. Dysbiosis…
View article: Alcohol-associated intestinal dysbiosis impairs pulmonary host defense against Klebsiella pneumoniae
Alcohol-associated intestinal dysbiosis impairs pulmonary host defense against Klebsiella pneumoniae Open
Chronic alcohol consumption perturbs the normal intestinal microbial communities (dysbiosis). To investigate the relationship between alcohol-mediated dysbiosis and pulmonary host defense we developed a fecal adoptive transfer model, which…