Richard A. Shaffer
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View article: Effects of genetically predicted posttraumatic stress disorder on autoimmune phenotypes
Effects of genetically predicted posttraumatic stress disorder on autoimmune phenotypes Open
Observational studies suggest that posttraumatic stress disorder (PTSD) increases risk for various autoimmune diseases. Insights into shared biology and causal relationships between these diseases may inform intervention approaches to PTSD…
View article: Data from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma
Data from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma Open
Purpose:Patients with recurrent high-grade gliomas (HGG) are usually managed with alkylating chemotherapy ± bevacizumab. However, prognosis remains very poor. Preclinically, we showed that HGGs are a target for arginine depletion with pega…
View article: Figure S3 from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma
Figure S3 from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma Open
Effects of ADI-PEG20 on the folate pathway
View article: Data from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma
Data from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma Open
Purpose:Patients with recurrent high-grade gliomas (HGG) are usually managed with alkylating chemotherapy ± bevacizumab. However, prognosis remains very poor. Preclinically, we showed that HGGs are a target for arginine depletion with pega…
View article: Figure S3 from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma
Figure S3 from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma Open
Effects of ADI-PEG20 on the folate pathway
View article: Figure S2 from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma
Figure S2 from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma Open
Kaplan Meier plots for PFS and OS
View article: Figure S1 from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma
Figure S1 from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma Open
ASS1 immunohistochemistry
View article: Figure S1 from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma
Figure S1 from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma Open
ASS1 immunohistochemistry
View article: Figure S2 from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma
Figure S2 from A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma Open
Kaplan Meier plots for PFS and OS
View article: Association of Race and Major Adverse Cardiac Events (MACE): The Atherosclerosis Risk in Communities (ARIC) Cohort
Association of Race and Major Adverse Cardiac Events (MACE): The Atherosclerosis Risk in Communities (ARIC) Cohort Open
Background and Aims . To evaluate the association of self-reported race with major adverse cardiac events (MACE) and modification of this association by paraoxonase gene ( PON 1, PON 2, and PON 3) single nucleotide polymorphisms (SNPs). Me…
View article: Association of Race and Change in Ankle-Brachial Index: The Atherosclerosis Risk in Communities (ARIC) Cohort
Association of Race and Change in Ankle-Brachial Index: The Atherosclerosis Risk in Communities (ARIC) Cohort Open
Objective: This study evaluates the association of self-reported race with change in ankle-brachial index (ABI) over time and modification of this association by paraoxonase gene (PON1, PON2 and PON3) single nucleotide polymorphisms (SNPs)…
View article: Longitudinal survey of condom use across a US Navy and Marine Corps shipboard deployment
Longitudinal survey of condom use across a US Navy and Marine Corps shipboard deployment Open
Objectives Condoms are highly effective in preventing sexually transmitted infections (STIs) but implementation is often inconsistent with use rarely examined across travel transition periods. We examined the prevalence of condom use among…
View article: Self-reported HIV-positive status but subsequent HIV-negative test result using rapid diagnostic testing algorithms among seven sub-Saharan African military populations
Self-reported HIV-positive status but subsequent HIV-negative test result using rapid diagnostic testing algorithms among seven sub-Saharan African military populations Open
HIV rapid diagnostic tests (RDTs) combined in an algorithm are the current standard for HIV diagnosis in many sub-Saharan African countries, and extensive laboratory testing has confirmed HIV RDTs have excellent sensitivity and specificity…
View article: Alcohol Misuse and Associated Risk Factors Across a Shipboard Deployment Among Active Duty US Navy and Marine Corps Personnel
Alcohol Misuse and Associated Risk Factors Across a Shipboard Deployment Among Active Duty US Navy and Marine Corps Personnel Open
Background Alcohol misuse rates are elevated in the US military. Relevant longitudinal data are rare in deployed shipboard personnel. We examined the prevalence of hazardous and dependent alcohol misuse at 3 months prior to (T1), during (T…
View article: Factors Associated with Not Using a Condom at Last Sex Among Sexually Active US Navy and Marine Corps Personnel Across a Shipboard Deployment
Factors Associated with Not Using a Condom at Last Sex Among Sexually Active US Navy and Marine Corps Personnel Across a Shipboard Deployment Open
Background Condom use is highly effective in preventing sexually transmitted infections (STIs); however, data on this are limited among US military personnel who may be at a higher risk for STI acquisition across a deployment cycle. This s…
View article: Maternal Age at Childbirth and Parity as Predictors of Longevity Among Women in the United States: The Women’s Health Initiative
Maternal Age at Childbirth and Parity as Predictors of Longevity Among Women in the United States: The Women’s Health Initiative Open
Objectives. To examine associations of maternal age at childbirth and parity with survival to age 90 years (longevity). Methods. We performed a prospective study among a multiethnic cohort of postmenopausal US women in the Women’s Health I…
View article: Associations of Accelerometer-Measured and Self-Reported Sedentary Time With Leukocyte Telomere Length in Older Women
Associations of Accelerometer-Measured and Self-Reported Sedentary Time With Leukocyte Telomere Length in Older Women Open
Few studies have assessed the association of sedentary time with leukocyte telomere length (LTL). In a cross-sectional study conducted in 2012-2013, we examined associations of accelerometer-measured and self-reported sedentary time with L…
View article: Replication of Genome-Wide Association Study Findings of Longevity in White, African American, and Hispanic Women: The Women’s Health Initiative
Replication of Genome-Wide Association Study Findings of Longevity in White, African American, and Hispanic Women: The Women’s Health Initiative Open
Future studies are needed to identify novel loci associated with longevity in African American and Hispanic women to determine biologic pathways regulating life span in these groups.
View article: Ages at menarche and menopause and reproductive lifespan as predictors of exceptional longevity in women: the Women's Health Initiative
Ages at menarche and menopause and reproductive lifespan as predictors of exceptional longevity in women: the Women's Health Initiative Open
Objective: The aim of the present study was to investigate associations between reproductive factors and survival to age 90 years. Methods: This was a prospective study of postmenopausal women from the Women's Health Initiative recruited f…