Richard Brinsley Sheridan
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View article: Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia
Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia Open
Blocking the pyrimidine nucleotide de novo synthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH) results in the cell cycle arrest and/or differentiation of rapidly proliferating cells including activated lymphocytes, cancer …
View article: Polyphenolic Promiscuity, Inflammation-coupled Specificity: Whether PAINs Filters Mask an Antiviral Asset
Polyphenolic Promiscuity, Inflammation-coupled Specificity: Whether PAINs Filters Mask an Antiviral Asset Open
The Covid-19 pandemic has elicited much laboratory and clinical research attention on vaccines, mAbs, and certain small-molecule antivirals against SARS-CoV-2 infection. By contrast, there has been comparatively little attention on plant-d…
View article: Inflammation-mediated Deglucuronidation and Promiscuous-binding Behavior of Polyphenols for Antiviral Assaying and Trialing with Relevance to COVID-19
Inflammation-mediated Deglucuronidation and Promiscuous-binding Behavior of Polyphenols for Antiviral Assaying and Trialing with Relevance to COVID-19 Open
The Covid-19 pandemic has elicited much laboratory and clinical research attention on vaccines, mAbs, and certain small-molecule antivirals against SARS-CoV-2 infection. By contrast, there has been comparatively little attention on plant-d…
View article: Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent
Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent Open
PTC596 is an investigational small-molecule tubulin-binding agent. Unlike other tubulin-binding agents, PTC596 is orally bioavailable and is not a P-glycoprotein substrate. So as to characterize PTC596 to position the molecule for optimal …
View article: Road mapping workshop report on overcoming barriers to adoption of composites in sustainable infrastructure
Road mapping workshop report on overcoming barriers to adoption of composites in sustainable infrastructure Open
Certain commercial entities, equipment, or materials may be identified in this document in order to describe an experimental procedure or concept adequately.Such identification is not intended to imply recommendation