Thomas J. Wang
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View article: Pulmonary lymphangiogenesis promotes lung B cell responses and bronchus-associated lymphoid tissue (BALT) initiation in chronic allergic asthma 2744
Pulmonary lymphangiogenesis promotes lung B cell responses and bronchus-associated lymphoid tissue (BALT) initiation in chronic allergic asthma 2744 Open
Description Bronchus-associated lymphoid tissue (BALT) is associated with severe asthma; however, its initiation is incompletely understood. In chronic lung infection models, lymphangiogenesis (LAG), driven by VEGF-C/VEGFR-3 signaling, occ…
View article: Comparative Performance of Machine Learning Classifiers for Photovoltaic Mapping in Arid Regions Using Google Earth Engine
Comparative Performance of Machine Learning Classifiers for Photovoltaic Mapping in Arid Regions Using Google Earth Engine Open
With increasing energy demand and advancing carbon neutrality goals, arid regions—key areas for centralized photovoltaic (PV) station development in China—urgently require efficient and accurate remote sensing techniques to support spatial…
View article: Bleeding Rectal Pseudoaneurysm Following Endoscopic Submucosal Dissection Managed with Endoscopic Ultrasound-Guided Absorbable Gelatin Sponge Injection
Bleeding Rectal Pseudoaneurysm Following Endoscopic Submucosal Dissection Managed with Endoscopic Ultrasound-Guided Absorbable Gelatin Sponge Injection Open
View article: Voxtral
Voxtral Open
We present Voxtral Mini and Voxtral Small, two multimodal audio chat models. Voxtral is trained to comprehend both spoken audio and text documents, achieving state-of-the-art performance across a diverse range of audio benchmarks, while pr…
View article: MedHELM: Holistic Evaluation of Large Language Models for Medical Tasks
MedHELM: Holistic Evaluation of Large Language Models for Medical Tasks Open
While large language models (LLMs) achieve near-perfect scores on medical licensing exams, these evaluations inadequately reflect the complexity and diversity of real-world clinical practice. We introduce MedHELM, an extensible evaluation …
View article: Endoscopic management of active arterial bleeding in walled-off necrosis collection
Endoscopic management of active arterial bleeding in walled-off necrosis collection Open
This case portrays successful endoscopic therapy for bleeding within a WON cavity. Normally, bleeding after placement of a LAMS is managed by interventional radiology. However, endoscopic therapy should be considered when imaging does not …
View article: Creating more viable safety recommendations in accident investigation by revising the human factors intervention matrix (HFIX)
Creating more viable safety recommendations in accident investigation by revising the human factors intervention matrix (HFIX) Open
View article: Differences in natriuretic peptide response in self-identified white and black individuals: a physiological clinical trial
Differences in natriuretic peptide response in self-identified white and black individuals: a physiological clinical trial Open
View article: Genome-Wide Identification of the GRAS Transcription Factor Family in Medicago ruthenica and Expression Analysis Under Drought Stress
Genome-Wide Identification of the GRAS Transcription Factor Family in Medicago ruthenica and Expression Analysis Under Drought Stress Open
The GRAS gene family encodes a group of plant-specific transcription factors essential for regulating plant growth, development and stress responses. While the GRAS gene family has been extensively studied in various plant species, a compr…
View article: Cost-Effectiveness of a Polypill for Cardiovascular Disease Prevention in an Underserved Population
Cost-Effectiveness of a Polypill for Cardiovascular Disease Prevention in an Underserved Population Open
Importance The Southern Community Cohort Study (SCCS) Polypill Trial showed that a cardiovascular polypill (a single pill containing a statin and 3 half-standard dose antihypertensive medications) effectively controls cardiovascular diseas…
View article: Predicting Major Stock Price Declines with Fundamentals: A Machine Learning Approach
Predicting Major Stock Price Declines with Fundamentals: A Machine Learning Approach Open
View article: From Turing Test to Chinese Room Argument: How to Apply Artificial Intelligence in Aviation
From Turing Test to Chinese Room Argument: How to Apply Artificial Intelligence in Aviation Open
View article: Predicting Major Stock Price Declines with Fundamentals: A Machine Learning Approach
Predicting Major Stock Price Declines with Fundamentals: A Machine Learning Approach Open
View article: High-Throughput Detection of Risk Factors to Sudden Cardiac Arrest in Youth Athletes: A Smartwatch-Based Screening Platform
High-Throughput Detection of Risk Factors to Sudden Cardiac Arrest in Youth Athletes: A Smartwatch-Based Screening Platform Open
Sudden Cardiac Arrest (SCA) is the leading cause of death among athletes of all age levels worldwide. Current prescreening methods for cardiac risk factors are largely ineffective, and implementing the International Olympic Committee recom…
View article: Pixtral 12B
Pixtral 12B Open
We introduce Pixtral-12B, a 12--billion-parameter multimodal language model. Pixtral-12B is trained to understand both natural images and documents, achieving leading performance on various multimodal benchmarks, surpassing a number of lar…
View article: Proteogenomic analysis integrated with electronic health records data reveals disease-associated variants in Black Americans
Proteogenomic analysis integrated with electronic health records data reveals disease-associated variants in Black Americans Open
BACKGROUNDMost GWAS of plasma proteomics have focused on White individuals of European ancestry, limiting biological insight from other ancestry-enriched protein quantitative loci (pQTL).METHODSWe conducted a discovery GWAS of approximatel…
View article: The subcutaneous adipose transcriptome identifies a molecular signature of insulin resistance shared with visceral adipose
The subcutaneous adipose transcriptome identifies a molecular signature of insulin resistance shared with visceral adipose Open
Objective The objective of this study was to identify the transcriptional landscape of insulin resistance (IR) in subcutaneous adipose tissue (SAT) in humans across the spectrum of obesity. Methods We used SAT RNA sequencing in 220 individ…
View article: Human adipose tissue expression of uncoupling protein 1 in response to intravenous administration of B‐type natriuretic peptide hormone: Results from a randomized controlled crossover study
Human adipose tissue expression of uncoupling protein 1 in response to intravenous administration of B‐type natriuretic peptide hormone: Results from a randomized controlled crossover study Open
Obesity is associated with an increased risk of cardiovascular and metabolic diseases. Despite surgical and pharmacological approaches to reduce weight, limitations due to contraindications, adverse effects, and lack of durable efficacy ne…
View article: Genomic and Transcriptomic Landscape of RET Wild-Type Medullary Thyroid Cancer and Potential Use of Mitogen-Activated Protein Kinase-Targeted Therapy
Genomic and Transcriptomic Landscape of RET Wild-Type Medullary Thyroid Cancer and Potential Use of Mitogen-Activated Protein Kinase-Targeted Therapy Open
BACKGROUND: About 75% of medullary thyroid cancers (MTCs) are sporadic with 45% to 70% being driven by a RET mutation. Selpercatinib is an approved treatment for RET-mutated (mut RET ) MTC; however, treatments are needed for wild-type RET …
View article: Correlates of Plasma NT‐proBNP/Cyclic GMP Ratio in Heart Failure With Preserved Ejection Fraction: An Analysis of the RELAX Trial
Correlates of Plasma NT‐proBNP/Cyclic GMP Ratio in Heart Failure With Preserved Ejection Fraction: An Analysis of the RELAX Trial Open
Background Phosphodiesterases degrade cyclic GMP (cGMP), the second messenger that mediates the cardioprotective effects of natriuretic peptides. High natriuretic peptide/cGMP ratio may reflect, in part, phosphodiesterase activity. Correla…
View article: Rift Valley Fever virus M and L genome segment detection: a comparison of field-deployable reverse transcription insulated isothermal PCR (RT-iiPCR) and laboratory-based multiplex reverse transcription real-time PCR
Rift Valley Fever virus M and L genome segment detection: a comparison of field-deployable reverse transcription insulated isothermal PCR (RT-iiPCR) and laboratory-based multiplex reverse transcription real-time PCR Open
Rift Valley Fever phlebovirus (RVFV) is a mosquito-borne zoonotic pathogen that causes major agricultural and public health problems in Africa and the Arabian Peninsula. It is considered a potential agro-bioterrorism agent for which limite…
View article: Mixtral of Experts
Mixtral of Experts Open
We introduce Mixtral 8x7B, a Sparse Mixture of Experts (SMoE) language model. Mixtral has the same architecture as Mistral 7B, with the difference that each layer is composed of 8 feedforward blocks (i.e. experts). For every token, at each…
View article: Helping Cancer Patients to Choose the Best Treatment: Towards Automated Data-Driven and Personalized Information Presentation of Cancer Treatment Options
Helping Cancer Patients to Choose the Best Treatment: Towards Automated Data-Driven and Personalized Information Presentation of Cancer Treatment Options Open
When a person is diagnosed with cancer, difficult decisions about treatments need to be made. In this chapter, we describe an interdisciplinary research project which aims to automatically generate personalized descriptions of treatment op…
View article: Metabolite Signature of Life’s Essential 8 and Risk of Coronary Heart Disease Among Low-Income Black and White Americans
Metabolite Signature of Life’s Essential 8 and Risk of Coronary Heart Disease Among Low-Income Black and White Americans Open
Background: Life’s essential 8 (LE8) is a comprehensive construct of cardiovascular health. Yet, little is known about the LE8 score, its metabolic correlates, and their predictive implications among Black Americans and low-income individu…
View article: Effect of Dietary Sodium on Blood Pressure
Effect of Dietary Sodium on Blood Pressure Open
Importance Dietary sodium recommendations are debated partly due to variable blood pressure (BP) response to sodium intake. Furthermore, the BP effect of dietary sodium among individuals taking antihypertensive medications is understudied.…
View article: FinGPT: Large Generative Models for a Small Language
FinGPT: Large Generative Models for a Small Language Open
Large language models (LLMs) excel in many tasks in NLP and beyond, but most open models have very limited coverage of smaller languages and LLM work tends to focus on languages where nearly unlimited data is available for pretraining. In …
View article: Mistral 7B
Mistral 7B Open
We introduce Mistral 7B v0.1, a 7-billion-parameter language model engineered for superior performance and efficiency. Mistral 7B outperforms Llama 2 13B across all evaluated benchmarks, and Llama 1 34B in reasoning, mathematics, and code …
View article: Endoscopic submucosal dissection of neoplastic lesions of the colon: clinical application and techniques
Endoscopic submucosal dissection of neoplastic lesions of the colon: clinical application and techniques Open
Endoscopic submucosal dissection (ESD), first developed in Japan, is increasingly performed worldwide to allow en bloc removal of large lesions from the gastrointestinal tract. Colorectal ESD results in higher en bloc and R0 resection rate…
View article: BIOMARKERS OF CARDIOVASCULAR STRESS AND LEFT VENTRICULAR HYPERTROPHIC PATTERNS: CROSS-SECTIONAL RELATIONS AND PROGNOSTIC SIGNIFICANCE
BIOMARKERS OF CARDIOVASCULAR STRESS AND LEFT VENTRICULAR HYPERTROPHIC PATTERNS: CROSS-SECTIONAL RELATIONS AND PROGNOSTIC SIGNIFICANCE Open
View article: Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma
Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma Open
Although many novel gene-metabolite and gene-protein associations have been identified using high-throughput biochemical profiling, systematic studies that leverage human genetics to illuminate causal relationships between circulating prot…