Richard Twycross-Lewis
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View article: An observational human study investigating the effect of anabolic androgenic steroid use on the transcriptome of skeletal muscle and whole blood using RNA-Seq
An observational human study investigating the effect of anabolic androgenic steroid use on the transcriptome of skeletal muscle and whole blood using RNA-Seq Open
Background The effects of Anabolic Androgenic Steroids (AAS) are largely illustrated through Androgen Receptor induced gene transcription, yet RNA-Seq has yet to be conducted on human whole blood and skeletal muscle. Investigating the tran…
View article: The MMAAS Project: An Observational Human Study Investigating the Effect of Anabolic Androgenic Steroid Use on Gene Expression and the Molecular Mechanism of Muscle Memory
The MMAAS Project: An Observational Human Study Investigating the Effect of Anabolic Androgenic Steroid Use on Gene Expression and the Molecular Mechanism of Muscle Memory Open
Objective: It remains unknown whether myonuclei remain elevated post anabolic-androgenic steroid (AAS) usage in humans. Limited data exist on AAS-induced changes in gene expression. Design: Cross-sectional/longitudinal. Setting: University…
View article: Sport and exercise genomics: the FIMS 2019 consensus statement update
Sport and exercise genomics: the FIMS 2019 consensus statement update Open
Rapid advances in technologies in the field of genomics such as high throughput DNA sequencing, big data processing by machine learning algorithms and gene-editing techniques are expected to make precision medicine and gene-therapy a great…
View article: Anterior cruciate ligament deficiency: rotational instability in the transverse plane. A preliminary laboratory in vivo study
Anterior cruciate ligament deficiency: rotational instability in the transverse plane. A preliminary laboratory in vivo study Open
Background.Rotational instability is a major feature of anterior cruciate ligament (ACL) deficiency.Few biomechanical studies have focused on the transverse plane when assessing the function of the ACL.Objective.To analyse the biomechanics…
View article: Intended Hydration Strategies and Knowledge of Exercise-Associated Hyponatraemia in Marathon Runners: A Questionnaire-Based Study
Intended Hydration Strategies and Knowledge of Exercise-Associated Hyponatraemia in Marathon Runners: A Questionnaire-Based Study Open
Context: Exercise-associated hyponatremia (EAH) is a potentially fatal condition that can be prevented by avoiding excessive fluid intake. Running has become more popular in recent years, so it is important to assess the safety of runners'…
View article: Testing Gait with Ankle-Foot Orthoses in Children with Cerebral Palsy by Using Functional Mixed-Effects Analysis of Variance
Testing Gait with Ankle-Foot Orthoses in Children with Cerebral Palsy by Using Functional Mixed-Effects Analysis of Variance Open
Existing statistical methods extract insufficient information from 3-dimensional gait data, rendering clinical interpretation of impaired movement patterns sub-optimal. We propose an alternative approach based on functional data analysis t…