Rick Liao
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View article: Backpack-mediated anti-inflammatory macrophage cell therapy for the treatment of traumatic brain injury
Backpack-mediated anti-inflammatory macrophage cell therapy for the treatment of traumatic brain injury Open
Traumatic brain injury (TBI) is a debilitating disease with no current therapies outside of acute clinical management. While acute, controlled inflammation is important for debris clearance and regeneration after injury, chronic, rampant i…
View article: Materials for Cell Surface Engineering
Materials for Cell Surface Engineering Open
Cell therapies are emerging as a promising new therapeutic modality in medicine, generating effective treatments for previously incurable diseases. Clinical success of cell therapies has energized the field of cellular engineering, spurrin…
View article: Alzheimer's and Parkinson's disease therapies in the clinic
Alzheimer's and Parkinson's disease therapies in the clinic Open
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent neurodegenerative diseases, affecting millions and costing billions each year in the United States alone. Despite tremendous progress in developing therapeutics t…
View article: Data management schema design for effective nanoparticle formulation for neurotherapeutics
Data management schema design for effective nanoparticle formulation for neurotherapeutics Open
Translation of nanotherapeutics from preclinical research to clinical application is difficult due to the complex and dynamic interaction space between the nanotherapeutic and the brain environment. To improve translation, increased insigh…
View article: Nanoparticle‐microglial interaction in the ischemic brain is modulated by injury duration and treatment
Nanoparticle‐microglial interaction in the ischemic brain is modulated by injury duration and treatment Open
Cerebral ischemia is a major cause of death in both neonates and adults, and currently has no cure. Nanotechnology represents one promising area of therapeutic development for cerebral ischemia due to the ability of nanoparticles to overco…
View article: Nanotherapeutic modulation of excitotoxicity and oxidative stress in acute brain injury
Nanotherapeutic modulation of excitotoxicity and oxidative stress in acute brain injury Open
Excitotoxicity is a primary pathological process that occurs during stroke, traumatic brain injury (TBI), and global brain ischemia such as perinatal asphyxia. Excitotoxicity is triggered by an overabundance of excitatory neurotransmitters…
View article: Determining dominant driving forces affecting controlled protein release from polymeric nanoparticles
Determining dominant driving forces affecting controlled protein release from polymeric nanoparticles Open
Enzymes play a critical role in many applications in biology and medicine as potential therapeutics. One specific area of interest is enzyme encapsulation in polymer nanostructures, which have applications in drug delivery and catalysis. A…
View article: Cover Image, Volume 9, Issue 2
Cover Image, Volume 9, Issue 2 Open
image The cover image, by Elizabeth Nance et al., is based on the Advanced Review Systems‐level thinking for nanoparticlemediated therapeutic delivery to neurological diseases , DOI: 10.1002/wnan.1422 .