Rick Wassing
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View article: P093 An algorithm for detecting local sleep during wakefulness in OSA
P093 An algorithm for detecting local sleep during wakefulness in OSA Open
Aim Local sleep during wakefulness is characterised by regional increased theta EEG activity and is associated with impaired cognitive performance in sleep deprived healthy subjects. Local sleep during wake may underlie neurobehavioral imp…
View article: P037 The effects of obstructive sleep apnea on cognition in schizophrenia
P037 The effects of obstructive sleep apnea on cognition in schizophrenia Open
Schizophrenia diagnosis relies primarily on clinical assessment, the ability to track cognitive function thus becomes an important tool in assessing symptom severity and the effects on daily function. As a result of medications, obstructiv…
View article: P067 Sleepiness upon awakening in non-restorative sleep, insomnia, and healthy controls
P067 Sleepiness upon awakening in non-restorative sleep, insomnia, and healthy controls Open
Introduction Non-restorative sleep (NRS) is characterised by unrefreshing sleep despite normal sleep duration, in contrast to insomnia disorder (ID) which is characterised with difficulty with sleep initiation and maintenance. Both disorde…
View article: O032 Neuromodulation to enhance sleep and cognition in healthy older adults
O032 Neuromodulation to enhance sleep and cognition in healthy older adults Open
Introduction Ageing is associated with cognitive decline and altered sleep architecture including greater sleep fragmentation. Alterations in brain oscillations such as decreased slow wave activity (SWA) and sleep spindles, which are impor…
View article: Acute Effects of Oral Cannabinoids on Sleep and High‐Density <scp>EEG</scp> in Insomnia: A Pilot Randomised Controlled Trial
Acute Effects of Oral Cannabinoids on Sleep and High‐Density <span>EEG</span> in Insomnia: A Pilot Randomised Controlled Trial Open
Cannabinoids, particularly Δ9‐tetrahydrocannabinol (THC) and cannabidiol (CBD), have gained popularity as alternative sleep aids; however, their effects on sleep architecture and next‐day function remain poorly understood. Here, in a pilot…
View article: 0123 The Effect of Obstructive Sleep Apnea on Sleep Neurophysiology and Cognition in Schizophrenia
0123 The Effect of Obstructive Sleep Apnea on Sleep Neurophysiology and Cognition in Schizophrenia Open
Introduction People living with schizophrenia are at high risk of developing obstructive sleep apnea (OSA). Sleep spindle deficits and impaired cognitive performance are commonly reported in schizophrenia, and in non-schizophrenia OSA popu…
View article: Moderately strong intraclass correlations between actigraphic and polysomnographic total sleep time and sleep efficiency in older adults with sleep disturbance
Moderately strong intraclass correlations between actigraphic and polysomnographic total sleep time and sleep efficiency in older adults with sleep disturbance Open
Objective To evaluate the reliability of the GeneActiv actigraphy device in measuring sleep parameters and compare its performance with polysomnography (PSG) in older adults with self-reported sleep disturbances. Methods This sub-study was…
View article: The effect of restricted and free-living conditions on light exposure and sleep in older adults
The effect of restricted and free-living conditions on light exposure and sleep in older adults Open
During the COVID-19 pandemic, studies reported that restricted living conditions were associated with worse subjective sleep quality. This effect might have been caused by reduced light exposure during lockdowns. We investigated light expo…
View article: Neural correlates of insomnia with depression and anxiety from a neuroimaging perspective: A systematic review
Neural correlates of insomnia with depression and anxiety from a neuroimaging perspective: A systematic review Open
Summary Insomnia affects a substantial proportion of the population and frequently co-occurs with mental illnesses including depression and anxiety. However, the neurobiological correlates of these disorders remain unclear. Here we review …
View article: P029 High-definition neurostimulation to enhance slow oscillations during sleep in obstructive sleep apnea: A randomised, single-blind, sham-controlled, crossover proof-of-concept protocol
P029 High-definition neurostimulation to enhance slow oscillations during sleep in obstructive sleep apnea: A randomised, single-blind, sham-controlled, crossover proof-of-concept protocol Open
Global and regional deficits in slow frequency EEG oscillations during non-rapid eye movement sleep, which have been reported in people with obstructive sleep apnea (OSA) may have detrimental consequences on cognitive performance. Current …
View article: O013 Sleep and overnight emotional memory in older adults with depression: A high-density EEG investigation
O013 Sleep and overnight emotional memory in older adults with depression: A high-density EEG investigation Open
Older adults with depression have a high incidence of sleep disturbance which is posited to be mechanistically involved in maladaptive overnight emotional memory consolidation. In older adults (≥ 50 years) with and without depression, we a…
View article: O073 The effect of blue-enriched light in older adults with sleep disturbance on sleep and daytime performance: A randomised, placebo-controlled crossover trial
O073 The effect of blue-enriched light in older adults with sleep disturbance on sleep and daytime performance: A randomised, placebo-controlled crossover trial Open
Introduction Light therapy is a non-pharmacological intervention for circadian and sleep disorders. However, there is limited evidence about the effect on electroencephalographic (EEG) sleep in older individuals with sleep disturbance. Met…
View article: Different heart rate variability profile during sleep in mid-later life adults with remitted early-onset versus late-onset depression
Different heart rate variability profile during sleep in mid-later life adults with remitted early-onset versus late-onset depression Open
The findings suggest differential autonomic profile for remitted early-onset and late-onset mid-later life adults during sleep stages and wake periods. The differences could potentially serve as peripheral biomarkers in conjunction with mo…
View article: Heart Rate Variability during Slow Wave Sleep is Linked to Resting‐state Functional Connectivity in the Central Autonomic Network among Older Adults ‘at‐risk’ of Dementia
Heart Rate Variability during Slow Wave Sleep is Linked to Resting‐state Functional Connectivity in the Central Autonomic Network among Older Adults ‘at‐risk’ of Dementia Open
Background Reduced heart rate variability (HRV) can be an early sign of autonomic dysfunction in neurodegenerative diseases, and may be related to brain dysfunction in the central autonomic network (CAN). As yet, such autonomic dysfunction…
View article: Differential Heart Rate Variability Profiles During Sleep in Older Adults with Remitted Early‐onset versus Late‐onset Depression
Differential Heart Rate Variability Profiles During Sleep in Older Adults with Remitted Early‐onset versus Late‐onset Depression Open
Background Sleep is a physiological state involving a dynamic autonomic profile that is ideal for detecting subtle changes in autonomic nervous system functioning. The current study sought to determine if heart rate variability (HRV) durin…
View article: Insomnia subtypes have differentiating deviations in brain structural connectivity
Insomnia subtypes have differentiating deviations in brain structural connectivity Open
Objective Insomnia disorder is the most common sleep disorder. A better understanding of insomnia-related deviations in the brain could inspire better treatment. Insufficiently recognized heterogeneity within the insomnia population could …
View article: The first‐night effect and the consistency of short sleep in insomnia disorder
The first‐night effect and the consistency of short sleep in insomnia disorder Open
Summary The nature and degree of objective sleep impairments in insomnia disorder remain unclear. This issue is complicated further by potential changes in sleep architecture on the first compared with subsequent nights in the laboratory. …
View article: From childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia
From childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia Open
Introduction A new line of insomnia research focuses on the developmental trajectories from early live stress to insomnia in adulthood. Adverse childhood experiences (ACE’s) might create a vulnerability for later maladaptive coping with di…
View article: Associations between signs of sleep bruxism and insomnia: A polysomnographic study
Associations between signs of sleep bruxism and insomnia: A polysomnographic study Open
Summary Sleep bruxism (SB) is a repetitive jaw‐muscle activity characterised by clenching or grinding of the teeth and/or by bracing or thrusting of the mandible. Sleep bruxism has been linked with insomnia symptoms. Moreover, it has been …
View article: Heart rate variability during slow wave sleep is linked to functional connectivity in the central autonomic network
Heart rate variability during slow wave sleep is linked to functional connectivity in the central autonomic network Open
Reduced heart rate variability can be an early sign of autonomic dysfunction in neurodegenerative diseases and may be related to brain dysfunction in the central autonomic network. As yet, such autonomic dysfunction has not been examined d…
View article: Insomnia disorder: State of the science and challenges for the future
Insomnia disorder: State of the science and challenges for the future Open
Summary Insomnia disorder comprises symptoms during night and day that strongly affect quality of life and wellbeing. Prolonged sleep latency, difficulties to maintain sleep and early morning wakening characterize sleep complaints, whereas…
View article: P120 The Relationship Between Sleep Architecture And Cognition In Late-Life Depression
P120 The Relationship Between Sleep Architecture And Cognition In Late-Life Depression Open
Introduction Depression in older people is associated with changes in sleep, however associations between sleep architecture and cognition have not yet been delineated. We examined sleep architecture in older people with and without depres…
View article: Insomnia subtypes characterised by objective sleep duration and NREM spectral power and the effect of acute sleep restriction: an exploratory analysis
Insomnia subtypes characterised by objective sleep duration and NREM spectral power and the effect of acute sleep restriction: an exploratory analysis Open
Insomnia disorder (ID) is a heterogeneous disorder with proposed subtypes based on objective sleep duration. We speculated that insomnia subtyping with additional power spectral analysis and measurement of response to acute sleep restricti…
View article: 033 The effect of sleep disturbance on cognition in late-life depression
033 The effect of sleep disturbance on cognition in late-life depression Open
Introduction Late-life depression is the most common psychiatric disorder in older adults and is associated with cognitive deficits, however, the role of sleep disturbance in cognitive deficits is poorly defined. In the current study we ai…
View article: ENIGMA‐Sleep: Challenges, opportunities, and the road map
ENIGMA‐Sleep: Challenges, opportunities, and the road map Open
Summary Neuroimaging and genetics studies have advanced our understanding of the neurobiology of sleep and its disorders. However, individual studies usually have limitations to identifying consistent and reproducible effects, including mo…
View article: Optimizing actigraphic estimates of polysomnographic sleep features in insomnia disorder
Optimizing actigraphic estimates of polysomnographic sleep features in insomnia disorder Open
Study Objectives Actigraphy is a useful tool for estimating sleep, but less accurately distinguishes sleep and wakefulness in patients with insomnia disorder (ID) than in good sleepers. Specific algorithm parameter settings have been sugge…