Rickesha Bell
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View article: A capsular polysaccharide from a healthy human microbiota member activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy
A capsular polysaccharide from a healthy human microbiota member activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy Open
View article: Draft genome of a human gut-derived <i>Blautia</i> sp. that ameliorates colitis and colitis-associated sociability deficits in mice
Draft genome of a human gut-derived <i>Blautia</i> sp. that ameliorates colitis and colitis-associated sociability deficits in mice Open
Blautia is a genus of anaerobic, gram-positive bacteria commonly found in mammalian gastrointestinal tracts. Yet, how variations among different Blautia strains can impact host health is poorly understood. We present a Blautia sp. genome i…
View article: Low-Iron Diet-Induced Fatty Liver Development Is Microbiota Dependent and Exacerbated by Loss of the Mitochondrial Iron Importer Mitoferrin2
Low-Iron Diet-Induced Fatty Liver Development Is Microbiota Dependent and Exacerbated by Loss of the Mitochondrial Iron Importer Mitoferrin2 Open
Iron deficiency is the number one nutritional problem worldwide. Iron uptake is regulated at the intestine and is highly influenced by the gut microbiome. Blood from the intestines drains directly into the liver, informing iron status and …
View article: Colitis reduces active social engagement in mice and is ameliorated by supplementation with human microbiota members
Colitis reduces active social engagement in mice and is ameliorated by supplementation with human microbiota members Open
Multiple neurological disorders are associated with gastrointestinal (GI) symptoms, including autism spectrum disorder (ASD). However, it is unclear whether GI distress itself can modify aspects of behavior. Here, we show that mice that ex…
View article: Clec12a tempers inflammation while restricting expansion of a colitogenic commensal
Clec12a tempers inflammation while restricting expansion of a colitogenic commensal Open
SUMMARY Regulation of the microbiota is critical to intestinal health yet the mechanisms employed by innate immunity remain unclear. Here we show that mice deficient in the C-Type-lectin receptor, Clec12a developed severe colitis, which wa…
View article: BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass
BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass Open
View article: A microbiota membrane disrupter disseminates to the pancreas and increases β-cell mass
A microbiota membrane disrupter disseminates to the pancreas and increases β-cell mass Open
Summary Microbiome dysbiosis is a feature of diabetes, but how microbial products influence insulin production is poorly understood. Here we report the mechanism of BefA, a microbiome-derived protein that increases proliferation of insulin…
View article: Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition
Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition Open
Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but are not considered canonical antigen-presenting cells, and the impact of IEC-MHC …
View article: Adaptive immunity induces mutualism between commensal eukaryotes
Adaptive immunity induces mutualism between commensal eukaryotes Open
View article: Thymic development of gut-microbiota-specific T cells
Thymic development of gut-microbiota-specific T cells Open
View article: Molecular patterns from a human gut-derived Lactobacillus strain suppress pathogenic infiltration of leukocytes into the central nervous system
Molecular patterns from a human gut-derived Lactobacillus strain suppress pathogenic infiltration of leukocytes into the central nervous system Open
View article: T cell–mediated regulation of the microbiota protects against obesity
T cell–mediated regulation of the microbiota protects against obesity Open
T cells help keep you lean The gut microbiota is a critical factor regulating mammalian metabolism. The host immune system, in turn, can shape the microbiome, in part via immunoglobulin A (IgA) antibodies. Petersen et al. report that mice …
View article: The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling
The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling Open
Symbiotic microbes impact the function and development of the central nervous system (CNS); however, little is known about the contribution of the microbiota during viral-induced neurologic damage. We identify that commensals aid in host d…
View article: Author response: The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling
Author response: The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Symbiotic microbes impact the…
View article: Latency for facultative expression of male-typical courtship behaviour by female bluehead wrasses depends on social rank: The ‘priming/gating’ hypothesis
Latency for facultative expression of male-typical courtship behaviour by female bluehead wrasses depends on social rank: The ‘priming/gating’ hypothesis Open
While socially-controlled sex transformation in fishes is well established, the underlying mechanisms are not well understood. Particularly enigmatic is behavioural transformation, in which fish can rapidly switch from exhibiting female to…
View article: Latency for facultative expression of male-typical courtship behaviour by female bluehead wrasses depends on social rank: The ‘priming/gating’ hypothesis.
Latency for facultative expression of male-typical courtship behaviour by female bluehead wrasses depends on social rank: The ‘priming/gating’ hypothesis. Open
While socially-controlled sex transformation in fishes is well established, the underlying mechanisms are not well understood. Particularly enigmatic is behavioural transformation, in which fish can rapidly switch from exhibiting female to…
View article: 2018 JEB Wrasse Priming Gating Data
2018 JEB Wrasse Priming Gating Data Open
While socially-controlled sex transformation in fishes is well established, the underlying mechanisms are not well understood. Particularly enigmatic is behavioural transformation, in which fish can rapidly switch from exhibiting female to…
View article: Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor
Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor Open
Significance Little is known about the molecular mechanisms by which the microbiota influences T-cell responses. We have determined that a secreted protein, Erdr1, is highly upregulated in germfree T cells and that microbial products can s…
View article: A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice
A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice Open
Saccharomyces cerevisiae induces purine metabolism in mouse intestinal epithelia, resulting in an exacerbation of colitis.
View article: MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection
MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection Open
The presentation of protein antigens on the cell surface by major histocompatibility complex (MHC) molecules coordinates vertebrate adaptive immune responses, thereby mediating susceptibility to a variety of autoimmune and infectious disea…