Ricky Cain
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View article: Discovery of Novel UDP- <i>N</i> -Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against <i>Pseudomonas aeruginosa</i>
Discovery of Novel UDP- <i>N</i> -Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against <i>Pseudomonas aeruginosa</i> Open
This study describes a novel series of UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitors that was identified through affinity-mediated selection from a DNA-encoded compound library. The original hit was a selective inhibitor…
View article: Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients
Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients Open
View article: Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli
Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli Open
Resistance to β-lactam antibacterials, importantly via production of β-lactamases, threatens their widespread use. Bicyclic boronates show promise as clinically useful, dual-action inhibitors of both serine- (SBL) and metallo- (MBL) β-lact…
View article: Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients
Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients Open
Novel antimicrobials are urgently needed to combat the increasing occurrence of drug-resistant bacteria and to overcome the inherent difficulties in treating biofilm-associated infections. Research into natural antimicrobials could provide…
View article: Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase
Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase Open
Aminoacyl-tRNA synthetases are ubiquitous and essential enzymes for protein synthesis and also a variety of other metabolic processes, especially in bacterial species. Bacterial aminoacyl-tRNA synthetases represent attractive and validated…
View article: Profiling interactions of vaborbactam with metallo-β-lactamases
Profiling interactions of vaborbactam with metallo-β-lactamases Open
View article: Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase
Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase Open
Aminoacyl-tRNA synthetases are ubiquitous and essential enzymes for protein synthesis and also a variety of other metabolic processes, especially in bacterial species. Bacterial aminoacyl-tRNA synthetases represent attractive and validated…
View article: Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates
Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates Open
View article: In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors
In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors Open
Zinc ion-dependent β-lactamases (MBLs) catalyze the hydrolysis of almost all β-lactam antibiotics and resist the action of clinically available β-lactamase inhibitors. We report how application of in silico fragment-based molecular design …
View article: Structural/mechanistic insights into the efficacy of nonclassical β‐lactamase inhibitors against extensively drug resistant <i>Stenotrophomonas maltophilia</i> clinical isolates
Structural/mechanistic insights into the efficacy of nonclassical β‐lactamase inhibitors against extensively drug resistant <i>Stenotrophomonas maltophilia</i> clinical isolates Open
Summary Clavulanic acid and avibactam are clinically deployed serine β‐lactamase inhibitors, important as a defence against antibacterial resistance. Bicyclic boronates are recently discovered inhibitors of serine and some metallo β‐lactam…
View article: A chemical genomics approach to drug reprofiling in oncology: Antipsychotic drug risperidone as a potential adenocarcinoma treatment
A chemical genomics approach to drug reprofiling in oncology: Antipsychotic drug risperidone as a potential adenocarcinoma treatment Open
View article: Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates
Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates Open
View article: Design and synthesis of metallo-β-lactamase inhibitors
Design and synthesis of metallo-β-lactamase inhibitors Open
Bacterial resistance is a continuously evolving threat to our most common antibiotics; the β-lactams. Most recently, the production of β-lactamase enzymes by bacteria rendered many of our current antibiotics unusable threatening to plunge …