Ricky R. Lareu
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View article: Chronic metabolic effects of novel gut-oriented small-molecule GPR119 agonists in diet-induced obese mice
Chronic metabolic effects of novel gut-oriented small-molecule GPR119 agonists in diet-induced obese mice Open
The pharmacological activation of G-protein coupled receptor-119 (GPR119) modulates glucose, energy, and hepatic lipid homeostasis in type-2 diabetes (T2D). We developed synthetic small-molecule GPR119 agonists targeting gastrointestinal r…
View article: Unlocking the Therapeutic Potential of Ellagic Acid for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis
Unlocking the Therapeutic Potential of Ellagic Acid for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis Open
Obesity is in epidemic proportions in many parts of the world, contributing to increasing rates of non-alcoholic fatty liver disease (NAFLD). NAFLD represents a range of conditions from the initial stage of fatty liver to non-alcoholic ste…
View article: The Effectiveness of Evidence-Based Teaching Practices in Biomedical Sciences on Students’ Learning Experience: A Systematic Literature Review
The Effectiveness of Evidence-Based Teaching Practices in Biomedical Sciences on Students’ Learning Experience: A Systematic Literature Review Open
The traditional didactic approach to teaching in biomedical sciences falls short of providing students with the 21st century competencies necessary to meet the socioeconomic demands placed upon them. Tertiary biomedical science educators h…
View article: DETERMINATION OF CELL TYPE AND HAEMOCYTE MORPHOMETRIC CHARACTERISTICS OF WESTERN AUSTRALIA FRESHWATER CRAYFISH (Cherax cainii) AT DIFFERENT TEMPERATURES IN VITRO
DETERMINATION OF CELL TYPE AND HAEMOCYTE MORPHOMETRIC CHARACTERISTICS OF WESTERN AUSTRALIA FRESHWATER CRAYFISH (Cherax cainii) AT DIFFERENT TEMPERATURES IN VITRO Open
The purpose of this study was to identify and morphologically characterize the hemocyte cell types of freshwater crayfish, Cherax cainii. In addition to morphological observations using a light microscope (LM) and electron transmission mic…
View article: A sequence symmetry analysis of the interrelationships between statins, diabetes and skin infections
A sequence symmetry analysis of the interrelationships between statins, diabetes and skin infections Open
Aims To determine statins' impact on skin infection risk in view of conflicting literature: that statins may reduce infection risk, but are also associated with diabetes mellitus, a risk factor for skin and soft tissue infections (SSTIs). …
View article: Effect of Statins on Sepsis Outcome in a Population-Based Cohort Study
Effect of Statins on Sepsis Outcome in a Population-Based Cohort Study Open
View article: Statin Use Associated With a Decreased Risk of Community-Acquired Staphylococcus aureus Bacteremia
Statin Use Associated With a Decreased Risk of Community-Acquired Staphylococcus aureus Bacteremia Open
View article: Statins: antimicrobial resistance breakers or makers?
Statins: antimicrobial resistance breakers or makers? Open
Introduction The repurposing of non-antibiotic drugs as adjuvant antibiotics may help break antimicrobial resistance (AMR). Statins are commonly prescribed worldwide to lower cholesterol. They also possess qualities of AMR “breakers”, name…
View article: Peer Review #2 of "Statins: antimicrobial resistance breakers or makers? (v0.1)"
Peer Review #2 of "Statins: antimicrobial resistance breakers or makers? (v0.1)" Open
CONCLUSIONSimvastatin appears to be the most suitable statin for repurposing as a novel adjuvant antibiotic.Current evidence better supports statins as potential AMR breakers, but their role as plausible AMR makers cannot be excluded.Eluci…
View article: Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism
Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism Open
This study demonstrates that statin therapy drives a profound remodelling of the gut microbiota, hepatic gene deregulation and metabolic alterations in mice through a PXR-dependent mechanism. Since the demonstrated importance of the intest…
View article: Additional file 1: Figure S1. of Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism
Additional file 1: Figure S1. of Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism Open
Effect of statin therapy and diet on body weight and glucose metabolism. Figure S2. Changes in the gut microbiome composition in response to statins of mice fed with ND. Figure S3. Changes in the gut microbiome composition in response to h…