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View article: Vaccine Hesitancy: A Ticking Time Bomb
Vaccine Hesitancy: A Ticking Time Bomb Open
The rise in cases of vaccine hesitancy is becoming a global threat to tackling emerging public health challenge such as pandemics. This study aims to investigate the prevalence and underlying factors fuelling vaccine hesitancy within Niger…
View article: Long COVID among the first three waves of COVID-19 in Japan: a multicentre cohort study
Long COVID among the first three waves of COVID-19 in Japan: a multicentre cohort study Open
Objectives Severe acute respiratory syndrome coronavirus 2 significantly impacts Japan with a high number of infections and deaths reported. Long coronavirus disease (COVID) characterised by persistent symptoms after COVID-19 has gained re…
View article: Quantitative live-cell imaging of secretion activity reveals dynamic immune responses
Quantitative live-cell imaging of secretion activity reveals dynamic immune responses Open
View article: Clinical characteristics of allergic bronchopulmonary mycosis caused by <i>Schizophyllum commune</i>
Clinical characteristics of allergic bronchopulmonary mycosis caused by <i>Schizophyllum commune</i> Open
Background Allergic bronchopulmonary mycosis (ABPM) is an allergic disease caused by type I and type III hypersensitivity to environmental fungi. Schizophyllum commune , a basidiomycete fungus, is one of the most common fungi that causes n…
View article: Longitudinal long COVID symptoms in Japanese patients after COVID-19 vaccinations
Longitudinal long COVID symptoms in Japanese patients after COVID-19 vaccinations Open
View article: Differences among epitopes recognized by neutralizing antibodies induced by SARS-CoV-2 infection or COVID-19 vaccination
Differences among epitopes recognized by neutralizing antibodies induced by SARS-CoV-2 infection or COVID-19 vaccination Open
SARS-CoV-2 has gradually acquired amino acid substitutions in its S protein that reduce the potency of neutralizing antibodies, leading to decreased vaccine efficacy. Here, we attempted to obtain mutant viruses by passaging SARS-CoV-2 in t…
View article: Propensity-Score Matched Analysis of the Effectiveness of Baricitinib in Patients With Coronavirus Disease 2019 (COVID-19) Using Nationwide Real-World Data: An Observational Matched Cohort Study From the Japan COVID-19 Task Force
Propensity-Score Matched Analysis of the Effectiveness of Baricitinib in Patients With Coronavirus Disease 2019 (COVID-19) Using Nationwide Real-World Data: An Observational Matched Cohort Study From the Japan COVID-19 Task Force Open
Background To determine the effectiveness of baricitinib in patients with coronavirus disease 2019 (COVID-19), investigate whether baricitinib prevents the need for invasive mechanical ventilation and identify patient subgroups that would …
View article: Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s
Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s Open
Group 2 innate lymphoid cells (ILC2s) produce large amounts of type 2 cytokines including interleukin-5 (IL-5) and IL-13 in response to various stimuli, causing allergic and eosinophilic diseases. However, the cell-intrinsic regulatory mec…
View article: Multi-omics of NET formation and correlations with CNDP1, PSPB, and L-cystine levels in severe and mild COVID-19 infections
Multi-omics of NET formation and correlations with CNDP1, PSPB, and L-cystine levels in severe and mild COVID-19 infections Open
View article: Upregulation of IL-4 receptor signaling pathway in circulating ILC2s from asthma patients
Upregulation of IL-4 receptor signaling pathway in circulating ILC2s from asthma patients Open
View article: Multi-omics Characterization of Neutrophil Extracellular Trap Formation in Severe and Mild COVID-19 Infections
Multi-omics Characterization of Neutrophil Extracellular Trap Formation in Severe and Mild COVID-19 Infections Open
Summary The detailed mechanisms of COVID-19 infection pathology remain poorly understood. To improve our understanding of SARS-CoV-2 pathology, we performed a multi-omics analysis of an immunologically naïve SARS-CoV-2 clinical cohort from…
View article: Comprehensive Analysis of Long COVID in a Japanese Nationwide Prospective Cohort Study
Comprehensive Analysis of Long COVID in a Japanese Nationwide Prospective Cohort Study Open
View article: Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol
Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol Open
Introduction The rapid spread of COVID-19 posed a global burden. Substantial number of people died of the disease in the acute phase of infection. In addition, a significant proportion of patients have been reported to suffer from post-acu…
View article: Characterization of a new SARS-CoV-2 variant that emerged in Brazil
Characterization of a new SARS-CoV-2 variant that emerged in Brazil Open
Significance Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are of concern, with the P.1 variants dominating in Brazil. Brazil is now seeing a record number of deaths. Here, we report that the pathogenicity in hamste…
View article: Clinical Efficacy and Adverse Event of Remdesivir Treatment in Seven COVID-19 Cases with Respiratory Failure
Clinical Efficacy and Adverse Event of Remdesivir Treatment in Seven COVID-19 Cases with Respiratory Failure Open
A preliminary report from a global study showed that remdesivir, a nucleoside analog pro-drug that was originally developed as a therapeutic drug against Ebola virus, may exert clinical efficacy in cases of COVID-19, by shortening the time…
View article: Longitudinal antibody repertoire in “mild” versus “severe” COVID-19 patients reveals immune markers associated with disease severity and resolution
Longitudinal antibody repertoire in “mild” versus “severe” COVID-19 patients reveals immune markers associated with disease severity and resolution Open
SARS-CoV-2–induced human antibody repertoire in patients with COVID-19 reveals immune markers of disease severity and recovery.
View article: Antibody titers against SARS-CoV-2 decline, but do not disappear for several months
Antibody titers against SARS-CoV-2 decline, but do not disappear for several months Open
The Japan Agency for Medical Research and Development and the National Institutes of Allergy and Infectious Diseases.
View article: The Effectiveness of Nasal Airway Stent Therapy for the Treatment of Mild-to-Moderate Obstructive Sleep Apnea Syndrome
The Effectiveness of Nasal Airway Stent Therapy for the Treatment of Mild-to-Moderate Obstructive Sleep Apnea Syndrome Open
Background: Patients with obstructive sleep apnea syndrome (OSAS) experience excessive daytime sleepiness and insomnia and they are at risk of developing cardiovascular disease and stroke. Continuous positive airway pressure …
View article: Comparison of Rapid Antigen Tests for COVID-19
Comparison of Rapid Antigen Tests for COVID-19 Open
Reverse transcription-quantitative PCR (RT-qPCR)-based tests are widely used to diagnose coronavirus disease 2019 (COVID-19). As a result that these tests cannot be done in local clinics where RT-qPCR testing capability is lacking, rapid a…
View article: Clinical Interpretations and Therapeutic Significance of Isolating Aspergillus Species from Respiratory Specimens
Clinical Interpretations and Therapeutic Significance of Isolating Aspergillus Species from Respiratory Specimens Open
View article: Repetitive instructions at short intervals contribute to the improvement of inhalation technique
Repetitive instructions at short intervals contribute to the improvement of inhalation technique Open
Repetitive instructions at shorter intervals may be helpful for patients to develop and maintain an improved inhalation technique.
View article: Novel segmentation method using a self-organizing neural network for spectral CT
Novel segmentation method using a self-organizing neural network for spectral CT Open
Poster: ECR 2020 / C-08185 / Novel segmentation method using a self-organizing neural network for spectral CT by: A. Yoneyama 1, R. Baba2, M. Kawamoto3, T.-T. Lwin4; 1Tosu, Saga/JP, 2Tokyo/JP, 3Tosu/JP, 4Sagamihara/JP
View article: Construction of a system using a deep learning algorithm to count cell numbers in nanoliter wells for viable single-cell experiments
Construction of a system using a deep learning algorithm to count cell numbers in nanoliter wells for viable single-cell experiments Open
For single-cell experiments, it is important to accurately count the number of viable cells in a nanoliter well. We used a deep learning-based convolutional neural network (CNN) on a large amount of digital data obtained as microscopic ima…