Ryo Takeuchi
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View article: Genome-wide off-target assessment on the arginine vasotocin receptor V1a2 knockout Scomber japonicus (chub mackerel)
Genome-wide off-target assessment on the arginine vasotocin receptor V1a2 knockout Scomber japonicus (chub mackerel) Open
Background In recent decades, genome-edited fish production is gaining momentum among aquaculturists, but uncertainties about off-target mutations is a major concern for commercialization of genome-edited fish products. Recently, a knockou…
View article: First-Principles Study of Stable Local Structures and Mg Insertion/Detachment Mechanism During Charge–Discharge of Spinel Mg(Co, Ni, Mn, Al)<sub><b>2</b></sub>O<sub><b>4</b></sub> as Cathode Materials of Magnesium Secondary Batteries
First-Principles Study of Stable Local Structures and Mg Insertion/Detachment Mechanism During Charge–Discharge of Spinel Mg(Co, Ni, Mn, Al)<sub><b>2</b></sub>O<sub><b>4</b></sub> as Cathode Materials of Magnesium Secondary Batteries Open
View article: Multiplex Gene Editing Suppresses Random Integration of Hepatitis B Virus DNA in Chronically Infected Liver
Multiplex Gene Editing Suppresses Random Integration of Hepatitis B Virus DNA in Chronically Infected Liver Open
Gene editing technologies have opened the possibility of directly targeting viral DNA in therapeutic applications. In chronically infected hepatocytes with hepatitis B virus (HBV), covalently closed circular DNA (cccDNA) serves as the mast…
View article: Serum factors create species-specific barriers to hepatic gene transfer by lipid nanoparticles in liver-humanized mice
Serum factors create species-specific barriers to hepatic gene transfer by lipid nanoparticles in liver-humanized mice Open
View article: Axial Length Stabilization or Reduction in over 40% of Patients Wearing Extended Depth-of-Focus Contact Lenses
Axial Length Stabilization or Reduction in over 40% of Patients Wearing Extended Depth-of-Focus Contact Lenses Open
Background/Objectives: Preceding studies have reported the efficacy of multifocal contact lenses (MFCLs) in slowing myopia progression. Recently, a novel type of MFCL, i.e., extended depth-of-focus (EDOF) contact lens (CL), was designed. H…
View article: Iridium-Catalyzed Regioselective Hydroalkylation of Terminal Allenes with Malonic Amides
Iridium-Catalyzed Regioselective Hydroalkylation of Terminal Allenes with Malonic Amides Open
View article: Addendum to: Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases
Addendum to: Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases Open
View article: Investigation of Stable Structures and Electronic States of Spinel-Structured MgCo<sub>2–<i>z</i></sub>Ni<sub>0.5</sub>MnAl<sub><i>z</i></sub>O<sub>4</sub> (<i>Z</i> = 0, 0.3) as Cathode Materials for Magnesium Rechargeable Batteries Using First-Principles Calculations
Investigation of Stable Structures and Electronic States of Spinel-Structured MgCo<sub>2–<i>z</i></sub>Ni<sub>0.5</sub>MnAl<sub><i>z</i></sub>O<sub>4</sub> (<i>Z</i> = 0, 0.3) as Cathode Materials for Magnesium Rechargeable Batteries Using First-Principles Calculations Open
The stable structures of pristine spinel MgCo2–zNi0.5MnAlzO4 (z = 0, 0.3) are elucidated by first-principles calculations. Electron-density and projected density of states (PDOS) calculations are performed for the z = 0 and 0.3 compounds. …
View article: Protocol for the transformation and engineering of edible algae Arthrospira platensis to generate heterologous protein-expressing strains
Protocol for the transformation and engineering of edible algae Arthrospira platensis to generate heterologous protein-expressing strains Open
Here, we present a protocol for harnessing the natural transformability of the edible algae Arthrospira platensis (common name: spirulina) to generate strains that express heterologous proteins. We describe the preparation of plasmids and …
View article: CCDC 2190178: Experimental Crystal Structure Determination
CCDC 2190178: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2190177: Experimental Crystal Structure Determination
CCDC 2190177: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Author Correction: Development of spirulina for the manufacture and oral delivery of protein therapeutics
Author Correction: Development of spirulina for the manufacture and oral delivery of protein therapeutics Open
View article: Development of spirulina for the manufacture and oral delivery of protein therapeutics
Development of spirulina for the manufacture and oral delivery of protein therapeutics Open
View article: Improvement in Long-Term Stability of Field Effect Transistor Biosensor in Aqueous Environments Using a Combination of Silane and Reduced Graphene Oxide Coating
Improvement in Long-Term Stability of Field Effect Transistor Biosensor in Aqueous Environments Using a Combination of Silane and Reduced Graphene Oxide Coating Open
View article: Effects of size and position of an unconnected aluminum electrode on bipolar anodization in an AC electric field
Effects of size and position of an unconnected aluminum electrode on bipolar anodization in an AC electric field Open
View article: CCDC 2080098: Experimental Crystal Structure Determination
CCDC 2080098: Experimental Crystal Structure Determination Open
View article: CCDC 2080099: Experimental Crystal Structure Determination
CCDC 2080099: Experimental Crystal Structure Determination Open
View article: Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases
Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases Open
Streptococcus pyogenes (Spy) Cas9 has potential as a component of gene therapeutics for incurable diseases. One of its limitations is its large size, which impedes its formulation and delivery in therapeutic applications. Smaller Cas9s are…
View article: DC bipolar anodization of aluminum: Wider anode area than expected on the bipolar electrodes
DC bipolar anodization of aluminum: Wider anode area than expected on the bipolar electrodes Open
View article: Expression and manufacturing of protein therapeutics in spirulina
Expression and manufacturing of protein therapeutics in spirulina Open
Arthrospira platensis (commonly known as spirulina) is a photosynthetic cyanobacterium 1 . It is a highly nutritious food that has been consumed for decades in the US, and even longer by indigenous cultures 2 . Its widespread use as a safe…
View article: Unusual surfaces with structural gradients: Investigation of potential gradients on bipolar electrodes during bipolar anodization of aluminum
Unusual surfaces with structural gradients: Investigation of potential gradients on bipolar electrodes during bipolar anodization of aluminum Open
View article: Reaction of Aminomalononitrile and Benzylic Compounds as a Plausible Route to Phenylalanine
Reaction of Aminomalononitrile and Benzylic Compounds as a Plausible Route to Phenylalanine Open
As a possible route to phenylalanine, reaction of aminomalononitrile with benzylic compounds was studied. 2-Benzyl-2-aminomalononitrile (3) was obtained in a good yield when aminomalononitrile p-toluenesulfonate (1) was treated with benzyl…
View article: Synthesis of Anthraquinones by Iridium-Catalyzed [2 + 2 + 2] Cycloaddition of a 1,2-Bis(propiolyl)benzene Derivative with Alkynes
Synthesis of Anthraquinones by Iridium-Catalyzed [2 + 2 + 2] Cycloaddition of a 1,2-Bis(propiolyl)benzene Derivative with Alkynes Open
[2 + 2 + 2] cycloaddition of a 1,2-bis(propiolyl)benzene derivative with terminal and internal alkynes takes place in the presence of [Ir(cod)Cl]2 (cod = 1,5-cyclooctadiene) combined with bis(diphenylphosphino)ethane (DPPE) to give anthraq…
View article: Full Automatic Wide Range Fire Extinguish System for Residential Use
Full Automatic Wide Range Fire Extinguish System for Residential Use Open
We have continued to improve on previous studies. It is an improvement of the system which detects the fire automatically and performs the initial extinguishment. This system operates attached to the digestive device of existing products. …
View article: Full Automatic Fire Extinguish System for Residential Use
Full Automatic Fire Extinguish System for Residential Use Open
We are continuing to improve followed previous from three years ago. It fires detected automatically, and improvement of residential systems for fire-fighters remotely. The system, it is possible to build an automatic fire extinguishing sy…
View article: Iridium-Catalyzed Enantioselective Allylic Substitution
Iridium-Catalyzed Enantioselective Allylic Substitution Open
Regio- and stereoselective allylic substitution is an important tool for the synthesis of complex organic molecules. Due to the high branched-product selectivity, iridium gives a new opportunity in enantioselective synthesis. Iridium-catal…
View article: Back Cover: Iridium‐Catalyzed [2+2+2] Cycloaddition of α,ω‐Diynes with Cyanamides (Adv. Synth. Catal. 18/2015)
Back Cover: Iridium‐Catalyzed [2+2+2] Cycloaddition of α,ω‐Diynes with Cyanamides (Adv. Synth. Catal. 18/2015) Open
The back cover picture, provided by Ryo Takeuchi and co-workers, illustrates the iridium-catalyzed [2+2+2] cycloaddition of α,ω-diynes with cyanamides. The iridium catalyst is efficient for the atom-economical synthesis of multi-substitute…
View article: Erratum: Corrigendum: Biocontainment of genetically modified organisms by synthetic protein design
Erratum: Corrigendum: Biocontainment of genetically modified organisms by synthetic protein design Open
View article: POSTER SESSION 3
POSTER SESSION 3 Open
Introduction: The clinical and pathophysiological heterogeneity variety of risk factors predisposing to AF is large.Better understanding of the phenotypic heterogeneity of those at risk for AF may allow better risk prediction.Latent class …
View article: Biocontainment of genetically modified organisms by synthetic protein design
Biocontainment of genetically modified organisms by synthetic protein design Open