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View article: Zn containing mesoporous bioglasses with enhanced textural and antibacterial properties produced by three modifications of the sol-gel method
Zn containing mesoporous bioglasses with enhanced textural and antibacterial properties produced by three modifications of the sol-gel method Open
Mesoporous bioactive glasses (MBGs) have potential applications in bone tissue regeneration around tooth implant and local drug delivery. Small amounts of zinc added to their composition could additionally provide antibacterial and ossteoi…
View article: Development of CPE/ssDNA-Based Electrochemical Sensor for the Detection of Leucine to Assess Soil Health
Development of CPE/ssDNA-Based Electrochemical Sensor for the Detection of Leucine to Assess Soil Health Open
For the first time, the interaction between the amino acid leucine (Leu) and thermally denatured single-stranded (ss) DNA has been demonstrated by applying voltammetry. As a result of interaction, the characteristic peak of ssDNA, due to t…
View article: Redox-Active Quinazolinone Thioamide Ag(I) Complexes with Potent Antibacterial Activity: Mechanistic Insights and Hydrogel-Enhanced Efficacy
Redox-Active Quinazolinone Thioamide Ag(I) Complexes with Potent Antibacterial Activity: Mechanistic Insights and Hydrogel-Enhanced Efficacy Open
The antibacterial properties of Ag(I) coordination compounds are well documented; however, their effectiveness is highly dependent on the choice of appropriate ligands, and it is frequently hindered by their low water solubility and limite…
View article: Development of CPE/ssDNA-Based Electrochemical Sensor for the Detection of Leucine to Assess Soil Health
Development of CPE/ssDNA-Based Electrochemical Sensor for the Detection of Leucine to Assess Soil Health Open
For the first time, an interaction between the amino acid leucine (Leu) and thermally denatured single stranded (ss) DNA has been demonstrated by applying voltammetry. As a result of interaction, the characteristic peak of ssDNA, due to th…
View article: Detection of Leucine Based upon the Development of a CPE/ssDNA Biosensor
Detection of Leucine Based upon the Development of a CPE/ssDNA Biosensor Open
Leucine (Leu) is an amino acid which is considered to be an important compound in health matters and lately is recognized as an indicator of carbon storage. For the first time, an interaction between the amino acid leucine and thermally de…
View article: Carbon Nanotube-Mediated Delivery of PTEN Variants: In Vitro Antitumor Activity in Breast Cancer Cells
Carbon Nanotube-Mediated Delivery of PTEN Variants: In Vitro Antitumor Activity in Breast Cancer Cells Open
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a crucial tumor suppressor protein with frequent mutations and alterations. Although protein therapeutics are already integral to numerous medical fields, their potential …
View article: Synthesis of Novel Nanocomposite Materials with Enhanced Antimicrobial Activity based on Poly(Ethylene Glycol Methacrylate)s with Ag, TiO2 or ZnO Nanoparticles
Synthesis of Novel Nanocomposite Materials with Enhanced Antimicrobial Activity based on Poly(Ethylene Glycol Methacrylate)s with Ag, TiO2 or ZnO Nanoparticles Open
The aim of this investigation was to prepare novel hybrid materials with enhanced antimicrobial properties to be used in food preservation and packaging applications. Therefore, nanocomposite materials were synthesized based on two stimuli…
View article: CCDC 2246352: Experimental Crystal Structure Determination
CCDC 2246352: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2246350: Experimental Crystal Structure Determination
CCDC 2246350: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2246351: Experimental Crystal Structure Determination
CCDC 2246351: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Functional polysaccharide-coated SPIONs for <i>in vitro</i> mRNA delivery in breast cancer cells
Functional polysaccharide-coated SPIONs for <i>in vitro</i> mRNA delivery in breast cancer cells Open
Modified polysaccharide coated SPIONs for effective gene delivery. Comparison of covalent vs. ionic binding of a nucleic acid onto the SPIONs for mRNA-delivery – synthesis and physicochemical and biological assessment of functionalized SPI…
View article: In Vitro Chondrogenesis Induction by Short Peptides of the Carboxy-Terminal Domain of Transforming Growth Factor β1
In Vitro Chondrogenesis Induction by Short Peptides of the Carboxy-Terminal Domain of Transforming Growth Factor β1 Open
Τransforming growth factor β1 (TGF-β1) comprises a key regulator protein in many cellular processes, including in vivo chondrogenesis. The treatment of human dental pulp stem cells, separately, with Leu83-Ser112 (C-terminal domain of TGF-β…
View article: Study of Biological Behavior and Antimicrobial Properties of Cerium Oxide Nanoparticles
Study of Biological Behavior and Antimicrobial Properties of Cerium Oxide Nanoparticles Open
(1) Background: An element that has gained much attention in industrial and biomedical fields is Cerium (Ce). CeO2 nanoparticles have been proven to be promising regarding their different biomedical applications for the control of infectio…
View article: Ιn vitro RNA delivery in breast cancer cells using polysaccharide functionalized SPIONs
Ιn vitro RNA delivery in breast cancer cells using polysaccharide functionalized SPIONs Open
RNA-based pharmaceuticals have recently emerged as a novel platform for the prevention and treatment of numerous pathological conditions, including cancer, diabetes, and heart disease among others, because they demonstrate great potential …
View article: Fabrication of a Smart Fibrous Biomaterial That Harbors an Active TGF-β1 Peptide: A Promising Approach for Cartilage Regeneration
Fabrication of a Smart Fibrous Biomaterial That Harbors an Active TGF-β1 Peptide: A Promising Approach for Cartilage Regeneration Open
The regeneration of articular cartilage remains a serious problem in various pathological conditions such as osteoarthritis, due to the tissue’s low self-healing capacity. The latest therapeutic approaches focus on the construction of biom…
View article: Inhibition of PERK Kinase, an Orchestrator of the Unfolded Protein Response (UPR), Significantly Reduces Apoptosis and Inflammation of Lung Epithelial Cells Triggered by SARS-CoV-2 ORF3a Protein
Inhibition of PERK Kinase, an Orchestrator of the Unfolded Protein Response (UPR), Significantly Reduces Apoptosis and Inflammation of Lung Epithelial Cells Triggered by SARS-CoV-2 ORF3a Protein Open
SARS-CoV-2 ORF3a accessory protein was found to be involved in virus release, immunomodulation and exhibited a pro-apoptotic character. In order to unravel a potential ORF3a-induced apoptotic and inflammatory death mechanism, lung epitheli…
View article: Therapeutic and Diagnostic Potential of Exosomes as Drug Delivery Systems in Brain Cancer
Therapeutic and Diagnostic Potential of Exosomes as Drug Delivery Systems in Brain Cancer Open
Cancer is designated as one of the principal causes of mortality universally. Among different types of cancer, brain cancer remains the most challenging one due to its aggressiveness, the ineffective permeation ability of drugs through the…
View article: A Novel Drastic Peptide Genetically Adapted to Biomimetic Scaffolds “Delivers” Osteogenic Signals to Human Mesenchymal Stem Cells
A Novel Drastic Peptide Genetically Adapted to Biomimetic Scaffolds “Delivers” Osteogenic Signals to Human Mesenchymal Stem Cells Open
This work describes the design, preparation, and deep investigation of “intelligent nanobiomaterials” that fulfill the safety rules and aim to serve as “signal deliverers” for osteogenesis, harboring a specific peptide that promotes and en…
View article: ssDNA-Modified Gold Nanoparticles as a Tool to Detect miRNA Biomarkers in Osteoarthritis
ssDNA-Modified Gold Nanoparticles as a Tool to Detect miRNA Biomarkers in Osteoarthritis Open
Recently, miRNAs have been established as promising, specific biomarkers for the diagnosis of many diseases, including osteoarthritis. Herein, we report a ssDNA-based detection method for miRNAs implicated in osteoarthritis, specifically, …
View article: Inhibition of Cancer Cell Proliferation and Bacterial Growth by Silver(I) Complexes Bearing a CH3-Substituted Thiadiazole-Based Thioamide
Inhibition of Cancer Cell Proliferation and Bacterial Growth by Silver(I) Complexes Bearing a CH3-Substituted Thiadiazole-Based Thioamide Open
Ag(I) coordination compounds have recently attracted much attention as antiproliferative and antibacterial agents against a wide range of cancer cell lines and pathogens. The bioactivity potential of these complexes depends on their struct…
View article: CCDC 2152740: Experimental Crystal Structure Determination
CCDC 2152740: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2152741: Experimental Crystal Structure Determination
CCDC 2152741: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2152742: Experimental Crystal Structure Determination
CCDC 2152742: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2152743: Experimental Crystal Structure Determination
CCDC 2152743: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2097446: Experimental Crystal Structure Determination
CCDC 2097446: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2097447: Experimental Crystal Structure Determination
CCDC 2097447: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2097450: Experimental Crystal Structure Determination
CCDC 2097450: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …