Riham El Sayed
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View article: Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis
Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis Open
Follicular dendritic cells (FDCs) fundamentally contribute to the formation of synovial ectopic lymphoid-like structures in rheumatoid arthritis (RA) which is associated with poor clinical prognosis. Despite this critical role, regulation …
View article: <p>MicroRNAs and Risk Factors for Diabetic Nephropathy in Egyptian Children and Adolescents with Type 1 Diabetes</p>
MicroRNAs and Risk Factors for Diabetic Nephropathy in Egyptian Children and Adolescents with Type 1 Diabetes Open
miRNA-377, miRNA-93, miRNA-216a, and miRNA-21 may be implicated in the pathogenesis of DN, while miRNA-25 may have a reno-protective role. More studies are needed to document the value of these miRNAs as diagnostic biomarkers as well as th…
View article: Role of dendritic cell‐mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw
Role of dendritic cell‐mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw Open
Dendritic cells are an important link between innate and adaptive immune response. The role of dendritic cells in bone homeostasis, however, is not understood. Osteoporosis medications that inhibit osteoclasts have been associated with ost…
View article: Etiology of hyperglycemia in critically ill children and the impact of organ dysfunction
Etiology of hyperglycemia in critically ill children and the impact of organ dysfunction Open
β-Cell dysfunction appeared to be prevalent in our cohort and was associated with multi-organ dysfunction.
View article: Etiology of hyperglycemia in critically ill children and the impact of organ dysfunction
Etiology of hyperglycemia in critically ill children and the impact of organ dysfunction Open
Objective: This study aimed to study the incidence of stress hyperglycemia in critically ill children and to investigate the etiological basis of the hyperglycemia based on homeostasis model assessment. Methods: This was a prospective coho…
View article: CD209-336A/G promotor polymorphism and its clinical associations in sickle cell disease Egyptian Pediatric patients
CD209-336A/G promotor polymorphism and its clinical associations in sickle cell disease Egyptian Pediatric patients Open
Objectives: To detect the frequency of CD209 A>G polymorphism in sickle cell disease (SCD) Egyptian patients and to evaluate the use of CD209 A>G polymorphism as a genetic predictor of SCD clinical heterogeneity. Methods: A total of 100 Eg…
View article: ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses
ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses Open
The proper regulation of ICOS and ICOS ligand (ICOSL) has been shown to be essential for maintaining proper immune homeostasis. Loss of either protein results in defective humoral immunity, and overexpression of ICOS results in aberrant Ab…
View article: Case Report Whole-exome analysis of a child with polycystic kidney disease and ventriculomegaly
Case Report Whole-exome analysis of a child with polycystic kidney disease and ventriculomegaly Open
Autosomal recessive polycystic kidney disease (ARPKD) is an inherited ciliopathy leading to progressive kidney and liver disease. Biallelic mutations in the PKHD1 gene underlie this condition. We describe a child with bilaterally enlarged …