Rik A. Brooimans
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View article: Reduced numbers of naïve CD4 + T cells and an altered CD4/CD8 balance in depressed common variable immune deficiency (CVID) patients. Is thymosin-α1 a possible treatment?
Reduced numbers of naïve CD4 + T cells and an altered CD4/CD8 balance in depressed common variable immune deficiency (CVID) patients. Is thymosin-α1 a possible treatment? Open
In the 1990's the macrophage-T-cell-theory of depression was posed stating that low grade inflammation and an abnormal T cell system destabilize the development and function of the emotional brain in such a way, that individuals become ult…
View article: Three patients with defects in interferon gamma receptor signaling: A challenging diagnosis
Three patients with defects in interferon gamma receptor signaling: A challenging diagnosis Open
Three patients with defects in interferon gamma receptor signaling: A challenging diagnosisTo the Editor, Mendelian susceptibility to mycobacterial disease (MSMD) is a rare inherited disorder characterized by infections with weakly virulen…
View article: Author response for "Three patients with defects in interferon gamma receptor signaling: A challenging diagnosis"
Author response for "Three patients with defects in interferon gamma receptor signaling: A challenging diagnosis" Open
View article: Three patients with defects in interferon gamma receptor signaling: a challenging diagnosis
Three patients with defects in interferon gamma receptor signaling: a challenging diagnosis Open
Background: Defects in IFN–gamma receptor (IFN-γR) signaling via STAT1 leads to susceptibility to infection by otherwise weak pathogenic mycobacteria, resulting in mendelian susceptibility to mycobacterial disease. We identified three pati…
View article: Three Patients With Disseminated Mycobacterial Infections Due to Severe Defects in Interferon Gamma Receptor Signaling: A Challenging Diagnosis
Three Patients With Disseminated Mycobacterial Infections Due to Severe Defects in Interferon Gamma Receptor Signaling: A Challenging Diagnosis Open
IFN–gamma receptor (IFNGR) signaling via STAT1 is crucial in the defense against intracellular pathogens. Defects in this pathway enhance the susceptibility to infection by otherwise weak pathogenic mycobacteria, resulting in a primary imm…
View article: No Evidence for Circulating Retina Specific Autoreactive T-cells in Latent Tuberculosis-associated Uveitis and Sarcoid Uveitis
No Evidence for Circulating Retina Specific Autoreactive T-cells in Latent Tuberculosis-associated Uveitis and Sarcoid Uveitis Open
Purpose: To detect circulating retina-specific autoreactive CD4+ T-cells and antiretinal antibodies (ARA) in latent tuberculosis (TB)-associated uveitis or sarcoid uveitis patients.Methods: The presence of crude re…
View article: Immunophenotypic measurable residual disease (MRD) in acute myeloid leukemia: Is multicentric MRD assessment feasible?
Immunophenotypic measurable residual disease (MRD) in acute myeloid leukemia: Is multicentric MRD assessment feasible? Open
View article: Table of contents
Table of contents Open
View article: Fifteen years of external quality assessment in leukemia/lymphoma immunophenotyping in <scp>T</scp>he <scp>N</scp>etherlands and <scp>B</scp>elgium: A way forward
Fifteen years of external quality assessment in leukemia/lymphoma immunophenotyping in <span>T</span>he <span>N</span>etherlands and <span>B</span>elgium: A way forward Open
In 1985, external quality assurance was initiated in the Netherlands to reduce the between‐laboratory variability of leukemia/lymphoma immunophenotyping and to improve diagnostic conclusions. This program consisted of regular distributions…