Rik P. van Rosmalen
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View article: Computer-assisted multilevel optimization of malonyl-CoA availability in Pseudomonas putida
Computer-assisted multilevel optimization of malonyl-CoA availability in Pseudomonas putida Open
Malonyl-CoA is the major precursor for the biosynthesis of diverse industrially valuable products such as fatty acids/alcohols, flavonoids, and polyketides. However, its intracellular availability is limited in most microbial hosts, hamper…
View article: Computer assisted multi-level optimization of malonyl-CoA availability in<i>Pseudomonas putida</i>
Computer assisted multi-level optimization of malonyl-CoA availability in<i>Pseudomonas putida</i> Open
Malonyl-CoA is the major precursor for the biosynthesis of diverse industrially valuable products such as fatty acids/alcohols, flavonoids, and polyketides. However, its intracellular availability is limited in most microbial hosts, hamper…
View article: CFSA: Comparative flux sampling analysis as a guide for strain design
CFSA: Comparative flux sampling analysis as a guide for strain design Open
Genome-scale metabolic models of microbial metabolism have extensively been used to guide the design of microbial cell factories, still, many of the available strain design algorithms often fail to produce a reduced list of targets for imp…
View article: Model-guided metabolic engineering of curcuminoid Production in<i>Pseudomonas putida</i>
Model-guided metabolic engineering of curcuminoid Production in<i>Pseudomonas putida</i> Open
Production of value-added, plant-derived compounds in microbes increasingly attracts commercially interest in food and pharmaceutical industries. However, plant metabolic pathways are complex, require a robust balance of enzymes, cofactors…
View article: CFSA: Comparative Flux Sampling Analysis as a Guide for Strain Design
CFSA: Comparative Flux Sampling Analysis as a Guide for Strain Design Open
Genome-scale metabolic models of microbial metabolism have extensively been used to guide the design of microbial cell factories, still, many of the available strain design algorithms often fail to produce a reduced list of targets for imp…
View article: Questions, data and models underpinning metabolic engineering
Questions, data and models underpinning metabolic engineering Open
Model-driven design has shown great promise for shortening the development time of cell factories by complementing and guiding metabolic engineering efforts. Still, implementation of the prized cycle of model predictions followed by experi…
View article: Model reduction of genome-scale metabolic models as a basis for targeted kinetic models
Model reduction of genome-scale metabolic models as a basis for targeted kinetic models Open
View article: Live Cell Imaging of Male Meiosis in Arabidopsis by a Landmark-based System
Live Cell Imaging of Male Meiosis in Arabidopsis by a Landmark-based System Open
Live cell imaging has tremendously promoted our understanding of cellular and subcellular processes such as cell division. Here, we present a step-by-step protocol for a robust and easy-to-use live cell imaging approach to study male meios…
View article: Live cell imaging of meiosis in Arabidopsis thaliana
Live cell imaging of meiosis in Arabidopsis thaliana Open
To follow the dynamics of meiosis in the model plant Arabidopsis, we have established a live cell imaging setup to observe male meiocytes. Our method is based on the concomitant visualization of microtubules (MTs) and a meiotic cohesin sub…
View article: Author response: Live cell imaging of meiosis in Arabidopsis thaliana
Author response: Live cell imaging of meiosis in Arabidopsis thaliana Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract To follow the dynamics of mei…
View article: Live cell imaging of meiosis in <i>Arabidopsis thaliana</i> - a landmark system
Live cell imaging of meiosis in <i>Arabidopsis thaliana</i> - a landmark system Open
Meiosis is essential for sexual reproduction and key to the generation of genetic diversity. To reveal the robustness of meiocyte differentiation and progression through meiosis, we have here established a live cell imaging setup to follow…
View article: DMPy: a Python package for automated mathematical model construction of large-scale metabolic systems
DMPy: a Python package for automated mathematical model construction of large-scale metabolic systems Open
View article: Additional file 2 of DMPy: a Python package for automated mathematical model construction of large-scale metabolic systems
Additional file 2 of DMPy: a Python package for automated mathematical model construction of large-scale metabolic systems Open
Parameter values. Reaction rates that were obtained by our automated database search for different metabolic systems. (XLSX 510 kb)