Rika Noji
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View article: Characterization of a novel comprehensive genomic profiling test with better detection of heterozygous deletions and RNA-based gene fusion analysis
Characterization of a novel comprehensive genomic profiling test with better detection of heterozygous deletions and RNA-based gene fusion analysis Open
Cancer genomic profiling has revolutionized cancer research and clinical practice by facilitating personalized medicine approaches. Next-generation sequencing technologies have played a pivotal role in expanding the possibilities of cancer…
View article: Dynamic Changes in Circulating Tumor DNA During Immunotherapy for Head and Neck Cancer: SHIZUKU-HN Study
Dynamic Changes in Circulating Tumor DNA During Immunotherapy for Head and Neck Cancer: SHIZUKU-HN Study Open
Immune checkpoint inhibitors (ICIs) are effective in treating recurrent/metastatic head and neck squamous cell carcinoma (HNSCC), but only 20% of patients achieve durable responses. This study evaluated circulating tumor DNA (ctDNA) as a r…
View article: Chemotherapy and COVID-19 Vaccination in Patients With Gastrointestinal Cancer
Chemotherapy and COVID-19 Vaccination in Patients With Gastrointestinal Cancer Open
Systemic chemotherapy in patients with GI cancer does not have a markedly negative effect on COVID-19 vaccination, resulting in manageable vaccine-related AEs, and minimizing the need for treatment schedule changes.
View article: The Efficacy of Immunotherapy and Clinical Utility of Comprehensive Genomic Profiling in Adenoid Cystic Carcinoma of Head and Neck
The Efficacy of Immunotherapy and Clinical Utility of Comprehensive Genomic Profiling in Adenoid Cystic Carcinoma of Head and Neck Open
Background and Objectives: Adenoid cystic carcinoma (ACC) of the head and neck is generally slow-growing but has a high potential for local recurrence and metastasis to distant organs. There is currently no standard pharmacological treatme…
View article: A rare case of solitary intraoral superficial angiomyxoma arising in the soft palate
A rare case of solitary intraoral superficial angiomyxoma arising in the soft palate Open
Superficial angiomyxomas are myxoid mesenchymal tumors, and intraoral superficial angiomyxoma is extremely rare. This paper reports a novel case of a 41-year-old Japanese male patient with a 32 × 22 mm superficial angiomyxoma in the right …
View article: Comprehensive Genomic Profiling Reveals Clinical Associations in Response to Immune Therapy in Head and Neck Cancer
Comprehensive Genomic Profiling Reveals Clinical Associations in Response to Immune Therapy in Head and Neck Cancer Open
Comprehensive genomic profiling (CGP) provides information regarding cancer-related genetic aberrations. However, its clinical utility in recurrent/metastatic head and neck cancer (R/M HNC) remains unknown. Additionally, predictive biomark…
View article: The clinical utility of comprehensive genomic profiling for recurrent / metastatic head and neck cancer
The clinical utility of comprehensive genomic profiling for recurrent / metastatic head and neck cancer Open
頭頸部癌患者14例18件に対しFoundationOne CDxなどのがん遺伝子パネル検査を使用し,組織検体15件(83.3%),血液検体3件(16.6%)における遺伝子変異の解析を行った。原発部位別では,舌癌が6例(42.8%)と最多で,検出された遺伝子変異としてはTP53,TERT promoter,CDKN2Aなどであり,全ゲノム解析を用いた既報と矛盾しない結果となった。14例のうち,治療候補があった症例は11 例(78.6%)であったが,実際に遺伝子パネル検査に基づ…