Riki Koike
YOU?
Author Swipe
View article: Virtual reality navigation for the early detection of Alzheimer’s disease
Virtual reality navigation for the early detection of Alzheimer’s disease Open
Objective The development of non-invasive clinical diagnostics is paramount for the early detection of Alzheimer’s disease (AD). Neurofibrillary tangles in AD originate from the entorhinal cortex, a cortical memory area that mediates navig…
View article: Path Integration Detects Prodromal Alzheimer’s Disease and Predicts Cognitive Decline
Path Integration Detects Prodromal Alzheimer’s Disease and Predicts Cognitive Decline Open
Background: The entorhinal cortex is the very earliest involvement of Alzheimer’s disease (AD). Grid cells in the medial entorhinal cortex form part of the spatial navigation system. Objective: We aimed to determine whether path integratio…
View article: A novel monoclonal antibody generated by immunization with granular tau oligomers binds to tau aggregates at 423-430 amino acid sequence
A novel monoclonal antibody generated by immunization with granular tau oligomers binds to tau aggregates at 423-430 amino acid sequence Open
View article: Early detection of Alzheimer’s disease pathophysiology using 3D virtual reality navigation: a correlational study with genetic and plasma biomarkers
Early detection of Alzheimer’s disease pathophysiology using 3D virtual reality navigation: a correlational study with genetic and plasma biomarkers Open
BACKGROUND We investigated the association between path-integration (PI) errors related to entorhinal cortex function detectable using a 3D virtual reality (VR) navigation system and various biomarkers to explore its potential as an early …
View article: Path integration deficits are associated with phosphorylated tau accumulation in the entorhinal cortex
Path integration deficits are associated with phosphorylated tau accumulation in the entorhinal cortex Open
Alzheimer’s disease is a devastating disease that is accompanied by dementia, and its incidence increases with age. However, no interventions have exhibited clear therapeutic effects. We aimed to develop and characterize behavioural tasks …
View article: Path integration deficits predict phosphorylated tau accumulation in the entorhinal cortex: Assessment of Braak stage I,II using 3D Virtual reality goggles
Path integration deficits predict phosphorylated tau accumulation in the entorhinal cortex: Assessment of Braak stage I,II using 3D Virtual reality goggles Open
Background We aimed to develop behavioral tasks that can identify early signs of Alzheimer’s disease (AD) in order to facilitate the development of preventative and therapeutic interventions. Method To do this, we created a 3D virtual real…
View article: Intracellular Tau Fragment Droplets Serve as Seeds for Tau Fibrils
Intracellular Tau Fragment Droplets Serve as Seeds for Tau Fibrils Open
Summary Intracellular tau aggregation requires a local protein concentration increase, referred to as "droplets". However, the cellular mechanism for droplet formation is poorly understood. Here, we expressed OptoTau, a P301L mutant tau fu…
View article: Intracellular Tau Fragment Droplets Serve as Seeds for Tau Fibrils
Intracellular Tau Fragment Droplets Serve as Seeds for Tau Fibrils Open
View article: Path integration deficits with phosphorylated tau accumulation in the entorhinal cortex in mice and humans
Path integration deficits with phosphorylated tau accumulation in the entorhinal cortex in mice and humans Open
Background Alzheimer's disease (AD) is a devastating disease that is accompanied by dementia, and its incidence increases with age. However, no interventions have exhibited clear therapeutic effects. We aimed to develop and characterize be…
View article: Can the entorhinal cortex help distinguish healthy aging brains from pathological aging brains?
Can the entorhinal cortex help distinguish healthy aging brains from pathological aging brains? Open
View article: Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus)
Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus) Open
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) as senile plaques and cerebral amyloid angiopathy, and hyperphosphorylated tau (hp-tau) as neurofibrillary tangles in the brain. The AD-related pathology has b…
View article: Memory formation in old age requires GSK-3β
Memory formation in old age requires GSK-3β Open
Glycogen synthase kinase 3β (GSK-3β) is a therapeutic target for various age-related neurodegenerative diseases. It is linked to the two main pathological features of Alzheimer's disease (AD), tau and amyloid β (Aβ); GSK-3β is a major cand…