Ryuji Kato
YOU?
Author Swipe
View article: Duckweed (Wolffia globosa) improves intestinal epithelial barrier function induced by gut microbial metabolites in vitro
Duckweed (Wolffia globosa) improves intestinal epithelial barrier function induced by gut microbial metabolites in vitro Open
View article: Kinetic and thermodynamic evaluation of antioxidant reactions: factors influencing the radical scavenging properties of phenolic compounds in foods
Kinetic and thermodynamic evaluation of antioxidant reactions: factors influencing the radical scavenging properties of phenolic compounds in foods Open
Background Antioxidants can prevent oxidative stress‐induced aging and diseases, and many antioxidant screening tests have been conducted in the pharmaceutical and food industries. However, the potencies of antioxidants calculated using st…
View article: Label-free morphology-based phenotypic analysis of spinal and bulbar muscular atrophy muscle cell models
Label-free morphology-based phenotypic analysis of spinal and bulbar muscular atrophy muscle cell models Open
Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disorder caused by CAG trinucleotide expansion in the androgen receptor (AR) gene. To improve the quality of in vitro cell-based assays for the evaluation of potential drug candi…
View article: Label-free morphology-based phenotypic analysis of spinal and bulbar muscular atrophy muscle cell models
Label-free morphology-based phenotypic analysis of spinal and bulbar muscular atrophy muscle cell models Open
Background Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disorder caused by a CAG trinucleotide expansion in the androgen receptor (AR) gene. The pathogenesis of SBMA is not fully understood and there are less effective trea…
View article: Editorial: Artificial intelligence in predicting, determining and controlling cell phenotype or tissue function in inflammatory diseases
Editorial: Artificial intelligence in predicting, determining and controlling cell phenotype or tissue function in inflammatory diseases Open
Editorial: Artificial intelligence in predicting, determining and controlling cell phenotype or tissue function in inflammatory diseases
View article: Tissue Distribution of Cisplatin by Intra-arterial Infusion Route in Comparison to Systemic Route: Implication to Therapy for Node-positive Bladder Cancer
Tissue Distribution of Cisplatin by Intra-arterial Infusion Route in Comparison to Systemic Route: Implication to Therapy for Node-positive Bladder Cancer Open
High cisplatin accumulation in the lymphatic tissue and bladder by IA administration may have a potential role for treating patients with node-positive bladder cancer.
View article: Difference in the Frequency and Mechanism of Non-Steroidal Anti-Androgen-Induced Liver Injury: Reactive Metabolites of Flutamide and Bicalutamide Activate Inflammasomes
Difference in the Frequency and Mechanism of Non-Steroidal Anti-Androgen-Induced Liver Injury: Reactive Metabolites of Flutamide and Bicalutamide Activate Inflammasomes Open
View article: Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis
Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis Open
Although clozapine is a highly efficacious schizophrenia treatment, it is under-prescribed due to the risk of idiosyncratic drug-induced agranulocytosis (IDIAG). Clinical data indicate that most patients starting clozapine experience a tra…
View article: Rivaroxaban Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Hypertension
Rivaroxaban Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Hypertension Open
Pulmonary arterial hypertension (PAH) is a progressive condition that frequently results in right ventricular (RV) remodeling. The objectives of this study are to investigate effects of rivaroxaban on RV remodeling in a rat model of PAH, c…
View article: Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction
Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction Open
The epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have been approved for non-small cell lung cancer. Although EGFR TKIs are less toxic than traditional cytotoxic therapies, they cause many severe idiosyncratic dru…
View article: The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions
The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions Open
View article: Effective screening for hypolipidemic bile acid - binding peptides by hierarchical clustering - based catalog array
Effective screening for hypolipidemic bile acid - binding peptides by hierarchical clustering - based catalog array Open
Peptide arrays, which are high-throughput combinatorial screening platforms, have a limited capacity for exploring vast amino acid sequence combinations.To mitigate such limitations, we propose the concept of "catalog array," comprised of …
View article: P2501Rivaroxaban combined with spironolactone attenuates cardiovascular remodeling due to hypoxia in pulmonary arterial hypertension
P2501Rivaroxaban combined with spironolactone attenuates cardiovascular remodeling due to hypoxia in pulmonary arterial hypertension Open
View article: Factor Xa inhibition by rivaroxaban attenuates cardiac remodeling due to intermittent hypoxia
Factor Xa inhibition by rivaroxaban attenuates cardiac remodeling due to intermittent hypoxia Open
Patients with obstructive sleep apnea (OSA) have a high prevalence of atrial fibrillation (AF). Rivaroxaban, a coagulation factor Xa inhibitor, has recently been reported to show pleiotropic effects. This study investigated the influence o…
View article: A Panel of MicroRNA Signature as a Tool for Predicting Survival of Patients with Urothelial Carcinoma of the Bladder
A Panel of MicroRNA Signature as a Tool for Predicting Survival of Patients with Urothelial Carcinoma of the Bladder Open
Introduction and Objectives. MicroRNA (miRNA) expression is altered in urologic malignancies, including urothelial carcinoma of the bladder (UCB). Individual miRNAs have been shown to modulate multiple signaling pathways that contribute to…
View article: Rivaroxaban attenuates vascular remodeling of heart and lung in PAH through suppression of ERK1/2 and NF-kB phosphorylation
Rivaroxaban attenuates vascular remodeling of heart and lung in PAH through suppression of ERK1/2 and NF-kB phosphorylation Open
Objective: We have reported that capillary degeneration in heart, observed in the early stage of pulmonary arterial hypertension (PAH), accelerates right ventricular (RV) remodeling in rats treated with Sugen5416 and chronic hypoxia. Recen…
View article: The 1st step initiation essential for allergen‐specific IgE antibody production upon the 2nd step: Induction of non‐specific IgE<sup>+</sup> small B cells containing secondly‐sensitized allergen‐specific ones in mice firstly‐sensitized with an allergen
The 1st step initiation essential for allergen‐specific IgE antibody production upon the 2nd step: Induction of non‐specific IgE<sup>+</sup> small B cells containing secondly‐sensitized allergen‐specific ones in mice firstly‐sensitized with an allergen Open
There was a significant amount of non‐specific, but not of allergen (e.g., papain, mite feces and four kinds of pollen)‐specific, IgE antibodies (Abs) in the sera of normal mice. An i.n. injection of each allergen without adjuvant into mic…
View article: Editor’s Highlight: An Impaired Immune Tolerance Animal Model Distinguishes the Potential of Troglitazone/Pioglitazone and Tolcapone/Entacapone to Cause IDILI
Editor’s Highlight: An Impaired Immune Tolerance Animal Model Distinguishes the Potential of Troglitazone/Pioglitazone and Tolcapone/Entacapone to Cause IDILI Open
We have developed an animal model of amodiaquine-induced liver injury that has characteristics very similar to idiosyncratic drug-induced liver injury (IDILI) in humans by impairing immune tolerance using a PD1-/- mouse and cotreatment wit…
View article: P5147Direct factor Xa inhibition prevents cardiac remodeling induced by intermittent hypoxia through PAR-1/2 dual signaling pathway
P5147Direct factor Xa inhibition prevents cardiac remodeling induced by intermittent hypoxia through PAR-1/2 dual signaling pathway Open
Background: Giant-cell myocarditis (GCM) is a rare aetiology of myocarditis.To date, clinical presentation, treatment and outcome have mainly been reported in case reports and small case series.In addition, clinical course of fulminant for…
View article: Completion Report of the Overseas Training Program Awarded by Japanese Society of Clinical Pharmacology and Therapeutics in 2015
Completion Report of the Overseas Training Program Awarded by Japanese Society of Clinical Pharmacology and Therapeutics in 2015 Open
View article: A Novel Analytical Method of Cisplatin Using the HPLC with a Naphthylethyl Group Bonded with Silica Gel (πNAP) Column
A Novel Analytical Method of Cisplatin Using the HPLC with a Naphthylethyl Group Bonded with Silica Gel (πNAP) Column Open
Cisplatin is the most widely used anticancer drug in the world. Mono-chloro and none-chloro complexes of cisplatin may be believed to be the activated compounds. The separation of these compounds using octa decyl silyl column or aminopropy…
View article: Mechanisms of Increased Survival in Lipopolysaccharide-Treated Mice With a Single Subcutaneous Capsaicin Challenge
Mechanisms of Increased Survival in Lipopolysaccharide-Treated Mice With a Single Subcutaneous Capsaicin Challenge Open
Background: Capsaicin, a pungent compound present in capsicum fruits, has various biological activities such as stimulation of transient receptor potential vanilloid-1 (TRPV-1) and/or inhibition of tumor necrosis factor-alpha (TNF-α). This…