Rima Jubran
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View article: The use of aqueous humor cfDNA for low-pass whole genome sequencing as a clinical test to identify intraocular retinoblastoma recurrence
The use of aqueous humor cfDNA for low-pass whole genome sequencing as a clinical test to identify intraocular retinoblastoma recurrence Open
Objective: Patients with retinoblastoma (RB) require serial examinations under anesthesia (EUA) to assess for response to treatment and disease recurrence. Monitoring for disease recurrence is complicated in patients with loss of fundoscop…
View article: A multi‐institutional feasibility study of intra‐arterial chemotherapy in children with retinoblastoma. A Children's Oncology Group study (COG ARET12P1)
A multi‐institutional feasibility study of intra‐arterial chemotherapy in children with retinoblastoma. A Children's Oncology Group study (COG ARET12P1) Open
Background Intra‐arterial chemotherapy (IA) as a treatment to salvage the eye with advanced retinoblastoma is increasingly utilized based on successes reported by institutions around the world mainly through retrospective studies. Objectiv…
View article: Supplemental Figure 4 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma
Supplemental Figure 4 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Open
Supplemental Figure 4, online only: Initial Copy Number Alteration (CNA) profile from eyes that were successfully salvaged with treatment
View article: Supplementary Table 1 from Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival
Supplementary Table 1 from Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival Open
Supplementary Table 1. Retinoblastoma (RB) patient demographics, clinical outcomes, and RB somatic copy number alterations (SCNAs) at a large RB treatment center.
View article: Supplemental Figure 2 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma
Supplemental Figure 2 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Open
Supplemental Figure 2, online only: Hierarchical clustering matrix based on the genomic instability of the Copy Number Alteration (CNA) profiles of all the AH samples included in this analysis. Samples are listed by Case number_# based on …
View article: Data from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma
Data from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Open
Tumor-derived cell-free DNA (cfDNA) has biomarker potential; therefore, this study aimed to identify cfDNA in the aqueous humor (AH) of retinoblastoma eyes and correlate somatic chromosomal copy-number alterations (SCNA) with clinical outc…
View article: Supplemental Figure 1 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma
Supplemental Figure 1 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Open
Supplemental Figure 1, online only: a positive correlation was seen between the age at diagnosis and genomic instability which is defined as the overall size of the copy number variation found in the initial AH samples (p=<0.0001, R2=0.658…
View article: Supplemental Figure 4 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma
Supplemental Figure 4 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Open
Supplemental Figure 4, online only: Initial Copy Number Alteration (CNA) profile from eyes that were successfully salvaged with treatment
View article: Data from Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival
Data from Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival Open
Aqueous humor contains tumor-derived cell-free DNA (cfDNA) and can serve as a liquid biopsy for retinoblastoma. We previously associated somatic copy-number alteration (SCNA) 6p gain with a 10-fold increased risk of enucleation. Here we pr…
View article: Data from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma
Data from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Open
Tumor-derived cell-free DNA (cfDNA) has biomarker potential; therefore, this study aimed to identify cfDNA in the aqueous humor (AH) of retinoblastoma eyes and correlate somatic chromosomal copy-number alterations (SCNA) with clinical outc…
View article: Supplementary Table 1 from Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival
Supplementary Table 1 from Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival Open
Supplementary Table 1. Retinoblastoma (RB) patient demographics, clinical outcomes, and RB somatic copy number alterations (SCNAs) at a large RB treatment center.
View article: Supplemental Figure 1 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma
Supplemental Figure 1 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Open
Supplemental Figure 1, online only: a positive correlation was seen between the age at diagnosis and genomic instability which is defined as the overall size of the copy number variation found in the initial AH samples (p=<0.0001, R2=0.658…
View article: Supplemental Figure 5 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma
Supplemental Figure 5 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Open
Supplemental Figure 5, online only: Copy Number Alteration (CNA) profiles from Case 11, 21, and 25 demonstrating change in amplitude of the alterations in longitudinal AH samples taken over time. Case 11 showed a progressive gain of 6p and…
View article: Data from Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival
Data from Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival Open
Aqueous humor contains tumor-derived cell-free DNA (cfDNA) and can serve as a liquid biopsy for retinoblastoma. We previously associated somatic copy-number alteration (SCNA) 6p gain with a 10-fold increased risk of enucleation. Here we pr…
View article: Supplemental Figure 5 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma
Supplemental Figure 5 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Open
Supplemental Figure 5, online only: Copy Number Alteration (CNA) profiles from Case 11, 21, and 25 demonstrating change in amplitude of the alterations in longitudinal AH samples taken over time. Case 11 showed a progressive gain of 6p and…
View article: Supplemental Figure 3 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma
Supplemental Figure 3 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Open
Supplemental Figure 3, online only: Initial Copy Number Alteration (CNA) profile from eyes that required enucleation + indicates that in Case 11 the second AH sample (which had good alignment and demonstrates gain of 6p) is shown instead o…
View article: Supplemental Figure 2 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma
Supplemental Figure 2 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Open
Supplemental Figure 2, online only: Hierarchical clustering matrix based on the genomic instability of the Copy Number Alteration (CNA) profiles of all the AH samples included in this analysis. Samples are listed by Case number_# based on …
View article: Supplemental Figure 3 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma
Supplemental Figure 3 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Open
Supplemental Figure 3, online only: Initial Copy Number Alteration (CNA) profile from eyes that required enucleation + indicates that in Case 11 the second AH sample (which had good alignment and demonstrates gain of 6p) is shown instead o…
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View article: Intensive Multimodality Therapy for Extraocular Retinoblastoma: A Children's Oncology Group Trial (ARET0321)
Intensive Multimodality Therapy for Extraocular Retinoblastoma: A Children's Oncology Group Trial (ARET0321) Open
PURPOSE Metastatic retinoblastoma has a poor prognosis when treated with conventional chemotherapy and radiation therapy (RT). Intensified therapy may improve the outcome. METHODS A prospective, international trial enrolled patients with e…
View article: Metastatic Death Based on Presenting Features and Treatment for Advanced Intraocular Retinoblastoma
Metastatic Death Based on Presenting Features and Treatment for Advanced Intraocular Retinoblastoma Open
View article: High-risk Pathologic Features Based on Presenting Findings in Advanced Intraocular Retinoblastoma
High-risk Pathologic Features Based on Presenting Findings in Advanced Intraocular Retinoblastoma Open
View article: Retinoblastoma seeds: impact on American Joint Committee on Cancer clinical staging
Retinoblastoma seeds: impact on American Joint Committee on Cancer clinical staging Open
Aim To investigate whether the American Joint Committee on Cancer (AJCC) clinical category cT2b needs to be subclassified by the type and distribution of retinoblastoma (RB) seeding. Methods Multicentre, international registry-based data w…
View article: Inter-eye genomic heterogeneity in bilateral retinoblastoma via aqueous humor liquid biopsy
Inter-eye genomic heterogeneity in bilateral retinoblastoma via aqueous humor liquid biopsy Open
View article: Comprehensive somatic copy number analysis using the aqueous humor liquid biopsy for retinoblastoma
Comprehensive somatic copy number analysis using the aqueous humor liquid biopsy for retinoblastoma Open
View article: Establishing the Clinical Utility of ctDNA Analysis for Diagnosis, Prognosis, and Treatment Monitoring of Retinoblastoma: The Aqueous Humor Liquid Biopsy
Establishing the Clinical Utility of ctDNA Analysis for Diagnosis, Prognosis, and Treatment Monitoring of Retinoblastoma: The Aqueous Humor Liquid Biopsy Open
Because direct tumor biopsy is prohibited for retinoblastoma (RB), eye-specific molecular biomarkers are not used in clinical practice for RB. Recently, we demonstrated that the aqueous humor (AH) is a rich liquid biopsy source of cell-fre…
View article: Response criteria for intraocular retinoblastoma: RB‐RECIST
Response criteria for intraocular retinoblastoma: RB‐RECIST Open
Standardized guidelines for assessing tumor response to therapy are essential for designing and conducting clinical trials. The Response Evaluation Criteria In Solid Tumors (RECIST) provide radiological standards for assessment of solid tu…
View article: Extracellular vesicle-associated repetitive element DNAs as candidate osteosarcoma biomarkers
Extracellular vesicle-associated repetitive element DNAs as candidate osteosarcoma biomarkers Open
Osteosarcoma (OS) is the most common malignant bone tumor in children and young adults. Despite that high-risk factors have been identified, no test for early detection is available. This study aimed to identify circulating nucleic acid se…
View article: Cell-Free DNA Tumor Fraction in the Aqueous Humor Is Associated With Therapeutic Response in Retinoblastoma Patients
Cell-Free DNA Tumor Fraction in the Aqueous Humor Is Associated With Therapeutic Response in Retinoblastoma Patients Open
Longitudinal evaluation of AH cfDNA may provide an objective, quantitative way to monitor therapeutic response and disease burden in RB patients.
View article: Simultaneous identification of clinically relevant <i>RB1</i> mutations and copy number alterations in aqueous humor of retinoblastoma eyes
Simultaneous identification of clinically relevant <i>RB1</i> mutations and copy number alterations in aqueous humor of retinoblastoma eyes Open
AH liquid biopsy is a minimally invasive, in vivo alternative to tissue analysis for the simultaneous identification of RB1 variants and SCNAs in RB eyes.